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7635557 |
Enzymatic diagnostic test for SARS and other viral diseases
The present invention is directed towards methods, compositions and kits for testing for a virus in a sample. The methods determine the presence of a viral enzyme by contacting the sample with a...
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7632635 |
Method for measuring resistance of a patient HIV-2 to protease inhibitors
A search method in a biological sample containing an HIV 2 viral strain for possible resistance of said strain to treatment by an anti-protease agent, and nucleotide probes for the implementation...
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7629437 |
Fluorogenic materials and uses thereof
A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended...
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7625713 |
Process for identifying a ligand that binds to the NEP binding site for the SMR1 pentapeptide
A process for screening for a ligand molecule that possesses an agonist biological activity on the NEP binding site for an SMR1 peptide, such as the QHNPR (SEQ ID NO: 2) pentapeptide. The method...
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7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
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7534582 |
Method for measuring the amount of natriuretic peptides in a sample
A method for accurately measuring an amount of natriuretic peptides in a sample that has stood for at least 24 hours, in a plastic tube or a tube coated with silicone. This method makes it possible...
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7534426 |
Glutenase enzyme assays
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of...
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7524934 |
Human brain carboxypeptidase B antibodies
A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. Antibodies against the...
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7497996 |
Liquid delivery apparatus and liquid delivery method
A liquid delivery apparatus 1 has a rotary substrate 2 . The substrate 2 formed with a fluid passage 8 A for communicating a supply chamber 6 A and target chamber 7 A. An inlet end portion ...
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7452690 |
Protease EFC cell surface fusion protein assay
Methods and reagents are provided for measuring protease activity. The reagent comprises a surface to which is linked an enzyme donor fragment through a protease recognition sequence, where the...
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7445907 |
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells)...
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7432071 |
Method of diagnosing periodontitis by determining γ-glutamyltranspeptidase
The inventor discovered that γ-GTP (γ-glutamyl transpeptidase) was scarcely contained in the gingival crevicular fluid of patients with gingivitis, but was contained in the gingival crevicular...
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7427498 |
Composition, methods and reagents for the synthesis of a soluble form of human PHEX
This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to...
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7425425 |
Method for the detection of enzyme-catalyzed cleavage reactions by fluorescence spectroscopy
A method involves the detection of enzyme-catalyzed cleavage reactions using modular chemical compounds as substrates for the enzymes involved, and detection is effected by use of...
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7422867 |
Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7405280 |
Chromogenic substances and use thereof for the determination of carboxypeptidase activities
The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a...
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7402407 |
Chemically targeted positional identification of post-translationally phosphorylated peptides
Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in...
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7402423 |
Apparatus for the detection of pepsin
An apparatus for detecting pepsin comprising a solid support, and a peptide chain wherein the peptide chain is operatively configured to be cleaved by pepsin, and the peptide chain is disposed on a...
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7384758 |
Bioluminescent protease assay with modified aminoluciferin or derivatives thereof
A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay...
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7358088 |
Peptides and compositions which modulate apoptosis
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7344852 |
Crystallization of dipeptidyl peptidase IV (DPPIV)
Provided are crystals relating to DPPIV and its various uses.
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7338777 |
Method for determining the biological activity of defibrotide
Method for determining the biological activity of defibrotide by a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides...
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7332296 |
Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry
The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying...
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7329507 |
Prodrug compounds with isoleucine
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a...
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7329506 |
Apparatuses and methods for determining protease activity
The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease...
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7320878 |
Protease assay for therapeutic drug monitoring
The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the...
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7312302 |
Compositions for the detection of enzyme activity in biological samples and methods of use thereof
The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated...
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7309578 |
Therapeutic treatment of chronic obstructive pulmonary disease
The present invention provides a method of treating or preventing a chronic obstructive pulmonary disease in a subject, comprising administering to said subject an amount of an agent affective to...
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7309580 |
Chromogenic plating medium for the rapid presumptive identification of Bacillus anthrasis, Bacillus cereus, and Bacillus thuringiensis
A plating medium for the presumptive identification of Bacillus cereus, Bacillus thuringiensis and/or Bacillus anthrasis that includes a nutrient base to facilitate growth of Bacillus cereus,...
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7291494 |
Regulation of target protein activity through modifier proteins
The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides...
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7279317 |
Modulation of COP9 signalsome isopeptidase activity
Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition,...
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7256013 |
Kit for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method...
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7238491 |
Pregnane X receptor method
The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene...
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7238483 |
Method for detecting catalytic activity
This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the...
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7223865 |
Chromogenic compounds, and use thereof as enzyme substrates
The present invention relates to novel chromogenic substrates which are used to detect aminopeptidase activity in microorganisms or to determine whether at least one bacterium belongs to the...
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7198896 |
Immunoaffinity isolation of modified peptides from complex mixtures
The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism,...
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7183070 |
Inhibition of Aβ production by β-secretase BACE2
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of...
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7169574 |
Fluorescence detection of proteases or peptidases
The invention concerns the use of a PyA-(Z) x -pNF group in a substrate for detecting, identifying and/or analyzing by fluorometry peptidases or proteases capable of cleaving the or a bond between...
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7163803 |
Method for characterizing polypeptides
Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping...
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7160683 |
Method of testing for bronchial asthma
SCCA1 and SCCA2 genes, whose expression were greatly changed in a plurality of cells by stimulating respiratory tract epithelial cells with IL-4 or IL-13, were obtained as allergy related genes....
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7157241 |
Serine protease genes related to DPPIV
Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins,...
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7153679 |
Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination...
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7153666 |
Methods and compositions for determination of glycated proteins
This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits...
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7148030 |
Bioluminescent protease assay
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
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7135306 |
Method of measuring homocysteine
A method for detecting or measuring homocysteine in a sample includes the steps of (a) reacting a D-amino acid present in a sample with a D-amino acid converting enzyme to convert the D-amino acid...
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7125701 |
Aggrecanase molecules
Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and...
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7125685 |
Stable isotope, site-specific mass tagging for protein identification
Proteolytic peptide mass mapping as measured by mass spectrometry provides an important method for the identification of proteins, which are usually identified by matching the measured and...
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7118877 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
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7105312 |
Ca2+/calmodulin-dependent protein kinase IV
The present invention relates to Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) and, in particular, to methods of screening compounds for their ability to act as CaMKIV agonists or...
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