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7598072 |
Assay to detect viral uncoating
A cell-free viral uncoating assay is provided.
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7598071 |
Infectious clone of human parvovirus B19 and methods
The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in...
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7592170 |
Selective precipitation of viruses using polyectrolytes
The invention provides new methods for purifying and concentrating viruses. The inventors have discovered that high molecular weight proteoglycans present in retroviral stocks are co-concentrated...
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7588929 |
Production of bacteriophage compositions for use in phage therapy
The present invention relates to the use of bacteriophages to treat infectious diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage...
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7585641 |
Immunoassay and method of use
A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The...
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7579181 |
Purification of adenovirus and AAV
The present invention relates to the purification of large scale quantities of active (infectious) adenovirus and AAV, especially for use in therapeutic applications. In particular, the invention...
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7579007 |
Production of “biological carriers” for induction of immune responses and inhibition of viral replication
This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus...
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7576323 |
Point-of-care mass spectrometer system
A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a...
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7575911 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
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7566562 |
Culturing circular ssDNA viruses for the production of vaccines
The present invention relates to the use of interferon in the in vitro cultivation of animal circular ssDNA virus such as Porcine Circovirus 2 or human TT virus in an animal cell line. Increased...
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7556940 |
Assembly of wild-type and chimeric influenza virus-like particles (VLPs)
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA,...
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7524676 |
Large scale productions of virus antigen
The present invention provides improved methods of production of viral antigen on a culture of adherent cells bound to a microcarrier, wherein the methods provide for increased viral antigen yield...
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7521219 |
Method of producing baculovirus
The present invention is directed to a method for producing commercial quantities of baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in...
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7521201 |
Bacteriophages as selective agents
Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages...
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7510872 |
Recombinant adeno-associated virus production
The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, the invention relates to use of recombinant adenovirus encoding...
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7510862 |
Polynucleotide fragments of an infectious human endogenous retrovirus
Described is a polynucleotide molecule being a fragment of a polynucleotide sequence of an infectious human endogenous retrovirus, said polynucleotide molecule comprising a sequence selected from...
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7494813 |
VAC-BAC shuttle vector system
The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
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7465574 |
Recombinant RSV virus expression systems and vaccines
The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present...
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7465397 |
Process for removing protein aggregates and virus from a protein solution
A process is provided for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process. Preferably, it relates to a process for selectively removing...
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7456008 |
Modified virus comprising one or more non-native polypeptides
A modified virus including one or more non-native polypeptides, and the use of such viruses in therapy, particularly in the treatment of tumours or other cancerous cells are disclosed. The...
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7439058 |
HBV/HCV virus-like particle
Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface...
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7429485 |
Method of producing infectious reovirus
A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides...
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7425437 |
Vaccines against West Nile Virus
The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived therefrom, produced on human cells, wherein the human cells...
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7419817 |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
The present invention provides methods of purifying adeno-associated virus (AAV) particles. These AAV particles include AAV2, AAV4 and AAV5 particles. The present invention also provides AAV...
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7413889 |
Production of a parvovirus vaccine in plants as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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7393527 |
Method for limiting the growth of cancer cells using an attenuated measles virus
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the...
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7361496 |
Rescue of mumps virus from cDNA
This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom....
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7344723 |
Self-replicating RNA molecule from hepatitis C virus
A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that...
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7338759 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7332176 |
Solenopsis invicta viruses
Unique Solenopsis invicta viruses (SINV) have been identified and their genome sequenced. Oligonucleotide primers have been developed using the isolated nucleic acid sequences of the SINV. The...
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7326555 |
Methods of adenovirus purification
A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of...
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7314746 |
Apparatus and method for preparative scale purification of nucleic acids
Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular...
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7300785 |
Culturing circular ssDNA viruses for the production of vaccines
The present invention relates to the use of interferon in the in vitro cultivation of animal circular ssDNA virus such as Porcine Circovirus 2 or human TT virus in an animal cell line. Increased...
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7294500 |
Mosaic infectious bursal disease virus vaccines
The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable...
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7291498 |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing...
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7285424 |
Membrane-based assay devices
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g.,...
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7270990 |
Virus production
An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from...
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7264958 |
Method for obtaining a purified viral preparation
The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step...
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7264923 |
Norovirus infected cell cultures and uses therefor
A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and...
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7252984 |
Attenuated mutant newcastle disease virus strains for in ovo vaccination, method for preparing and their use
The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains suitable for in ovo vaccination of avian species comprising a mutation in the gene...
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7244558 |
Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines
The present invention concerns cDNAs for making attentuated, infectious Newcastle disease virus (NDV). Another aspect of the invention relates to methods of making the cDNAs. Another aspect of the...
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7235394 |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in...
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7235393 |
Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
A method for isolating AAV viruses from cellular DNA of non-human primate (NHP) tissues by transfecting the DNA of NHP into 293 cells, rescuing the virus and amplifying it through serial passages...
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7235391 |
Formulation of adenovirus for gene therapy
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use...
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7235235 |
Alphavirus RNA replicon systems
The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper...
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7232680 |
Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a...
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7226775 |
Method of removing endotoxin from vaccines
A method of removing bacterial endotoxin from a pharmaceutical process solution is disclosed. In one embodiment, the method comprises treating the solution with a surfactant effective to dissociate...
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7223595 |
Use of purified Streptomyces griseus trypsin for production of a biomass of cells and viral propagation
The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the...
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7223585 |
Viral purification methods
The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of...
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7223584 |
Recombinant rabies vaccine and methods of preparation and use
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of...
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