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7611831 |
Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7556814 |
Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane
An antigenic and immunogenic composition of predetermined inactivated strains of human immunodeficiency virus (HIV) is disclosed. Inactivation is through psoralen and ultraviolet radiation; the...
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7521219 |
Method of producing baculovirus
The present invention is directed to a method for producing commercial quantities of baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in...
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7494799 |
Paramunity inducers based on attenuated rabbit myxoma virus
The invention relates to monoparamunity inducers that are based on paramunizing viruses or viral components of a myxoma virus strain of diseased rabbits that show general symptoms of the disease....
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7482149 |
Inhibition of SARS coronavirus infection with clinically approved antiviral drugs
The invention relates to methods for treating or inhibiting SARS-CoV infection involving the administration of an interferon, particularly IFN α-n1, IFN α-n3, human leukocyte IFN α or IFN β-1b.
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7482115 |
Immobilisation and stabilisation of virus
The present invention relates to a method for immobilization and optional stabilization of viruses whilst retaining the viral biological activity and the use of immobilized virus in therapy. In...
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7425437 |
Vaccines against West Nile Virus
The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived therefrom, produced on human cells, wherein the human cells...
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7413889 |
Production of a parvovirus vaccine in plants as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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7354190 |
Two-stage mixing system, apparatus, and method
A two-stage mixing system, apparatus, and method produces a solution including a first substance and a second substance in a predetermined ratio by first mixing the first substance with a first...
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7223410 |
Inactivated respiratory syncytial viral vaccines
An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is...
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RE39494 |
Inactivated mycoplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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7129223 |
Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference...
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7094378 |
Method and apparatus for inactivation of biological contaminants using photosensitizers
Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein,...
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7056507 |
Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method
An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7037642 |
Removing compounds from blood products with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7033813 |
Inactivated vaccines for aids and other infectious diseases
Presented herein is a description for the manufacturing of inactivated HIV for use in vaccines against AIDS, as well as other inactivated viruses for other infectious diseases. This invention...
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7026154 |
Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of...
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7008784 |
Non-infectious, non-replicating, immunogenic human immunodeficiency virus-like particles
The present invention is directed toward methods for the production of non-infectious, replication-deficient, immunogenic human immunodeficiency virus (HIV)-like particles. These particles are...
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6991899 |
Cells for detection of influenza and parainfluenza viruses
The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells...
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6989263 |
Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
The present invention provides several classes of compounds which can be used to inactivate retroviruses, such as HIV-1, by attacking the CCHC zinc fingers of the viral nucleocapsid protein and...
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6967239 |
Method of filtering viruses from a factor VIII solution
Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting...
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6951713 |
Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the...
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6893856 |
Process for preparing virus-inactivated factors 1X and X by membrane chromatography
Disclosed is a process for preparing agents containing virus-inactivated vitamin K-dependent plasma components as well as protein C, protein S, factors II, VII, IX and/or X as well as combinations...
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6838080 |
Induction of immunoglobulin class switching by inactivated viral vaccine
The present disclosure provides methods and compositions for inducing an immune response to an antigen, especially in an immunogenic composition comprising sialic acid where the antigen comprises...
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6825027 |
Method of production of purified hepatitis a virus particles and vaccine preparation
The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present...
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6805870 |
Paramunity inducer based on combinations of poxvirus components, process to prepare it and its use as medicament
Multipotent paramunity inducers are described which are based on combinations of poxvirus components derived from various poxviruses with paramunizing properties and which have been improved in...
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6800432 |
Apparatus and method for inactivating viral contaminants in body fluids
A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container...
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6720136 |
Solid phase quenching systems
Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino...
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6705556 |
Composition and method for inducing tolerance to viral infection in aquatic animals
The White Spot Syndrome Virus (WSSV) is a virus affecting shrimps as well as other crustaceans, and the WSSV epidemic poses a serious threat to the shrimp farming industry. The present invention...
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6660272 |
Porcine circoviruses, vaccines and diagnostic reagents
The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It...
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6653081 |
Methods for monitoring antiretroviral therapy and guiding therapeutic decision in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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6558678 |
PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS
Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains...
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6528246 |
Method for the inactivation of non-lipid-coated viruses
A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source,...
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6521601 |
Method and composition for inhibition of viral replication
A method and pharmaceutical composition for inhibiting viral replication in infected cells are described. The pharmaceutical composition includes a DNA fragment which has covalently linked strands....
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6503699 |
Method for photodecontamination of pathogens in blood using 5'-primary aminopsoralens
Psoralen compound compositions are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction...
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6471965 |
Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque
A vaccine is disclosed for the prophylaxis against pathogenic development of atherosclerotic plaque in a mammalian subject susceptible thereto which consists essentially of a multiplicity of killed...
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6468778 |
Process for the inactivation of viruses
A process for the inactivation and/or elimination of coated and/or noncoated viruses from a plasma protein solution by addition of an ammonium salt at alkaline pHs is described, in which a...
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6465168 |
Methods and apparatus for the inactivation of viruses
The present invention is directed to methods and apparatus for inactivating viruses associated or potentially associated with blood derived samples. The process and apparatus feature critical,...
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6455036 |
Granulated formulation and method for stabilizing biocontrol agents
A stabilized, granular, biocontrol agent formulation for agricultural pests relies upon a combination of a water absorbent material, a membrane stabilization agent, and a granulating agent to...
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6444458 |
Use of tagetes minuta oil and its components as antiviral agents
This invention relates to an antiviral composition for the treatment of plant viruses comprising an effective amount of Tagetes minuta oil, its active constituents, Z-β-ocimene and...
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6436402 |
Process for making human papillomavirus virus-like particles with improved properties
Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The...
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6428819 |
Plant extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
The use of extracts from the plant Hypericum perforatum in the preparation of pharmaceutical compositions for the treatment of hepatitis C, chronic hepatitis C and related viruses, said...
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6426070 |
Methods for inactivating enveloped RNA virus particles and compositions for use therewith
A method for inactivating a virion of an enveloped RNA virus comprising contacting the virion with an eosinophil-derived ribonuclease, such as eosinophil-derived neurotoxin (EDN) or eosinophil...
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6410570 |
Methods of inactivating a virus and controlling viral replication
An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents...
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6410219 |
Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for...
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6399356 |
Process and agent for sanitation of contaminations caused by viruses
A process and an agent for the sanitization of tissues or cell cultures and also of materials and equipment which can be contaminated with viruses are described. For sanitization, a solution of a...
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6399355 |
Non-naturally occurring targeted lipolytic compounds and related compositions and methods
This invention provides a non-naturally occurring targeted lipolytic compound comprising a lipolytic agent linked to a targeting agent. In an embodiment, the lipolytic agent is covalently attached...
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6346408 |
Method of allophycocyanin inhibition of enterovirus and influenza virus reproduction resulting in cytopathic effect
A method of allophycocyanin inhibition of enterovirus and influenza virus reproduction resulting in cytopathic effect, with the ingredients utilized including allophycocyanin, wherein a virus and...
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6346277 |
Process for the pasteurization of plasma or concentrates of blood coagulation factors II, VII, IX and X
The present invention relates to a process for the preparation of a product of blood coagulation factors II, VII, IX and X which is virtually free of virus, the process comprising heating an...
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