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7618802 |
Compositions of coronaviruses with a recombination-resistant genome
The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are...
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7601356 |
Methods and compositions for increasing replication capacity of an influenza virus
In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza...
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7588769 |
Viruses encoding mutant membrane protein
A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided.
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7579007 |
Production of “biological carriers” for induction of immune responses and inhibition of viral replication
This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus...
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7572455 |
Vaccine comprising an attenuated pestivirus
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein E rns and at least another mutation in the coding sequence for N...
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7563449 |
Methods for reducing cattle reproductive diseases
The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV)...
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7560118 |
Attenuated dengue virus comprising mutations in the NS3 gene
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
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7556957 |
Coronavirus-like particles comprising functionally deleted genomes
The invention relates to the field of coronaviruses and diagnosis, therapeutic use, and vaccines derived therefrom. The invention provides replicative coronaviruses and virus-like particles (VLPs)...
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7556940 |
Assembly of wild-type and chimeric influenza virus-like particles (VLPs)
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA,...
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7556814 |
Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane
An antigenic and immunogenic composition of predetermined inactivated strains of human immunodeficiency virus (HIV) is disclosed. Inactivation is through psoralen and ultraviolet radiation; the...
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7544362 |
N protein mutants of porcine reproductive and respiratory syndrome virus
The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified...
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7517531 |
Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3′-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4
The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4,...
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7510863 |
Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making
The present invention is directed to novel avian pneumovirus strain Colorado (APV/CO) genes and intergenic sequences. Also disclosed are methods of making recombinant avian pneumovirus and...
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7510862 |
Polynucleotide fragments of an infectious human endogenous retrovirus
Described is a polynucleotide molecule being a fragment of a polynucleotide sequence of an infectious human endogenous retrovirus, said polynucleotide molecule comprising a sequence selected from...
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7507415 |
West nile virus vaccine
The invention provides chimeric flavivirus vaccines against West Nile virus and methods of using these vaccines to prevent or treat West Nile virus infection.
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7494799 |
Paramunity inducers based on attenuated rabbit myxoma virus
The invention relates to monoparamunity inducers that are based on paramunizing viruses or viral components of a myxoma virus strain of diseased rabbits that show general symptoms of the disease....
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7491400 |
Pharmaceutical compositions comprising attenuated HIV-1 nef-deficient viral particles
A therapeutic suspension for the treatment of human immunodeficiency virus type I (HIV-1) infection in humans using isolated and purified HIV-1 nef-deficient viral particles having a nef-deletion...
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7491399 |
In Ovo vaccine against infectious bursal disease
The present invention relates to a non pathogenic vaccine comprising a recombinant Infectious Bursal Disease virus that includes a recombinant Segment A, designated as rD78GLSNSΔ, that includes...
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7476389 |
Papillomavirus vaccines
A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in related to infections caused by papilloma virus. The...
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7465574 |
Recombinant RSV virus expression systems and vaccines
The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present...
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7452542 |
Live attenuated coronavirus vaccines
The present invention is directed live, attenuated coronavirus vaccines. The vaccine comprises a viral genome encoding a p59 protein having at mutation at a specific tyrosine residue, and may...
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7439058 |
HBV/HCV virus-like particle
Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface...
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7419816 |
Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies and gene therapy in the CNS
A mutant virus contains a mutation at a phosphorylation site in one or more viral proteins, which attenuates the virus, and an improved vaccine composition. The invention also relates to methods of...
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7413889 |
Production of a parvovirus vaccine in plants as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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7393527 |
Method for limiting the growth of cancer cells using an attenuated measles virus
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the...
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7384643 |
Recombinant poxvirus
Use for novel chemokine-binding protein designated A41L, and chemokine-binding fragments thereof, for the treatment of conditions such as inflammation. The A41L protein binds to chemokines in the...
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7374768 |
Viral vaccines
A mutant virus for use as a vaccine for prophylaxis or therapy, wherein the genome of the virus is defective in respect of a gene essential for the production of infectious virus. In one aspect the...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7351527 |
Immunizing fish against viral infection
The present invention provides the isolated causative agent of the disease affecting Cyprinus carpino and a method for its isolation. The invention further provides avirulent forms, e.g.,...
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7344723 |
Self-replicating RNA molecule from hepatitis C virus
A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that...
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7335364 |
Modified Vaccinia Ankara virus variant
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell...
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7332322 |
Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof
The present invention provides a Venezuelan equine encephalitis virus replicon RNA useful in the development of stable lines of mammalian, avian and insect cells in which these replicons will...
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7309493 |
Inactivated bovine scours vaccines, process and method of preventing bovine scours
Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of...
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7285381 |
Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same
The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also...
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7276333 |
Viral infection inhibitor targeting integrase N-terminal domain
The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a...
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7252984 |
Attenuated mutant newcastle disease virus strains for in ovo vaccination, method for preparing and their use
The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains suitable for in ovo vaccination of avian species comprising a mutation in the gene...
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7244558 |
Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines
The present invention concerns cDNAs for making attentuated, infectious Newcastle disease virus (NDV). Another aspect of the invention relates to methods of making the cDNAs. Another aspect of the...
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7244434 |
Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing...
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7238672 |
Chimeric lyssavirus nucleic acids and polypeptides
The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a ...
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7235235 |
Alphavirus RNA replicon systems
The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper...
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7229625 |
Retrovirus-like particles made non-infectious by a plurality of mutations
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product,...
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7223584 |
Recombinant rabies vaccine and methods of preparation and use
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of...
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7211378 |
Filovirus vectors and noninfectious filovirus-based particles
Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
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7211260 |
Infectious bursitis vaccine
The present invention is concerned with isolated infectious bursitis (or bursal) disease virus(es) and a vaccine containing said virus(es) which is capable of protecting poultry against disease...
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7189401 |
Live attenuated viruses for use as vectors or vaccines
The present invention provides modified viral genomes for use as vaccines or vectors, which are improved in their ability to retain attenuating mutations. The genomes are from viruses that...
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7186543 |
Preparation of vaccines using a photosensitizer and light
Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective,...
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RE39494 |
Inactivated mycoplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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7157266 |
Structure of adenovirus bound to cellular receptor car
Disclosed is a mutant CAR-DI-binding adenovirus which has a genome comprising one or more mutations in sequences which encode the fiber protein knob domain wherein the mutation causes the encoded...
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7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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7150984 |
Attenuated human rotavirus vaccine
The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating...
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