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7005130 |
Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E
The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns...
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7001765 |
Adeno-associated virus vector for boosting immunogenicity of cells
The present invention provides an Adeno-Associated Virus (AAV) vector having a foreign DNA coding for a protein that boosts immunogenicity of cells. The invention also provides a vaccine containing...
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7002057 |
Thioredoxin H homologs
This invention relates to an isolated nucleic acid fragment encoding a thioredoxin protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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7001764 |
Compositions comprising tissue specific adenoviral vectors
Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene...
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6998263 |
Methods of preparing and using a viral vector library
The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene...
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6998252 |
Recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus...
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6995006 |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene...
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6995009 |
Packaging cell
A virus-producing cell sustaining the ability to produce viruses at high titer is successfully constructed by expressing the virus structural gene under the regulation of EF1α promoter. In this...
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6991929 |
Hepatitis A vaccines
A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a...
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6991935 |
Target cell-specific adenoviral vectors containing E3 and methods of use thereof
The invention provides adenoviral vectors (preferably replication competent) comprising both an E3 sequence and at least one adenoviral gene under transcriptional control of a target cell-specific...
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6991899 |
Cells for detection of influenza and parainfluenza viruses
The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells...
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6984517 |
AAV5 vector and uses thereof
The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid...
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6984490 |
Identification of genes
A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of:
(1) providing a plurality of microorganisms each of which is...
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6982087 |
Vectors derived from South African Arbovirus No. 86
Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral...
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6982160 |
Immunogenic compositions that include SIRS virus
The invention includes kits for producing and using immunogenic compositions that include swine infertility and respiratory virus. The invention also includes vaccines and sera for treatment of...
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6979534 |
Compositions and methods for detection of antibody binding to cells
The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on...
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6979568 |
Vector for the expression of two foreign genes
A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be...
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6979732 |
Polynucleotide compositions encoding S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase and methods for modulating lipid biosynthesis in plants
Disclosed are compositions and methods for increasing the nutritional value of plants and plant parts. In illustrative embodiments PEAMT and ΔPEAMT polynucleotide and polypeptide compositions are...
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6977079 |
Avian pneumovirus vaccine
Compositions and methods for ameliorating the clinical signs of an avian pneumovirus (APV) infection in a bird are disclosed. The compositions include immunologically effective amounts of an...
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6974866 |
Retrovirus from the HIV type O and its use (MVP-2901/94)
A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V...
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6969610 |
Methods of modifying cell structure and remodeling tissue
Disclosed is a method of modifying cell structure which includes: increasing the intracellular concentration of biliverdin reductase, or a fragment or variant thereof, in a mammalian cell under...
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6969583 |
Method for detecting variant HBV
The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a...
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6967075 |
HCV replicase complexes
This invention provides efficient HCV replicase complexes comprising novel RNA template and primer pair. Assay systems are also provided, which use such complexes, for detecting replicase activity,...
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6967076 |
Method for producing recombinant cells for detecting HIV
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6964845 |
Thermostable phage lambda operator mutants for regulating gene expression
The present invention concerns a method for selecting New P R or P L operator sequences from lambdoid phages which have different thermostability compared to the wild-type sequence with regard to...
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6964852 |
Antigenic structural peptide, antigenic and immunogenic compounds, and uses for detecting, preventing and treating an HCV infection
The invention concerns a structural peptide, identified by antibodies directed against a polypeptide, comprising the 2-45 amino acid sequence of the N-terminal end of the Core or nucleocapsid (p21)...
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6962777 |
IN VITRO METHOD FOR DISASSEMBLY/REASSEMBLY OF PAPILLOMAVIRUS VIRUS-LIKE PARTICLES (VLPS), HOMOGENEOUS VLP AND CAPSOMERE COMPOSITIONS PRODUCED BY SAID METHODS; USE THEREOF AS VEHICLE FOR IMPROVED PURIFICATION, AND DELIVERY OF ACTIVE AGENTS
A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful...
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6962708 |
Chimeric flavivirus vaccines
A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional...
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6958237 |
Highly infectious rubella virus DNA constructs and methods of production
Highly infectious rubella virus cDNA clones derived from infectious cDNA clone having a low specific infectivity and methods of obtaining highly infectious rubella virus cDNA clones. Togavirus...
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6958235 |
Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19)...
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6958226 |
Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins
Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using...
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6956113 |
Bioluminescent assays and bacterial strains useful therein
The present invention relates to novel assays for assessing the degree to which a cell is metabolically active. Also provided, are mutagenicity assays and, more specifically, methods for...
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6953579 |
Chimeric virus-like particle or chimeric capsomers from BPV
The present invention relates to chimeric virus-like particles (cVLPs) or chimeric capsomers (cCs) from BPV, fusion proteins and DNAs coding for said proteins and to the use of cVLPs or cCs for the...
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6953661 |
Method of preventing transport of a neurotropic virus and identifying agents for achieving same
A method of preventing transport of a Herpes simplex virus within a neuron, comprising preventing interaction between a structural tegument protein US11 of the virus and a motor protein, Kinesin in...
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6951753 |
Helper-free stocks of recombinant adeno-associated virus vectors
A method for producing helper-free stocks of recombinant adeno-associated virus (rAAV) which can be used to efficiently and stably transduce foreign genes into host cells or organisms. The method...
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6951752 |
Method for large scale production of virus antigen
The present invention provides improved methods of production of viral antigen on a culture of adherent cells bound to a microcarrier, wherein the methods provide for increased viral antigen yield...
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6951755 |
Vectors and methods for gene transfer
The present invention provides a recombinant adenovirus comprising coat proteins that lack native binding. In particular, the present invention provides a recombinant adenovirus comprising a penton...
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6949353 |
Capping enzyme of flavivirus and utilization of this protein in a process to test drugs with antiviral properties
This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also...
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6949512 |
Therapeutic agent for the treatment of septicaemia its preparation and use
A therapeutic agent for the treatment of septicemia, its preparation and use, with application in the pharmaceutical industry and medicine. This therapeutic agent contains essential element, the...
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6946126 |
Replicating adenovirus vectors
The present invention provides replicating [100K−] adenovirus vectors that have an impairment in 100K activity. In particular preferred embodiments, the impairment is the result of a deletion in...
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6943012 |
Helper dependent adenoviral vector system and methods for using the same
A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human...
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6943019 |
Methods and vector constructs useful for production of recombinant AAV
Methods for efficient production of recombinant AAV employ a host cell containing a first nucleic acid molecule comprising from 5′ to 3′, a parvovirus P5 promoter, a spacer, an AAV rep sequence...
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6942864 |
Leporipox-based vector vaccines
The present invention is directed to the use of a live, recombinant leporipox virus comprising exogenous DNA, which is operably linked to at least one expression control element and which is...
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6940003 |
Plan lecithin: cholesterol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding a plant lecithin: cholesterol acyltransferases. The invention also relates to the construction of a chimeric gene encoding all...
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6936466 |
Transcriptionally-activated AAV inverted terminal repeats (ITRs) for use with recombinant AAV vectors
This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large...
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6933108 |
Methods and compositions for use in the treatment of filovirus mediated disease conditions
Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least...
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6933377 |
Compositions comprising multiple immunodeficiency virus subunits for inducing an immune response
The present invention relates to prophylactic and therapeutic acquired immunodeficiency syndrome vaccines. In particular, the present invention provides methods and compositions utilizing...
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6930095 |
Hepatitis C virus constructs characterized by high efficiency replication
The present invention relates to recombinant hepatitis C virus (HCV)-derived nucleic acids and to stable rapidly growing cell clones derived from human hepatoma Huh-7 cell line and supporting high...
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6924415 |
Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy
The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its...
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6924137 |
Method for virus propagation
The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased...
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