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7067245 |
Selection methods
A rational method for obtaining a novel molecule capable of a desired interaction with a substrate of interest comprising selecting hosts or replicators which encode said novel molecules based upon...
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7063851 |
Herpes viruses for immune modulation
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
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7063835 |
Virus strains
The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus...
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7063949 |
Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic...
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7060467 |
Recombinant proteins containing repeating units
Methods for the production of recombinant proteins containing repeating units are disclosed. Also disclosed are methods for the production of degenerate polynucleotides encoding said recombinant...
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7056507 |
Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method
An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and...
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7052899 |
Toxoplasma gondii proteins, nucleic acid molecules, and uses thereof
The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such...
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7052830 |
Hepatitis C virus peptides and uses thereof
Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine...
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7049425 |
Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor
A new variant of the sigma-1 (σ 1 )receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma— 1β (σ...
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7049145 |
Vaccinia virus MVA-E3L-knockout-mutants and use thereof
The present invention relates to mutant MVA vaccinia viruses, which are used for the generation of recombinant MVA viruses, as well as host cells, which have been infected with these mutant MVA...
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7049135 |
Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore,...
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7049428 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7049134 |
Rolling circle replicon expression vector
A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements...
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7045344 |
Adenoviral vector and methods for making and using the same
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
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7045335 |
Alphavirus replicon vector systems
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent...
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7045313 |
Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
Methods and compositions are provided for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes. Expression of foreign genes is obtained by combining vaccinia...
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7045347 |
Helper dependent adenovirus vectors based on integrase family site-specific recombinases
This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase...
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7041500 |
Insect cell line
An insect cell line capable of growth in serum-free media and secretion of high levels of recombinant proteins, including virus-like particles, upon infection with recombinant baculoviruses, is...
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7041489 |
Recombinant respiratory syncytial viruses with deleted surface glycoprotein genes and uses thereof
The present invention provides recombinant respiratory syncytial viruses (RSV) in which all of the surface glycoprotein genes encoding the attachment protein G, the fusion protein F, and the Small...
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7041439 |
Methods and apparatus for selectively processing eggs having identified characteristics
Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to...
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7041813 |
Canine herpes virus alpha transinducing factor nucleic acid molecules
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid...
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7037723 |
Recombinant herpes viruses for preparing recombinant adeno-associated viruses
The invention relates to a recombinant herpes virus which contains the rep and cap genes of the adeno-associated virus, and to a method for producing high-titer, highly infectious adeno-associated...
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7037648 |
Somatic transfer of modified genes to predict drug effects
The present invention relates to somatic cell gene transfer methods for mimicking one or more effects of a drug candidate compound. In one aspect, the methods mimic the effect of a drug candidate...
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7037508 |
Pestivirus mutants and vaccines containing the same
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region...
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7038014 |
Polycation-sensing receptor in aquatic species and methods of use thereof
Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.
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7037662 |
Receptor-ligand system and assay
An Eph family RTK (receptor tyrosine kinase) ligand-binding domain as well as a method of identifying Eph family RTK agonists or antagonist. The ligand-binding domain is suitably encoded by exon...
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7037506 |
Vaccine accelerator factor (VAF) for improvement of vaccinations in poultry
The present invention provides a vaccine accelerator factor (VAF) which is an in ovo nucleotide immuno-stimulant. The VAF contains one or more DNA constructs, each having a DNA molecule and a...
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7038035 |
Vaccine-induced hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is...
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7037707 |
Method for generating influenza viruses and vaccines
The present invention is based on the discovery that a high titer reassortant influenza virus is produced in mammalian cell culture by replacing the NS gene of the A/PuertoRico/3/24 master strain...
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7034141 |
Packaging of positive-strand RNA virus replicon particles
The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the...
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7033750 |
Recombinant P53 adenovirus methods and compositions
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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7033749 |
Ribonuclease resistant RNA preparation and utilization
The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
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7033835 |
Production of peptides in plants as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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7029848 |
High throughput screening of gene function using libraries for functional genomics applications
Novel means and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or...
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7029861 |
LPS-response gene compositions and methods
The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation...
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7025968 |
CMV vaccines
The invention provides methods and compositions for inhibiting CMV infection and dissemination in an animal, as well as in vitro and in vivo assay systems for identifying such compositions.
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7026154 |
Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of...
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7025967 |
Recombinant protein production in bovine adenovirus expression vector system
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted...
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7022327 |
Recombinant birnavirus vaccine
The present invention provides a birnavirus mutant which is suited as vaccine candidate in eradication control programmes. The mutant is not able to produce a native VP5 protein, and this feature...
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7019122 |
Unusual retrotransposon from the yeast Candida albicans
TCa2 is a Tyl/copia retrotransposon from the pathogenic yeast Candida albicans . In contrast to other retrotransposons it can appear as an abundant, extrachromosomal double-stranded DNA molecule,...
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7018826 |
Particles for gene therapy
The present invention relates to particles, comprising: a protein envelope with a fusion protein, which comprises a virus protein, a cell permeability-mediating peptide and a heterologous...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7015026 |
Purification of adenovirus and AAV
The present invention relates to the purification of large scale quantities of active (infectious) adenovirus and AAV, especially for use in therapeutic applications. In particular, the invention...
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7015024 |
Compositions containing recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus...
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7011968 |
Fragments of virus protein 2 or 3 of the polyoma virus, used for transporting active ingredients
The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid...
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7011836 |
Mutants of gram negative mucosal bacteria and application thereof in vaccines
It is possible to inactivate the early stage of lipid A synthesis of mucosal gram negative bacteria without compromising cell viability. In particular the lpxA gene in N. meningitidis was mutated...
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7009044 |
HCV/BVDV chimeric genomes and uses thereof
The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV)....
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7008621 |
Regulation of apoptosis in aquatic organisms by aquabirnavirus
The present invention provides a mechanism for studies of apoptosis in aquatic organisms by infecting the aquatic organisms with aquabirnavirus, especially infectious pancreatic necrosis virus...
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7005130 |
Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E
The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns...
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