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7220852 |
Coronavirus isolated from humans
Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV...
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7217807 |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “genomic record” or...
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7217793 |
Sphingomyelin detecting probe
Proteins useful as sphingomyelin detecting probes, which specifically recognize sphingomyelin and have low cytotoxicity. The proteins of the present invention may be obtained by deletion of between...
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7211391 |
Methods and compositions for predicting the outcome of cervical intra-epithelial neoplasia
The present invention relates to methods and kits for predicting the outcome of cervical intra-epithelial neoplasia and methods for treating a cervical intra-epithelial neoplasia. More...
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7211426 |
Isolated phages and their use in food or pet food products
The present invention relates to phage isolates having a strong lytic activity against pathogenic Enterobacteriaceae such as Escherichia coli and/or Salmonella strains and their use in various...
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7208161 |
Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a...
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7205101 |
Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7205398 |
Eta-1 gene and methods for use
The present application relates to osteopontin (Eta-1) polypeptides, nucleic acids that encode Eta-1, antibodies that specifically bind to Eta-1, and methods for enhancing an immune response in an...
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7205126 |
Papilloma pseudovirus and preparation
The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by...
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7198934 |
Recombinant MVA virus, and the use thereof
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the...
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7198935 |
Infectious pestivirus pseudo-particles containing functional Erns, E1, E2 envelope proteins
The invention relates to the generation and the use of pestivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto retroviral core particles. These...
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7198951 |
Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of...
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7192740 |
Recombinant viral nucleic acids
The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic...
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7193049 |
PRO862 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7189506 |
DNA binding compound-mediated molecular switch system
The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response...
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7189401 |
Live attenuated viruses for use as vectors or vaccines
The present invention provides modified viral genomes for use as vaccines or vectors, which are improved in their ability to retain attenuating mutations. The genomes are from viruses that...
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7189820 |
Antibodies against tumor necrosis factor delta (APRIL)
The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and...
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7186542 |
Method of extracting virus from cell culture
The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a...
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7186504 |
Cells for detection of enteroviruses
The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo...
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7186506 |
Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7183107 |
Enhanced replication of HCV RNA
This invention provides methods of generating cells that stably replicate sub-genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and...
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RE39494 |
Inactivated mycoplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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7183095 |
Cell culture system for synthesis of infectious hepatitis C virus
The invention rates to a hepatitis C virus (HCV) cDNA-based culture system capable of synthesis of infectious HCV in cell culture and cell-to-cell spread of the virus. The invention also relates to...
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7176286 |
Antigen fragments for the diagnosis of Toxoplasma gondii
The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented...
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7175983 |
Adapter-directed display systems
The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic...
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7176020 |
EBV-infected stomach cancer cell line
An EBV strain infecting epithelial cells and a stomach cancer cell line cancerated by EBV are established to clarify the mechanism of canceration of epithelial cells into stomach cancer by EBV and...
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7172893 |
Virus vectors and methods of making and administering the same
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a...
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7166426 |
HCV assay
An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an...
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7166713 |
Variant cleavage stimulation factor and its encoding nucleic acid
The present invention relates to an isolated human nucleic acid molecule encoding a protein or polypeptide which controls RNA polyadenylation, an isolated mouse nucleic acid molecule encoding a...
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7163818 |
Bacteriophage having multiple host range
The present invention discloses compositions and methods for the prophylaxis and treatment of bacterial infections by the use of polyvalent bacteriophage having multiple host range.
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7160685 |
Diagnostic reagents for human cytomegalovirus and methods of use
The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8 + class I MHC restricted cytotoxic T-lymphocytes...
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7157568 |
Human estrogen receptor-β
The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-β (hERβ), which comprises 530 amino acids. The invention also provides isolated hERβ...
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7157225 |
Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens
An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies...
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7157266 |
Structure of adenovirus bound to cellular receptor car
Disclosed is a mutant CAR-DI-binding adenovirus which has a genome comprising one or more mutations in sequences which encode the fiber protein knob domain wherein the mutation causes the encoded...
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7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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7150874 |
Vector for integration of heterologous sequences into poxviral genomes
A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are...
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7147848 |
Recombinant poliovirus for the treatment of cancer
The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are...
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7144578 |
Poxvirus-rabies recombinants and compositions and methods employing the recombinants
Recombinant viruses containing DNA coding for a rabies virus antigen, such as rabies virus G are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The...
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7144712 |
Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7141405 |
Chimeric GB virus B (GBV-B)
The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of GB virus B (GBV-B)/HCV chimeras. The...
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7138231 |
Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7138252 |
Molecular antigen arrays
The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant...
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7135282 |
Viral particles with exogenous internal epitopes
The present invention relates to the expression of peptides on viral particles, and more particularly to the expression of peptides on the interior or the viral capsid. Methods are described for...
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7135339 |
Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)
The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to...
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7135187 |
System for production of helper dependent adenovirus vectors based on use of endonucleases
The present invention relates to methods for efficient and reliable construction of adenovirus vectors which contain and express foreign DNA and are useful for gene transfer into mammalian cells,...
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7132271 |
Methods for enhancing the production of viral vaccines in cell culture
Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral...
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7132106 |
Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a...
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7132277 |
Helper dependent vector system for gene therapy
The present invention features helper-dependent adenoviral vector elements, and helper adenoviral elements, that enhance the production and isolation of helper-dependent adenoviral vectors. Such...
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7132233 |
Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus
West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the...
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7132284 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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