|
Match
|
Document |
Document Title |
|
|
7294500 |
Mosaic infectious bursal disease virus vaccines
The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable...
|
|
|
7294481 |
Method for producing recombinant proteins
A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of...
|
|
|
7291453 |
Viral variants
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the...
|
|
|
7282199 |
Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of...
|
|
|
7279547 |
Insecticidal compounds and methods for selection thereof
A series of potent and highly specific insecticidal toxins characterized by an amino acid sequences SEQ ID NO: 2-35.
|
|
|
7279279 |
Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
This invention provides a method for determining susceptibility for an anti-viral drug comprising: (a) introducing a resistance test vector Comprising a patient-derived segment and an indicator...
|
|
|
7279318 |
Modification of biological elements
A method of modifying the biological and/or physicochemical properties of biological elements such as viruses and other micro-organisms is disclosed in which the biological element is modified by...
|
|
|
7279555 |
Advanced antigen presentation platform
The present invention provides particles for the presentation of haptens for the purpose of eliciting an immune response. The amino acid sequences of the monomers which make up the particles are...
|
|
|
7279565 |
Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
The exposure of cells, tissues and organs to “stress,” such as elevated temperature, stimulates production of active heat stress transcription factors (HSF), which in turn, induce expression of...
|
|
|
7279165 |
Amyloid β1-6 antigen arrays
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
|
|
|
7276333 |
Viral infection inhibitor targeting integrase N-terminal domain
The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a...
|
|
|
7273616 |
Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof
The present invention provides genetically engineered cell lines, recombinant vectors, and vaccines. The present invention also provides methods for generating an in vitro system for Varicella...
|
|
|
7273752 |
Compositions and methods for identifying antigens which elicit an immune response
This invention relates to an expression vector wherein said expression vector comprises a polynucleotide promoter sequence, a polynucleotide encoding a signal sequence, a polynucleotide encoding an...
|
|
|
7270812 |
Pharmaceutical composition for treatment of cancers
The present invention relates to a pharmaceutical composition for treatment of cancers containing Sindbis virus as an active ingredient, a method for treatment of cancers, which comprises...
|
|
|
7267825 |
Parvovirus vectors and their use
This invention relates to a parvovirus vector having a parvovirus DNA excisable from the vector DNA in a parvovirus-permissive cell, the parvovirus DNA having a left terminus which comprises a...
|
|
|
7264811 |
Purified active HCV NS2/3 protease
A method for producing a refolded, inactive form of recombinantly produced NS2/3 protease which comprises the steps of: a) purifying the protease from inclusion bodies in the presence of a...
|
|
|
7264818 |
BAV packaging regions and E1 transcriptional control regions
The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus...
|
|
|
7264923 |
Norovirus infected cell cultures and uses therefor
A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and...
|
|
|
7264957 |
Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV), proteins encoded by the polynucleic acids, vaccines based on the proteins and/or polynucleic acids, a method of protecting a pig from a PRRSV and a method of detecting a PRRSV
The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open...
|
|
|
7262342 |
FUS6 nucleic acid molecules and methods of their use in enhancing disease resistance in plants
The present invention is directed to nucleic acid molecules that encode Fus6 defensive polypeptides and methods of their use in enhancing disease resistance of a plant to a fungal pathogen....
|
|
|
7262274 |
Kits containing rank polypeptides
Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are...
|
|
|
7262045 |
Methods of producing influenza vaccine compositions
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
|
|
|
7257365 |
Serum biomarkers of Hepatitis B Virus infected liver and methods for detection thereof
The invention provides a method for detecting the presence of altered serum proteins in an Hepatitis B Virus (HBV)-infected patient with liver inflammation, comprising: obtaining a sample of serum...
|
|
|
7256005 |
Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
Disclosed are methods for screening that may be used to identify an inhibitor of HCV p7 protein. The methods may include incorporating an HCV p7 protein into a membrane to create an HCV...
|
|
|
7252957 |
Identification of etiology of autism
Disclosed herein is a method for following up a prognosis of children with autism before and after treatment with different modalities administered by their clinicians, confirming the involvement...
|
|
|
7252984 |
Attenuated mutant newcastle disease virus strains for in ovo vaccination, method for preparing and their use
The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains suitable for in ovo vaccination of avian species comprising a mutation in the gene...
|
|
|
7247433 |
Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles
The present invention relates to a method of vaccinating a mammal against papillomavirus by administering papillomavirus virus-like particles transdermally to a mammal under conditions effective to...
|
|
|
7244586 |
DNA molecules encoding ligand-gated ion channels from Drosophila melanogaster
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also...
|
|
|
7244435 |
DNA vaccine expressing HA1 of equine-2 influenza virus
The invention is for a DNA vaccine expressing the hemagglutinin (HA1) gene of equine-2 influenza virus. By engineering a stop codon within HA1, expression of HA1 is ensured. By encapsulation of the...
|
|
|
7244432 |
Infectious bursal disease virus (IBDV) variant from Georgia
A VP2 protein isolated from a variant Georgia strain of Infectious Bursal Disease Virus (IBDV) and method of generating such VP2 protein and variant strain for use to reduce or prevent infection in...
|
|
|
7244434 |
Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing...
|
|
|
7238526 |
Methods and cell line useful for production of recombinant adeno-associated viruses
Methods for efficient production of recombinant AAV employ a host cell which comprising AAV rep and cap genes stably integrated within the cell's chromosomes, wherein the AAV rep and cap genes are...
|
|
|
7235235 |
Alphavirus RNA replicon systems
The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper...
|
|
|
7235394 |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in...
|
|
|
7235392 |
Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
Cell preparations comprising a plurality of apoptotic EBV-transformed B lymphocytes and methods of producing cell preparations comprising a plurality of apoptotic EBV-transformed B lymphocytes. The...
|
|
|
7235391 |
Formulation of adenovirus for gene therapy
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use...
|
|
|
7235393 |
Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
A method for isolating AAV viruses from cellular DNA of non-human primate (NHP) tissues by transfecting the DNA of NHP into 293 cells, rescuing the virus and amplifying it through serial passages...
|
|
|
7232564 |
Methods of polyvalent bacteriophage preparation for the treatment of bacterial infections
The multivalent strains of bacteriophages, methods of obtaining these and their use in the treatment of bacterial infections, particularly those of drug-resistant bacterial strains, especially...
|
|
|
7232680 |
Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a...
|
|
|
7229624 |
Ordered molecular presentation of antigens, method of preparation and use
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
|
|
|
7227010 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain...
|
|
|
7226780 |
Lentivirus vector system
A method is disclosed for improving encapsidation of transgene RNA using retroviral packaging and transfer vectors. An HIV-2 transfer vector, which includes the transgene, is introduced into a...
|
|
|
7226774 |
Signal for packaging of influenza virus vectors
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and...
|
|
|
7223593 |
Herpes virus strains for gene therapy
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a...
|
|
|
7223853 |
Secreted frizzled related protein fragments
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of...
|
|
|
7223585 |
Viral purification methods
The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of...
|
|
|
7223560 |
Non-lytic baculovirus
A baculovirus that infects a host cell without lyzing the host cell and related protein expression method. Within the scope of this invention are in vitro and in vivo methods for detecting protein...
|
|
|
7223584 |
Recombinant rabies vaccine and methods of preparation and use
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of...
|
|
|
7220568 |
Nucleic acids encoding the PRO1561 polypeptide
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7220577 |
Modified AAV
Libraries of modified AAV cap genes are generated by synthesizing modified cap genes using degenerate oligonucleotides. Combinatorial libraries of virions composed of modified (e.g., chimeric),...
|