|
Match
|
Document |
Document Title |
|
|
6596269 |
Methods of treating chronic pain
This invention pertains to the surprising discovery of novel compositions and methods which selectively treat chronic pain while not significantly affecting basal nociceptive, acute pain,...
|
|
|
6596280 |
Method for generating birnavirus from synthetic RNA transcripts
A system for the generation of live Bimavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds) RNA virus of the Bimaviridae family, using synthetic transcripts...
|
|
|
6593111 |
Directional assembly of large viral genomes and chromosomes
Full-length, functionally intact genomes or chromosomes are directionally assembled with partial cDNA or DNA subclones of a genome. This approach facilitates the reconstruction of genomes and...
|
|
|
6592874 |
Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered...
|
|
|
6593123 |
Large-scale recombinant adeno-associated virus (rAAV) production and purification
Methods are provided for large-scale purification of recombinant AAV (rAAV) virions that were produced in the absence of infectious adenovirus. Preferably, the rAAV is produced in a host cell line...
|
|
|
6593134 |
Method of propagating chicken infectious anemia virus
The present invention relates to a method of propagating chicken infectious anemia virus (CIAV). This method involves providing a Marek's disease chicken cell line—CU147 culture and inoculating...
|
|
|
6593141 |
Scorpion toxins
This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or...
|
|
|
6589534 |
Hepatitis B virus binding proteins and uses thereof
An isolated nucleic acid, a recombinant protein encoded thereby and uses thereof. The isolated nucleic acid including (a) a polynucleotide at least 60% identical to SEQ ID NOs:1, 3, 5 or portions...
|
|
|
6589522 |
Vaccines against infections caused by YF virus; YF infectious cDNA, method for producing a recombinant YF virus from the YF infectious cDNA and plasmids to assemble the YF infectious cDNA
The present invention is related to a vaccine composition for humans against YF infections consisting essencially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious...
|
|
|
6586208 |
Use of suppressor tRNA's to regulate cytotoxicity during the production of recombinant gene products
Suppressor tRNA's are used to regulate expression of transgenes that are toxic, or the expression thereof requires a factor that is toxic, to the host cell.
|
|
|
6582693 |
Recombinant MVA virus expressing the E2 gene of Bovine papillomavirus and its use in the therapy of tumors generated by papillomaviruses
A recombinant vaccinia virus derived from the vaccinia virus Ankara (MVA) encoding and capable of expressing the E2 gene of Bovine papillomavirus. Also, the use of the virus in the treatment of...
|
|
|
6582915 |
Production of anti-self bodies from antibody segment repertories and displayed on phage
Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species....
|
|
|
6582947 |
Medical use of gene and vector encoding a multisubstrate deoxyribonucleoside kinase
By inserting a DNA or RNA sequence comprising a subsequence showing a homology of at least 60%, preferably at least 80%, and most preferably at least 90% of the DNA sequence of SEQ. ID. NO. 1 into...
|
|
|
6576456 |
Chimeric adenovirus fiber protein
The invention provides a chimeric adenovirus fiber protein including a nonnative amino acid sequence, and a chimeric adenovirus fiber protein lacking a native amino acid receptor-binding sequence....
|
|
|
6572863 |
Constitutive expression of non-infectious HIV-like particles
Non-infectious, non-replicating immunogenic HIV-like particles are produced by stable long-term constitutive expression in mammalian cells by eliminating elements toxic to the mammalian cells. An...
|
|
|
6573090 |
Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one...
|
|
|
6573041 |
Neuronal cell model and methods of use thereof
We previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells that allows for inducible virus...
|
|
|
6573081 |
Method for growing circoviruses
Methods for growing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are...
|
|
|
6573078 |
Compounds which inhibit HIV replication
This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane...
|
|
|
6569422 |
Genetically engineered cell culture adapted infectious bursal diseases virus (IBDV) mutants
The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284...
|
|
|
6569635 |
Growth state-specific immunofluorescent probes for determining physiological state and method of use
A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody...
|
|
|
6569426 |
Tresyl-monomethoxypolyethylene glycol-modified viruses having viral infectivity
Viruses are modified by coupling a polymer such as polyethylene glycol to obtain polymer-modified viruses that can exhibit reduced antigenicity while retaining infectivity, and which may exhibit...
|
|
|
6569679 |
Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene
The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no...
|
|
|
6566343 |
High affinity nucleic acid ligands of complement system proteins
Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of...
|
|
|
6566513 |
Lentivirus from the group of immunodeficiency viruses of drill monkeys (Mandrillus leucophaeus) and their use
The present invention relates to an immunodeficiency virus of drill monkeys, its RNA, the corresponding cDNA, proteins derived therefrom and fragments of the nucleic acids or proteins. The...
|
|
|
6566117 |
Immortal cell line derived from grouper Epinephelus coioides and its applications therein
The present invention describes (1) an immortal cell line derived from grouper and a method for establishing the cell line; (2) methods for mass producing and purifying aquatic viruses using the...
|
|
|
6566083 |
Method of detecting biologically active substances
The present invention relates to a method of detecting biologically active substances affecting intracellular processes, an isolated DNA, a vector and a cell for use in the method. More...
|
|
|
6562350 |
Combined vaccine against both HAV and measles virus and method of producing it
A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and...
|
|
|
6562376 |
DNA vaccines against poxviruses
In this application is described a poxvirus naked DNA vaccine which protects animals against poxvirus challenge comprising IMV and EEV nucleic acids from poxvirus. Methods of use of the vaccine and...
|
|
|
6558923 |
Rapid single-cycle assay for human immunodeficiency virus type 1 drug resistance
The invention provides an in vitro single cycle, recombinant virus assay (RVA) for determining inhibition of HIV replication by a protease inhibitor. The assay comprises transfecting a human...
|
|
|
6555346 |
Protein expression in baculovirus vector expression systems
The invention relates to a method to increase protein expression in baculo vector virus expression systems. The invention provides a method to produce a recombinant protein in insect-cell culture...
|
|
|
6555672 |
Growth differentiation factor promoter and uses therefor
GDF promoters (e.g., GDF-8 promoters) are described. Also described are methods of using the GDF promoters to regulate tissue-specific gene expression, and to identify compounds which regulate GDF...
|
|
|
6555310 |
Polyclonal libraries
The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display...
|
|
|
6555107 |
Lentiviral nucleic acids and uses thereof
The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are...
|
|
|
6551823 |
EBV-infected stomach cancer cell line
An EBV strain infecting epithelial cells and a stomach cancer cell line cancerated by EBV are established to clarify the mechanism of canceration of epithelial cells into stomach cancer by EBV and...
|
|
|
6548301 |
Retroviral gene transfer vectors
The invention relates to novel retroviral gene transfer vectors, preferably expression vectors, which, because of a reduced content of viral genes, are distinguished by a higher safety standard and...
|
|
|
6544527 |
Non-infectious, immunogenic, human immunodeficiency virus-like particles devoid of long terminal repeats and a functional pol coding region
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product,...
|
|
|
6544731 |
Production of anti-self antibodies from antibody segment repertories and displayed on phage
Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species....
|
|
|
6544770 |
Quantitation of viruses by light scattering
A method for determining the number or concentration of virus particles in a sample by use of a light scattering detector. The method may be used to quantitate purified virus preparations or virus...
|
|
|
6544507 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumor specific transcription factor binding sites in place of one or more wild type transcription factor binding...
|
|
|
6544521 |
Immunoreactive peptide CTL epitopes of human cytomegalovirus pp150
The invention provides peptides which are immunogenic epitopes recognized by CD8 + class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The...
|
|
|
6544769 |
Compostions comprising viruses and methods for concentrating virus preparations
A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from...
|
|
|
6541245 |
Adenoviral helper vectors
The present invention is directed to improved helper vectors and cell lines for the production of pseudoadenoviral (PAV) vectors containing substantially reduced levels of contaminating helper...
|
|
|
6541609 |
HIV-2 peptides
A substantially pure polypeptide having at least one antigenic determinant that is substantially identical to an antigenic determinant of a protein from a cell line infected with simian...
|
|
|
6541223 |
Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and...
|
|
|
6537813 |
Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby
The invention relates generally to methods and apparatuses that are adapted for the preparation of gene therapeutic compositions, as well as the compositions formed thereby. The invention also...
|
|
|
6537555 |
Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA...
|
|
|
6534642 |
Compositions corresponding to a calcium transporter and methods of making and using same
Nucleic-acid and amino-acid sequences correspond to a calcium-transport protein regulating the movement of calcium across cell membranes.
|
|
|
6531307 |
Adenoviral vectors encoding a cytokine and a conditionally lethal gene
The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (eg. HSVTK) that activates a compound with little or no...
|
|
|
6531300 |
Target amplification of nucleic acid with mutant RNA polymerase
This invention provides for a novel amplification procedure for nucleic acid. The method uses a mutant RNA polymerase designed to transcribe deoxynucleotides. Using primers that bind to target...
|