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6669943 |
Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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6664099 |
Method for the preservation of viruses and mycoplasma
A biologically-active material comprising a live virus or mycoplasma is preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose having a residual moisture...
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6663872 |
Hemorrhagic enteritis virus DNA sequences, proteins encoded thereby and various uses thereof
The present invention relates to a DNA sequence comprising a nucleotide sequence encoding Hemorrhagic Enteritis virus. It is well known to the man of the art that determining the complete sequence...
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6660272 |
Porcine circoviruses, vaccines and diagnostic reagents
The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It...
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6660514 |
Method of preparing recombinant adeno-associated virus compositions
Disclosed are methods for the isolation and purification of high-titer recombinant adeno-associated virus (rAAV) compositions. Also disclosed are methods for reducing or eliminating the...
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6660273 |
Chimeric vaccine against tick-borne encephalitis virus
A live, attenuated chimeric virus vaccine against tick-borne encephalitis virus comprising the preM and E structural genes of the tick-borne encephalitis Langat virus and the non-structural genes...
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6656463 |
Compositions and methods for reducing the amount of salmonella in livestock
The invention provides compositions comprising Felix 0-1 Phage (F01 phage) in a an-acceptable carrier and methods of administering the compositions to a livestock animal to reduce or prevent...
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6656719 |
Serum-free, low-protein media for rotavirus vaccine production
Defined serum-free, low protein media (LPKM), that supports 1) Vero cell growth for up to 20 passages, 2) Vero cell growth on microcarriers and 3) rotavirus production is provided. Maximum cell...
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6656720 |
Animal cells and processes for the replication of influenza viruses
Animal cells are described which can be infected by influenza viruses and which are adapted to growth in suspension in serum-free medium. Processes for the replication of influenza viruses in cell...
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6653081 |
Methods for monitoring antiretroviral therapy and guiding therapeutic decision in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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6649396 |
Fiber receptor-independent system for the propagation of adenoviral vectors
The present invention provides a means for the propagation of adenovirus lacking the native tropism by using genetic methods to modify the fiber protein by addition of a C-terminal tag. The...
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6649407 |
Targeting adenovirus with use of constrained peptide motifs
The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a...
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6649373 |
Use of trans-activation and CIS-activation to modulate the persistence of expression of a transgene
Provided are methods of modulating the persistence of the expression in a cell of a transgene, such as a transgene in a non-Herpes vector or in at least E4Δ adenoviral vector, and related systems....
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6642051 |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
High-efficiency AAV packaging constructs and methods for their use are provided. in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1...
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6642042 |
Producing viruses utilizing immortal avian cells
The invention features apoptosis-resistant, non-transformant immortalised avian cells, in particular, avian tissues, i.e., other than blood or haematopoietic cells, particularly fibroblasts and...
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6642052 |
Efficient generation of adenovirus-based libraries by positive selection of adenoviral recombinants through ectopic expression of the adenovirus protease
Disclosed is a new system for generating recombinant adenovirus vectors and adenovirus-based expression libraries, by positive selection of recombinants deleted for the endogenous protease gene,...
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6642207 |
Artificial chromosome constructs containing foreign nucleic acid sequences
The invention provides artificial chromosome constructs containing foreign nucleic acid sequences, such as viral nucleic acid sequences, and methods of using these artificial chromosome constructs...
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6641817 |
Herpes virus vectors for dendritic cells
An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dentrictic...
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6635476 |
Targeted vectors
This invention provides therapeutic and diagnostic agent delivery vehicles, including viral vectors, that are complexed to a targeting moiety by coordinate covalent linkages mediated by a...
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6635244 |
Adenovirus E1B-55K single amino acid mutants and methods of use
Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a...
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6635257 |
Particles of HCV envelope proteins: use for vaccination
The present invention is based on the finding that the envelope proteins of HCV induce a beneficial immune response in chronically HCV-infected chimpanzees. The immunization can preferentially be...
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6635424 |
Method for generating libraries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
A method of producing libraries of genes encoding antigen-combining molecules or antibodies is described. In addition, a method of producing antigen-combining molecules which does not require an in...
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6632670 |
AAV vectors for gene therapy
The present invention is directed to methods for generating high titer, contaminant free, recombinant AAV vectors, methods and genetic constructs for producing recombinant AAV vectors conveniently...
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6632664 |
Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same
An avian infectious recombinant herpesvirus is prepared by inserting a foreign gene, in particular a heterologous antigen gene, into an insertion site in an untranslated genetic region in the...
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6632647 |
Use of strains of parapoxvirus ovis against organ fibrosis
The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with...
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6632438 |
Recombinant poxvirus cytomegalovirus, compositions, and uses
Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the...
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6630348 |
Single-chain insulin analog and a polynucleotide sequence encoding the analog
The subject matter of the invention is directed to a single-chain insulin analog that is used to treat diabetes by gene therapy methods.
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6627617 |
Temperature-sensitive regulation of viral vector production
The present invention provides temperature-sensitive (ts) adeno-associated virus (AAV) Rep78 and Rep68 proteins. In preferred embodiments, the ts AAV Rep78 and Rep68 proteins have missense...
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6627437 |
GBV sequence
Hitherto undiscovered 3′ sequence of GBV confers infectivity in tamarins on otherwise non-infective GBV genome. HCV sequences may be substituted within an infective GBV genome to provide for in...
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6623952 |
Spumavirus isolated from humans
The present invention comprises a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates....
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6623951 |
HBV vectors and cells for producing the same
This invention relates to an HBV vector in which functional genes of HBV are at least partially deleted. In addition, this invention concerns a process for producing such an HBV vector as well as...
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6620914 |
Transcription factor islet-brain 1 (IB1)
The identification and characterisation of human and rat Islet-Brain 1 (IB1) is disclosed, a transcriptional activator that is involved in the control of the GLUT2 and insulin genes by interacting...
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6617128 |
Nucleic acid molecules encoding proteins which impart the adhesion of neisseria cells to human cells
Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid...
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6616931 |
Rotavirus vaccine formulations
The present invention provides liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate...
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6613556 |
Adaptation of virus to vertebrate cells
The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells,...
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6613569 |
Inducible packaging cell lines for lentivirus vectors
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of...
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6613892 |
HSV viral vector
A recombinant herpes simplex virus (HSV) viral vector genome which has substantially lost its transducing properties as a result of a DNA sequence change in the gene coding for Vmw65 protein and...
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6610305 |
Safe attenuated bovine viral diarrhea viruses for use in pregnant cows
This invention relates to the use of specifically attenuated live BVD (bovine viral diarrhea) viruses for the preparation of a vaccine for use in the prevention and/or treatment of BVDV infections...
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6610303 |
Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the...
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6607881 |
Combined ligand and receptor display
A method for selecting nucleic acid sequences encoding ligand and receptor molecules capable of specific binding to each other is disclosed in which nucleic acid encoding ligand or receptor...
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6605460 |
Avian pneumovirus vaccine
Compositions and methods for ameliorating the clinical signs of an avian pneumovirus infection in a bird are disclosed. The compositions include immunologically effective amounts of an attenuated...
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6605281 |
Human papillomavirus vectors for the episomal transduction of host cells and method of making same
A replicon for delivery of a transgene for episomal gene expression in a mammalian host cell includes a transgene having an open reading frame or other nucleic acid sequence for transcription into...
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6605284 |
Gene coding for the measles virus mutant antigen
Disclosed is a measles virus mutant gene coding for a measles virus mutant H protein antigen, wherein said gene coding for a measles virus mutant H protein antigen is at least one member selected...
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6602505 |
Viral chimeras comprised of CAEV and HIV-1 genetic elements
The invention provides a polynucleotide comprising portions of the genomes of caprine arthritis-encephalitis virus and HIV-1, resulting in a chimeric retrovirus referred to as a “CHIV. ” The...
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6599698 |
Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid...
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6599739 |
Infectious papillomavirus pseudoviral particles
The invention provides an infectious papillomavirus pseudoviral particle useful in gene transfer comprising: (a) a papillomavirus vector DNA which comprises an E2 binding site and an expression...
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6599737 |
Adenoviral vectors with tandem fiber proteins
The present invention provides an adenoviral gene transfer vector comprising a first fiber gene and a second fiber gene, wherein the fiber genes are different. The present invention also provides...
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6596269 |
Methods of treating chronic pain
This invention pertains to the surprising discovery of novel compositions and methods which selectively treat chronic pain while not significantly affecting basal nociceptive, acute pain,...
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6596280 |
Method for generating birnavirus from synthetic RNA transcripts
A system for the generation of live Bimavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds) RNA virus of the Bimaviridae family, using synthetic transcripts...
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6593111 |
Directional assembly of large viral genomes and chromosomes
Full-length, functionally intact genomes or chromosomes are directionally assembled with partial cDNA or DNA subclones of a genome. This approach facilitates the reconstruction of genomes and...
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