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9040676 Vigilant cells  
The invention concerns a system for modulating tissue physiology, for example, to prevent or reverse tissue damage caused by disease. The system utilizes vigilant cells that include stable vectors...
9040250 Binding interaction of proanthocyanidins with bacteria and bacterial components  
A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with...
9034343 Attenuated human parainfluenza virus, methods and uses thereof  
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the...
9028834 Pneumovirus compositions and methods for using the same  
Provided are newly identified pneumoviruses that can infect mammals, including dogs cats and potentially humans. Isolated polynucleotides and proteins of the viruses, as well as the isolated...
9028838 Influenza hemagglutinin and neuraminidase variants  
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
9029117 Modified rodent parvovirus capable of propagating and spreading through human gliomas  
Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in...
9029133 Recombinant virus comprising an intact tumor-therapeutic antibody with human constant regions and the use thereof  
The present invention provides a recombinant virus containing a nucleotide sequence encoding a tumor-therapeutic full-length antibody with human constant regions, and uses thereof. After a...
9024001 Alphavirus replicon packaging constructs  
Provided herein are modified, functional 5′ amplification sequences that are defective packaging signals. Also provided are compositions and methods comprising these modified 5′ amplification...
9017694 Swine influenza hemagglutinin variants  
The technology relates in part to modified influenza viruses useful for vaccine development. Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin...
9012224 Chimeric vectors  
The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer...
9011876 Live, attenuated respiratory syncytial virus  
The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The...
8999347 Vaccines for malaria  
The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections,...
8993329 Method of efficiently establishing induced pluripotent stem cells  
Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic...
8992939 Highly efficient influenza matrix (M1) proteins  
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using...
8986707 gM-negative EHV-mutants without heterologous elements  
The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous...
8986987 Herpesvirus of turkeys vectored vaccine against avian influenza in poultry  
The present application applies to the field of veterinary vaccines, in particular of vaccines for poultry against avian influenza. The vaccine is based on a recombinant viral vector expressing...
8986674 Methods and compositions concerning poxviruses and cancer  
The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more...
8986972 Nucleic acid encoding DLL3 antibodies  
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
8986706 Newcastle disease virus vectored herpesvirus vaccines  
The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors encoding and expressing herpesvirus...
8986705 Methods of producing influenza vaccine compositions  
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
8986672 Use of mutant Herpes Simplex Virus-2 for cancer therapy  
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic...
8986709 Vaccine for prophylaxis or treatment of an allergen-driven airway pathology  
The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for...
8981073 Hepatitis C virus gene  
Disclosed are an HCV gene having higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b, an RNA replicon having this gene, a cell infected with this...
8980545 Divergent picornavirus: cosavirus  
Presented herein is the discovery of a new human picornavirus, Cosavirus (previously termed Dekavirus), methods of detecting the Cosavirus and diagnosing Cosavirus infection, methods of treating...
8980610 Arginine inactivation of viruses  
The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic...
8974797 Virus-like particles as vaccines for paramyxovirus  
The invention provides expression vectors and virus-like particles (VLPs) containing Newcastle Disease Virus Sequences in combination with sequences encoding proteins of interest. The vectors are...
8969063 Herpes simplex viruses and methods of viral replication  
A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
8969536 Torque teno virus (TTV) isolates and compositions  
The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of...
8961951 Baculoviruses with enhanced virion production and a method for the production of baculoviruses  
The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a...
8961995 Methods and compositions for alphavirus replicons  
The present invention provides alphavirus replicons and methods of their use in producing heterologous protein.
8962297 Bacteriophage lytic enzymes as alternative antimicrobials  
The present invention relates to isolated Clostridium perfringens bacteriophage lytic enzymes from baccteriophages CP26F and CP39O, and uses in controlling Clostridium perfringens.
8956849 Compositions and methods of enhancing immune responses to Eimeria  
Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40....
8951772 Adenoviruses, nucleic acids coding therefor, and use thereof  
The present invention is related to an adenovirus expressing a first protein which is selected from the group comprising an E1B protein and an E4 protein, prior to a second protein which is...
8951791 System for expression of genes in plants  
The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector,...
8951537 Functional influenza virus-like particles (VLPs)  
The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus...
8951535 Lentiviral vectors containing an MHC class I promoter  
The present invention relates to the insertion of a promoter sequence from an MHC class I gene promoter into a lentiviral vector in order to direct the transcription of a transgene, which...
8945584 Cell culture system of a hepatitis C genotype 3a and 2a chimera  
A robust and genetically stable cell culture system for Hepatitis C Virus (HCV) genotype 3a is provided. A genotype 3a/2a (S52/JFH1) recombinant containing the structural genes (Core, E1, E2), p7...
8945873 Polynucleotides encoding Notch receptor antibodies  
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides...
8945531 Recombinant herpes virus and pharmaceutical composition containing the same  
A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or...
8945547 Notch1 receptor antibodies and methods of treatment  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8945874 Polynucleotides encoding NOTCH1 receptor antibodies  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8945581 Process for producing poxviruses and poxvirus compositions  
The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a...
8940517 Methods for isolating and quantifying antigen from vaccines  
The disclosure relates to the development of improved methods for quantifying antigen in a vaccine composition in the absence of available antigen standards. More specifically, the disclosure...
8932580 Methods for purification of bacterial cells and cell components  
The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
8932604 Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens  
Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of...
8932598 Fusion proteins and methods of use  
Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the...
8927251 Targeting of herpes simplex virus to specific receptors  
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
8921044 DNA polymerase variants with reduced exonuclease activity and uses thereof  
Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single...
8920812 Chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus Gag-based VLPS  
The present invention relates to chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus GAG-based virus-like particles (VLPs). The present invention also includes methods of making and...
8920813 Adenoviral vector-based dengue fever vaccine  
The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon...