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7622293 |
Pseudomonas aeruginosa: bacteriophage and uses thereof
The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Pseudomonas aeruginosa , and methods of using that bacteriophage, and/or progeny or...
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7619060 |
Cytoplasmic polyhedrosis virus protein complex of a polyhedrin and a VP3 polypeptide
It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the...
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7618802 |
Compositions of coronaviruses with a recombination-resistant genome
The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are...
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7611884 |
Toxoplasma gondii nucleic acid molecules
The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such...
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7608449 |
Methods and compositions related to high-titer pseudotyped retroviruses
The present invention concerns the methods and compositions related to pseudotyped viral vectors. Embodiments of the invention include pseudotyping expression cassettes that include nucleic acid...
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7604977 |
Methods and compositions for inhibiting HIV infection
This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to modulate a biological activity...
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7604935 |
Soluble rubella E1 envelope protein variants
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the...
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7601825 |
Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer
A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7601490 |
Development of influenza A antivirals
The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein...
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7598071 |
Infectious clone of human parvovirus B19 and methods
The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in...
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7598070 |
Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and...
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7592433 |
Polynucleotides encoding cyclotide-like structures
The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane,...
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7592170 |
Selective precipitation of viruses using polyectrolytes
The invention provides new methods for purifying and concentrating viruses. The inventors have discovered that high molecular weight proteoglycans present in retroviral stocks are co-concentrated...
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7592169 |
Methods and compositions for treatment and prevention of HSV-2 infections and conditions
Live, attenuated, phenotypically stable HSV-2 viruses and methods of making and using the virus are provided. Live, attenuated HSV-2 viruses are constructed using recombinant techniques and can be...
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7588769 |
Viruses encoding mutant membrane protein
A method to prepare viruses with a mutant membrane protein gene, and viruses obtained by the method, are provided.
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7585667 |
Negative strand RNA virus replicon
The present invention relates to non-cytopathic negative-strand RNA virus replicons, and methods of making and using the replicons and replicon systems.
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7585657 |
Signal for packaging of influenza virus vector
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and...
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7585641 |
Immunoassay and method of use
A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The...
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7582614 |
Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive...
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7582447 |
DNA encoding a testicular carnitine transporter
It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by...
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7582303 |
Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E
The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns...
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7582291 |
Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
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7579142 |
Methods for purification of bacterial cells and components
The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
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7579007 |
Production of “biological carriers” for induction of immune responses and inhibition of viral replication
This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus...
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7575911 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
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7572621 |
Detection, characterization and treatment of viral infection and methods thereof
A method of detecting, characterizing and treating viral infection is provided. In particular, a strategy of molecular mimicry is provided for characterizing viral behavior and/or a predisposition...
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7572620 |
H3 equine influenza A virus
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
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7569383 |
Chimeric flavivirus vectors
The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
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7569340 |
Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof
A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by...
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7566562 |
Culturing circular ssDNA viruses for the production of vaccines
The present invention relates to the use of interferon in the in vitro cultivation of animal circular ssDNA virus such as Porcine Circovirus 2 or human TT virus in an animal cell line. Increased...
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7563881 |
Nucleic acid encoding polypeptide involved in cellular entrance of the PRRS virus
The present invention relates to a new polynucleotide that encodes a polypeptide involved in cellular entrance of PRRSV, to a recombinant vector comprising said polynucleotide, to a cell capable of...
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7563617 |
Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
The invention provides recombinant vectors including adenovirus/adeno-associated virus (Ad/AAV) vectors and mini-adenovirus (mAd) vectors. Further, the invention provides cells containing these...
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7563449 |
Methods for reducing cattle reproductive diseases
The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV)...
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7557199 |
Hepatitis C virus vaccine
The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and...
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7556940 |
Assembly of wild-type and chimeric influenza virus-like particles (VLPs)
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA,...
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7556812 |
Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective...
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7550284 |
Production of vaccines
Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to...
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7550283 |
Bacteriophage for lysis of Methylobacterium and compositions and uses thereof
The invention relates to a novel bacteriophage which is lytic for species of the genus Methylobacterium , Human Blood Bacterium (HBB) or both, and derivatives, progeny and recombinant and mutated...
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7550148 |
Targeting of Herpes simplex virus to specific receptors
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
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7547773 |
Nucleic acid molecules encoding prostate specific antigen oligo epitope peptides
The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific...
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7544788 |
Isolated nucleic acid molecule encoding a neurotrophic growth factor
There is disclosed an isolated nucleic acid molecule encoding a human neurotrophic growth factor designated enovin and having the amino acid sequence illustrated in FIG. 1, 21, 23 or 24 or...
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7544362 |
N protein mutants of porcine reproductive and respiratory syndrome virus
The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified...
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7541038 |
Fusogenic, self-propagating blebs as immunogenic compositions
Self-propagating, fusogenic blebs are produced from cells infected with a population of Venezuelan Equine Encephalitis virus replicon particles (VRP). The self-propagating, fusogenic nature of the...
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7538201 |
Recombinant herpesvirus and uses thereof
A recombinant herpesvirus (excluding infectious laryngotracheitis virus) having a DNA that encodes a polypeptide comprising 429 amino acids at the amino terminal end of a protein encoded by the gB...
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7537924 |
Virus strains
The present invention relates to clinical herpes simplex virus (HSV) isolates with improved oncolytic capabilities as compared to reference laboratory HSV strains. The present invention also...
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7537768 |
Influenza virus vaccine composition and methods of use
The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one...
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7534603 |
Fusion protein delivery system and uses thereof
The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is...
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7534596 |
Method and device for producing vaccine
A method of making a vaccine using animal derived component free (ADCF) cell culture technology, including the steps of attaching ADCF-adapted cells to a microcarrier including an attachment...
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7531342 |
Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences
The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae , of the family Paramyxoviridae . The invention also...
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7531180 |
Chimeric alphavirus replicon particles
Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules...
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