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8173399 |
Method for producing lacto-N-biose I and galacto-N-biose
A method for producing lacto-N-biose I and galacto-N-biose inexpensively and conveniently is provided. The method for producing lacto-N-biose I or galacto-N-biose, characterized in that the method...
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8137946 |
Recombinant GRAS strains expressing thermophilic arabinose isomerase as an active form and method of preparing food grade tagatose by using the same
The present invention relates to a recombinant GRAS (Generally Recognized As Safe) strains expressing thermophilic arabinose isomerase as an active form and method of food grade tagatose by using...
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8124388 |
Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase
Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be...
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8124373 |
Isomaltulose synthases, polynucleotides encoding them and uses therefor
The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose...
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8114974 |
Engineered microorganisms with enhanced fermentation activity
Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.
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8058040 |
Fermentation of pentose sugars
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence...
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8053637 |
Taxus transformation transformed cells, and related compositions and methods
Reported herein are methods for obtaining stably transformed callus in Taxus media ‘Hicksii’, including particularly methods that involve using needles, stem, or bark peel as explant material for...
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8048654 |
Methods and compositions for the recombinant biosynthesis of fatty acids and esters
The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as...
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8048665 |
Nucleotide sequences encoding alanine racemase from coryneform
The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene...
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8043638 |
Mutant ILV5 gene and use thereof
The present invention relates to a mutant acetohydroxy-acid reductoisomerase gene (mutant ILV5 gene) and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior...
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8030051 |
Alanine 2,3-aminomutases and related polynucleotides
The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host...
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8022269 |
Altered metabolism
The present invention relates to methods for increasing the yield of a compound produced by an organism. More particularly, the present invention relates to methods for increasing the total or...
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8012726 |
Method of making bioethanol by using glucose isomerase mutants
This invention provides use of a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity obtained by using recombinant techniques. These...
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8008058 |
Ketose 3-epimerase, its preparation and uses
An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and...
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7998722 |
Zymomonas with improved xylose utilization
Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter...
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7977083 |
Method for microbial production of xylitol from arabinose
Recombinant microorganisms are useful for producing xylitol by fermentation of arabinose. The recombinant microorganisms are produced by transformation of host microorganisms with heterologous...
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7977082 |
Isomaltulose synthases, polynucleotides encoding them and uses therefor
The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose...
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7977077 |
Synthesis of intermediates of oseltamivir carboxylates
Enzymatic pathways for production of aminoshikimate, kanosamine, intermediates, and derivatives thereof; nucleic acid encoding and cells containing the enzymes; compositions containing...
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7939301 |
Enzyme reactions in miniemulsions
The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed...
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7932370 |
Sequence-determined DNA fragments encoding cyclopropyl isomerase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7915025 |
In vivo incorporation of unnatural amino acids
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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7883882 |
Renewable chemical production from novel fatty acid feedstocks
Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as...
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7846707 |
Nucleic acid molecules encoding alanine 2,3-aminomutases
Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate,...
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7829311 |
Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
An acid-resistant peptide solubility tag (an “inclusion body tag”) is provided that is effective in producing peptides of interest in an insoluble form. Fusion peptide constructs comprising the inc...
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7807808 |
Bacteria with increased levels of protein secretion, nucleotide sequences coding for a SecA protein with increased levels of protein secretion, and method for producing proteins
The invention relates to bacteria that have increased levels of protein secretion due to genetic modification, to nucleotide sequences and gene structures containing at least one gene coding for a...
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7792645 |
Three-dimensional structure of chalcone isomerase and methods of use thereof
This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding...
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7732161 |
Production of isoprenoids
The invention provides a biological method of producing isoprenoids.
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7713724 |
Hydantoin racemase
The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least...
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7709235 |
5-Substituted hydantoin racemase, DNA encoding the same, recombinant DNA, transformed cell, and process for production of optically active N-carbamylamino acid or optically active amino acid
Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin...
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7691619 |
Sequence of thermotolerant L-rhamnose isomerase gene and use of the same
The invention relates to an isolated protein including an amino acid sequence represented by SEQ ID NO:2 and having an L-rhamnose isomerase activity. This novel enzyme has a higher reaction...
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7666653 |
Low-substrate-specific amino acid racemase and process for producing racemic amino acid
The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the...
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7622284 |
Transformed eukaryotic cells that directly convert xylose to xylulose
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence...
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7608416 |
Targeting mPGES-1 as a treatment for inflammation which avoids cardiovascular risk
The present invention relates to methods for the treatment of inflammation and pain without increasing cardiovascular risk by administration of an inhibitor of mPGES-1. The invention further is...
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7585656 |
Crystallographic structure of TcPRACA and uses therefor
The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as...
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7582454 |
5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids
The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7501267 |
Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof
In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses...
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7501246 |
Gene for coding thermostable L-arabinose isomerase and method for producing the same
Disclosed are a gene coding for L-arabinose isomerase derived from Thermotoga neapolitana 5068, a thermostable arabinose isomerase expressed from the gene, a recombinant expression vector...
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7456271 |
Glutamate 2,3-aminomutases and methods of use thereof
There are provided nucleic acids, including isolated DNA molecules, which encode glutamate 2,3-aminomutase enzymes, polypeptides produced from such nucleic acids and methods of making the nucleic...
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7452701 |
Methods for the preparation of β-amino acids
Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be p...
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7445915 |
Mutant isopropylmalate isomerase
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate...
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7439050 |
Corynebacterium glutamicum genes encoding diaminopimelate epimerase
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7399626 |
Glucuronyl C5-epimerase, DNA encoding the same and uses thereof
The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to...
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7381544 |
Nucleic acid that encodes a fusion protein
This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a...
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7371555 |
Polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same
The invention relates to isolated polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising t...
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7354745 |
Method for producing L-β-lysine
Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds. Although enantiomerically pure β-amino acids, such as L-β-lysine, can be produced by st...
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7326546 |
Purine-derived substance-producing bacterium and a method for producing purine-derived substance
A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative...
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7309597 |
Alanine 2,3-Aminomutase
Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate,...
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7282359 |
Plant 1-deoxy-D-xylulose 5-phosphate reductoisomerase
This invention relates to an isolated nucleic acid fragment encoding a 1-deoxy-D-xylulose 5-phosphate reductoisomerase. The invention also relates to the construction of a chimeric gene encoding...
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7273755 |
Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds
Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell...
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