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7618940 |
Fat regulation
The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat,...
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7601542 |
Analytical method for protein mapping using hydrogen/deuterium exchange
Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide...
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7598027 |
Botulinum toxin screening assays
Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of...
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7588944 |
Method of analyzing C-terminal amino acid sequence of peptide
An analyte peptide is selectively degraded sequentially by using an alkanoic anhydride (S 101 ). The original peptide and a series of degradation reaction products having peptide in which one or...
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7588910 |
Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor....
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7588906 |
Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules
Polyacrylamide-based methods of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect biomolecules and to measure their...
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7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
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7575888 |
Method of determining chymase activity with secretory leukocyte protease inhibitor
It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of...
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7575887 |
Detection of proteases secreted from pathogenic microorganisms
A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being...
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7572600 |
Enzymatic activities in chemokine-mediated inflammation
Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1...
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7572599 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
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7560258 |
Glass-immobilized, protein-acrylamide copolymer and method of making thereof
Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect proteins and to measure their...
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7556936 |
Exogenous proteases for plant activation of insect toxin
Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic...
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7553632 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
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7531317 |
Fluorescence polarization assay to detect protease cleavage
The invention discloses a method of determining protease activity, in real time, using fluorescence polarization technology. In particular, the invention provides vectors and a method for their...
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7521188 |
Optical monitoring of cleaving enzyme activity
A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the...
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7482136 |
Glycosylation variants of BACE
Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences,...
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7482135 |
Proteolytic enzymes in urine as diagnostic parameters in diseases involving matrix remodelling
A method for determining whether a urine sample has been obtained from a subject suffering from a kidney disorder involving kidney damage. The method is based on determining the level of a...
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7479378 |
Method of analyzing enzyme compositions with lipolytic, proteolytic and amylolytic activity
A method for analyzing the identity, protein and/or peptide pattern and also the stability of samples containing physiologically acceptable enzyme mixtures with lipolytic, proteolytic and...
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7476515 |
Affinity trap reactor and single-step process for purifying angiostatin-like fragment from human plasma using the same
The present invention provides an affinity trap reactor that enables the reaction between an enzyme bound to a support and substrate to proceed efficiently without its applications being restricted...
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7468258 |
Self-quenching homofluorophore compositions for detecting enzyme activity
The inventive subject matter relates to methods, kits, and compositions for detecting enzyme activity in a biological sample. In particular, the inventive subject matter relates to methods, kits,...
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7468257 |
Protein S functional assay
The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma...
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7456007 |
β-secretase enzyme compositions and methods
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of...
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7452690 |
Protease EFC cell surface fusion protein assay
Methods and reagents are provided for measuring protease activity. The reagent comprises a surface to which is linked an enzyme donor fragment through a protease recognition sequence, where the...
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7452683 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
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7449305 |
Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in...
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7439035 |
Method of identifying or characterizing a compound that modulates ribonuclease H activity
The invention relates to a substrate and method for the assay of ribonuclease H activity. The substrate comprises a DNA/RNA heteroduplex molecule having fluorophore and quencher molecules in close...
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7435538 |
High throughput screening method of drug for physiologically active protein
The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use...
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7432070 |
Homogenous assay for enzymatic activity
An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a...
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7432044 |
Methods and compositions for modulating hepatocyte growth factor activation
The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin.
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7429463 |
Method for diagnosing a transmissible spongiform subacute encephalopathy caused by an unconventional transmissible agent strain in a biological sample
The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves...
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7425425 |
Method for the detection of enzyme-catalyzed cleavage reactions by fluorescence spectroscopy
A method involves the detection of enzyme-catalyzed cleavage reactions using modular chemical compounds as substrates for the enzymes involved, and detection is effected by use of...
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7422892 |
Enzyme-based device for environmental monitoring
A sensor for the intermittent or continuous detection of the presence of at least one analyte in an environmental sample includes at least one enzyme that is selected to either (i) catalyze a...
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7422867 |
Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7422866 |
On-line enzymatic digestion in separation-detection methods
Apparatus and methods are disclosed for digesting a biopolymer in a medium. The medium is disposed adjacent a wall of a hollow element wherein at least a portion of the wall is porous. The medium...
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7422865 |
Method of identifying peptides in a proteomic sample
The present invention provides a new and improved method for reducing the complexity of a proteomic sample, and preferably also for allowing identification of proteins in the sample. In one aspect,...
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7416857 |
Differential diagnosis with hepcidin
The present invention concerns the use of hepcidin as a marker for detecting inflammatory chronic diseases and especially for a differential diagnosis to detect inflammatory chronic diseases and/or...
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7416854 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
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7410774 |
Compounds modulating sister chromatid separation and method for identifying same
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity....
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7402407 |
Chemically targeted positional identification of post-translationally phosphorylated peptides
Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in...
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7399607 |
Fluorescence polarization assays for determining clostridial toxin activity
The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease...
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7396649 |
Migraine and vasodilation treatment
The present invention related to the use of Cystatin in predicting onset of migraines. The invention also relates to the use of Cystatin as a vasodilatory agent. The invention also relates to...
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7393659 |
Analytical method for the determination of infant formula protein digestibility in vitro
A method for in vitro determination of the digestibility of proteins in a nutritional product. The method utilized gastric and intestinal enzymes that are standardized for in vitro digestion...
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7384790 |
Method of analyzing peptide for determining C-terminal amino acid sequence
The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by applying reaction technique for successively releasing the C-terminal amino acids therefrom,...
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7384758 |
Bioluminescent protease assay with modified aminoluciferin or derivatives thereof
A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay...
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7381538 |
Optical biosensor with enhanced activity retention for detection of halogenated organic compounds
A distal tip, and associated method of producing, of a biosensor ion sensing transducer for use in detecting an analyte comprising an halogenated organic compound in an environment such as soil or...
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7374896 |
GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an...
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7361485 |
Method for the detection of proteolytic enzymes
The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase...
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7361335 |
Methods for using an elastase
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
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7358088 |
Peptides and compositions which modulate apoptosis
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions...
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