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8163278 |
Methods for treating pervasive development disorders
A method of determining the efficacy of secretin, neuropeptides, peptides, and/or digestive enzymes for treatment of an individual diagnosed with a pervasive development disorder, such as autism,...
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8137926 |
Kit for assaying EphA4 processing by gamma-secretase
The present invention provides a kit for assaying the processing of EphA4 by γ-secretase.
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8129135 |
Method for diagnosing cardiovascular diseases
Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof...
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8124737 |
Stabilized preparations of serine endopeptidases, their preparation and use
The invention relates to stabilized preparations of serine endopeptidases which are suitable for use as a test reagent in a diagnostic procedure or for a therapeutic use. As a result of the...
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8124371 |
Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation
The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for...
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8124370 |
Cationic anti-microbial peptides and methods of use thereof
Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a...
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8124357 |
Lipophilic dye-based fret assays for clostridal toxin activity
Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance...
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8119411 |
Method for analyzing C-terminal amino acid sequence of peptide using mass spectrometry
The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by using a reaction for successively releasing the C-terminal amino acids of the peptide, which...
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8105800 |
Composition for assaying glycated proteins
Composition for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino...
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8105584 |
Method for treating pervasive development disorders
A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and...
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8101376 |
Swatch for testing the washing performance of an enzyme
The present invention relates to a swatch comprising a pH-indicator substance and a substrate for an enzyme for testing the washing performance of the enzyme, e.g. an enzyme for use in detergent...
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8080423 |
Reagent containing protease reaction promoter and/or colorant stabilizer
Stabilizers for colorants used for detection of enzymatic reactions, having a cyclodextrin and a catalase; reagents including stabilizers; and methods of use of such stabilizers and reagents.
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8076099 |
Biomarkers of Francisella infection
The instant invention concerns Francisella bacteria mediated degradation of alkaline phosphatase (AP). Detection of AP degradation may be used to determine the presence of Francisella bacteria in a...
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8071328 |
Bioluminescent protease assay
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
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8067238 |
Use of acid stable protease in animal feed
The present invention relates to acid-stable proteases homologous to those derived from strains of the genus Nocardiopsis, their use in animal feed, feed-additives and feed compositions containing...
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8066991 |
Enzyme inhibitors of PAI-1
The invention provides a method for the treatment of a subject suffering from a cardiovascular disease using a therapeutically effective amount of at least one enzyme that is capable of inhibiting...
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8058024 |
Devices for the detection of the presence and/or activity of proteases in biological samples
The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
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8058409 |
Method of serum pre-treatment for glycomic analysis
A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention. A salt of the general formula (I): wherein Z, X, R1, R2, M, m and n are the same as described...
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8053208 |
FRET protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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8053209 |
FRET protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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8048643 |
FRET protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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8039228 |
Signal amplification using a synthetic zymogen
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a...
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8029764 |
Methods for detection of colorectal cancer
Particular genes are aberrantly and consistently expressed in both adenomas and carcinomas of the colon. Products of such genes provide stool and serum markers for colorectal neoplasia. One...
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8030084 |
Thyroglobulin quantitation by mass spectrometry
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in...
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8026078 |
Method of quantifying glycosylated protein using redox reaction and quantification kit
The present invention provides a method of measuring a glycated protein in a sample using a redox reaction, by which the glycated protein can be measured accurately with high sensitivity. In order...
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8021855 |
Method of decomposing protein with sulfonic acid compound
A method of assaying a glycated protein in a sample with the use of redox reaction, in which highly reliable measurement can be obtained. A sample containing a glycated protein is treated with...
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8022172 |
Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
Clostridial toxin substrates comprising a lanthanide donor complex, an acceptor, and a Clostridial toxin recognition sequence including a cleavage site; methods for determining the activity of a...
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8012708 |
Method for determination of allergen in environment and kit for simple quantification of allergen
A simple method for measuring allergens is disclosed, by which the amount of environmental allergens can be measured simply without using an anti-allergen antibody. In the method for measuring an...
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8012709 |
Method for determining if a subject having type II diabetes has a kidney disorder
The present invention relates to a method for determining if a subject having Type II diabetes has a kidney disorder by measuring the level of matrix metalloproteinase 8 (MMP-8) in the urine of a...
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8013113 |
FRET protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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8012693 |
Analysis of chemically crosslinked cellular samples
A method of analyzing cellular samples that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry.
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8012710 |
Methods of treating and diagnosing Parkinsons disease and related dysautonomic disorders
A method for treating a Parkinson's patient with digestive/pancreatic enzymes involves administering an effective amount of digestive/pancreatic enzymes to an individual having the disorder in...
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8008085 |
Method of measuring HbA1c
A method of measuring HbA1c is provided that, even with a whole blood sample after storage, measurement accuracy substantially equal to a whole blood sample right after collection can be...
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8008036 |
Method for identifying autistic individuals amenable to digestive enzyme therapy
A method for confirming a diagnosis of autism in an individual comprises obtaining a sample of feces from an individual, determining a quantitative level of chymotrypsin present in the sample, and...
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8003753 |
Fret protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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7998697 |
Endotoxin analysis
The present invention relates to a method for detecting the presence or non-presence of an endotoxin, characterized in that an OmpT protein is brought into contact with a sample suspected of...
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7998749 |
Assays of molecular or subcellular interactivity using depolarization after resonance transfer energy (DARET)
The present invention provides a method of determining the proximity, or changes in the proximity of two or more molecular features labeled with fluorophores able to undergo DARET. In preferred...
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7989215 |
Methods and systems for adding a reagent to an analyte in a gel
The present invention relates to methods and systems for adding a reagent to an analyte in a gel. The invention further provides methods and systems for transferring liquid analyte reagent mixtures...
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7985563 |
HIFαprolyl hydroxylation assay
The present invention provides methods of identifying compounds that decrease proline hydroxylation of the alpha subunit of hypoxia inducible factor (HIFα).
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7968318 |
Process for conversion of granular starch to ethanol
A method is disclosed for producing glucose from a granular starch substrate including, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a...
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7960179 |
Analytical method for protein mapping using hydrogen/deuterium exchange
Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide...
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7956167 |
Purification of collagenases from clostridium histolyticum liquid culture
The present invention provides a method for purifying Clostridium histolyticum collagenase type I and type II proteins from a complex mixture by subsequently performing a precipitation with...
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7951553 |
Method of assaying glycated protein
The present invention provides a convenient, efficient method for assaying glycated protein, fructosyl peptide, or fructosyl amino acid which can be performed with reduced effect of fructosyl...
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7943337 |
Method for screening a protease
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. ...
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7943333 |
Diagnostic method for identifying carriers of the Marburg I variant of factor VII-activating protease (FSAP) on the basis of differential modulation of FSAP activity
The present invention relates to a diagnostic method for identifying persons with genetically related hetero- or homozygous expression of the MR I variant of factor VII-activating protease (FSAP)....
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7939291 |
Methods for the detection of microbial contaminants
The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the...
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7932050 |
Enzymatic substrates derived from phenoxazinone and their use as developers in detection of microorganisms with peptidase activity
Enzymatic phenoxazinone substrates of formula (I): in reaction media containing the same are used for detecting, identifying and/or quantifying microorganisms expressing at least one peptidase...
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7927871 |
Visualization and quantitation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers
This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that...
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7923219 |
Ubiquitin E3 ligase
The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further...
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7919264 |
Methods and compositions for determining the efficacy of a treatment for ankylosing spondylitis using biomarkers
The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a c...
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