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8124396 |
Asparaginases and method of preparing a heat-treated product
The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of...
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8105815 |
Asparaginase and its use in food production
Process for the production of a food product involving at least one heating step, comprising adding one or more enzymes to an intermediate form of said food product in said production process...
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7871806 |
Asparaginases
The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The...
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7829320 |
Asparaginases
The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The...
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7807436 |
Recombinant host for producing L-asparaginase II
The invention provides a recombinant Escherichia coli host cell for producing an Escherichia coli-asparaginase II enzyme. The host cell includes an Escherichia coli chromosome and at least one copy...
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7666652 |
Asparaginases
The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The...
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7396670 |
Asparaginases and method of preparing a heat-treated product
The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of...
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6991788 |
Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence
Described herein are methods for producing recombinant forms of asparaginase derived from Wolinella succinogenes. In addition, methods for covalent modification of proteins, including...
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6955907 |
Alkaline, protease VapK suitable for laundry detergent, VapK gene, recombinant expression vector, and transformed microorganisms
A novel alkaline protease VapK suitable for a laundry detergent is disclosed. The gene vapk coding for the protease VapK, the recombinant plasmids containing said gene, and the transformed V....
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6852834 |
Fusion peptides isolatable by phase transition
Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a...
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6537547 |
Polypeptides having L-asparaginase activity
Disclosed are polypeptides which originate from mammal, having L-asparaginase activity. The polypeptides are easily prepared by applying recombinant DNA techniques to DNAs encoding the polypeptides...
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6274367 |
DNA coding for mammalian L-asparaginase
Disclosed is a DNA coding for mammalian L-asparaginase. Transformants introduced with the DNA effectively produce desired amounts of mammalian L-asparaginase such as those from humans, guinea pigs,...
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5439812 |
Antibodies catalyzing deamidation of proteins
A hapten is described which may be used to elicit antibodies that catalyze the deamidation of asparginyl-glycyl dipeptides to form two products, the isoaspartyl-glycyl dipeptide and the...
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5310670 |
Method for the purification of Erwinia L-asparaginase
A process is provided for the purification of L-asparaginase by contacting a crude extract of L-asparaginase with a solid medium having cation exchange groups so as to adsorb L-asparaginase on the...
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5268271 |
Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
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5177004 |
Enzymatic deacylation of acyl-aminosorboses
The present invention relates to an improved process for the preparation of 1-desoxynojirimycin. 1-Desoxynojirimycin can be reacted by alkylation on the nitrogen atom to give various saccharase...
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4738925 |
Method of increasing solubility of enzymes
A method is provided for increasing the solubility of an enzyme in an aqueous solution comprising providing a water-soluble anionic surfactant to the solution and further providing the solution...
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4729957 |
Process for manufacture of L-asparaginase from erwinia chrysanthemi
A process for the recovery and purification of L-asparaginase from Erwinia chrysanthemi is disclosed. The process involves the preparation of cellular acetone powder extract followed by either an...
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4617271 |
Process for producing immobilized L-asparaginase preparations for the therapy of leukemia
This invention relates to a process for producing immobilized L-asparaginase preparations. Its principal object is to produce immobilized L-asparaginase preparations which are excellent in...
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4500288 |
Angular mold for dental use
The mold in question includes a cap (1) of transparent material strengthened by a single or multiple reinforcement (2, 2', 3) of wire or metal strip incorporated in the plastic of the cap. The cap...
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4473646 |
Stereospecific asparaginases
There is described a method of separating an asparaginase rich fraction from a thermophilic microoganism and then to divide this fraction into its D- and L-asparaginases. Substantially pure...
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4438198 |
Biochemically active matrix for use in a bio-artificial organ
A biochemically active matrix for use in a bio-artificial organ is disclosed. The biochemically active matrix has an enzyme covalently bonded to a matrix of organochemically cross-linked fibrin....
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3897309 |
Process for removing pyrogenic material from aqueous solutions
Trace amounts of pyrogens are removed from aqueous solutions by passing a strongly ionic solution thereof through a column of a basic anion exchange resin.
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3773624 |
PROCESS FOR THE ENRICHMENT OF L-ASPARAGINASE
Crude aqueous solutions of L-asparaginase are purified by fractional precipitation after addition thereto of an aqueous solution of a polyalkylene glycol such as polyethylene glycol, preferably of...
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3669842 |
PURIFICATION OF L-ASPARAGINASE
The present disclosure is directed to a process for purifying an enzyme preparation of L-asparaginase obtained from an L-asparaginase-producing microorganism belonging to the genus Serratia,...
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3664926 |
CRYSTALLIZATION OF L-ASPARAGINASE
L-asparaginase is obtained in crystalline form from aqueous solutions thereof by the use of a water miscible, polar organic solvent and pH control.
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3660238 |
EXTRACTION OF ASPARAGINASE FROM BACTERIAL CULTURE
The enzyme L-asparaginase, used in the treatment of leukemia and disseminated cancer, is extracted in high yield by treating L-asparaginase producing bacteria with strong alkali to release the...
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3655514 |
PROCESS FOR PURIFYING L-ASPARAGINASE
In a process for purifying an enzymatic preparation of L-asparaginase obtained from an L-asparaginase-producing micro-organism belonging to the genus Serratia wherein said micro-organism produces,...
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3652402 |
ASPARAGINASE HAVING ANTI-TUMOR ACTIVITY AND PROCESS FOR PREPARING THE SAME
Process for preparing asparaginase having a strong anti-tumor activity which comprises cultivating an asparaginase-producing micro-organism belonging to Achromobacter, Alcaligenes, Micrococcus,...
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3650902 |
PROCESS FOR THE STABILIZATION AND PURIFICATION OF L-ASPARAGINASE
L-asparaginase is obtained in a highly purified, pyrogen free and stabilized form from a crude aqueous solution thereof, by adding to said solution an amino acid, such as glycine, adjusting the pH...
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3637462 |
PURIFICATION OF ENZYMES
A therapeutic enzyme such as L-Asparaginase is purified from a protein mixture containing the L-Asparaginase by adding a controlled amount of a buffer solution which will solubilize a major portion...
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3634196 |
PROCESS FOR THE SEPARATION OF PYROGENS FROM CRUDE PREPARATIONS OF L-ASPARAGINASE
Crude L-asparaginase is freed of pyrogens by contacting solutions of the same containing weak buffers with diethylaminoethyl dextran gels. The process can be carried out according to batch...
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3627639 |
PROCESS FOR PRODUCING L-ASPARAGINASE
Improved yields of L-asparaginase are produced by culturing a micro-organism belonging to the genus Serratia under aerobic conditions in an aqueous nutrient medium in which the amount of ammonia...
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3622461 |
PROCESS FOR THE EXTRACTION OF L-ASPARAGINASE
From a culture of E. coli the bacterial mass is flocculated by addition of an organic base or a salt thereof having an amino function and a molecular weight above 1,000. The flocculated cells are...
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3620926 |
PROCESS FOR THE ENRICHMENT OF L-ASPARAGINASE
L-asparaginase is obtained in concentrated purified form by fractional precipitation of an aqueous solution thereof with low molecular weight solvents, specifically diols of 4 to 8 carbon atoms,...
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3620925 |
PROCESS FOR PURIFYING L-ASPARAGINASE
The antitumor activity of L-asparaginase produced from the cultured cells of micro-organisms belonging to the genus Serratia is retained by a purification process wherein, as one of the steps in...
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3616230 |
METHOD FOR PRODUCTION OF L-ASPARAGINASE
A method of producing L-Asparaginase from a microbial organism, such as Escherichia coli, which encompasses the use of a nutrient medium for growth of the microbial organism which contains a...
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3607654 |
PROCESS FOR PRODUCING PURIFIED L-ASPARAGINASE
The antitumor activity of L-asparaginase produced from the cultured cells of micro-organisms belonging to the genus Serratia is retained by a purification process wherein the substrate,...
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3542647 |
METHOD FOR PRODUCING L-ASPARAGINASE
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3528887 |
SYNTHESIS OF L-ASPARAGINASE
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3511755 |
SYNTHESIS OF L-ASPARAGINASE
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3511754 |
PROCESS FOR ISOLATING L-ASPARAGINASE
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3783102 |
PRODUCTION OF L-ASPARAGINASE
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3843445 |
ASPARAGINASE PRODUCTION
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3594281 |
CRYSTALLINE COMBINATION OF L-ASPARAGINASE AND A METAL OR METALLOID AND METHOD OF ITS MANUFACTURE
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3684659 |
PROCESS FOR THE ENRICHMENT AND PURIFICATION OF L-ASPARAGINASE
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3741872 |
PROCESS FOR PURIFYING ENZYMES OF THE ASPARAGINASE-TYPE
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3594282 |
PROCESS FOR PURIFYING L-ASPARAGINASE
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3597323 |
METHOD OF PURIFYING L-ASPARAGINASE
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3721606 |
GLUTAMINASE GA
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