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7608445 |
Nitrilases, nucleic acids encoding them and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7595178 |
Process for the preparation of amides
A novel biotechnological process for the preparation of nitrites, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for...
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7556955 |
Nucleic acids encoding Candida kefyr cytosine deaminase
A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the ...
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7556956 |
Enzymes for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for...
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7521216 |
Nitrilases and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7507552 |
Crystallization of histone deacetylase 2
Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
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7507573 |
Modification of protein glycosylation in methylotrophic yeast
The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to...
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7501273 |
Peptidylarginine deiminase 6
A nucleotide acid sequence is provided encoding a peptidylargine deiminase 6. The gene is found to be expressed in gonads only and may be used as target for male and female contraception. Its...
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7462477 |
Protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof
A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes , or a new bacterium ...
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7445923 |
Crystallization and structure of a plant peptide deformylase
This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.
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7432086 |
L-amino acid amide asymmetric hydrolase and DNA encoding the same
A recombinant microorganism is produced by introducing a DNA encoding an enzyme which hydrolyzes an amido bond of L-amino acid amide, especially L-2-alkylcysteine amide, and L-amino acid is...
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7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
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7387893 |
Vectors, cells and processes for pyrimidine deoxyribonucleosides production
Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and...
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7361507 |
Method for modulating nitrilase selectivity, nitrilases obtained by said method and use thereof
The invention concerns a modified nitrilase with modulated selectivity, characterized in that it comprises in position 162 an amino acid residue different from the original amino acid residue.
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7358071 |
Production of 3-hydroxycarboxylic acid using nitrilase mutants
This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidovorax facilis 72W (ATCC...
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7348173 |
Fatty-acid amide hydrolase
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of...
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7282356 |
D-aminoacylase mutants
The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the...
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7264956 |
Compounds and methods for inhibiting axillary malodour
Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having the general formula (I)
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7264800 |
Method and composition for inhibiting cancer cell growth
Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose...
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7241602 |
Nucleic acid sequences encoding enantioselective amidases
The invention relates to nucleic acid sequence encoding enantioselective amides with an amino acid sequence of SEQ ID NO: 2. The invention also relates to a process for fermentation, comprising a...
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7205140 |
Nucleotide sequence for creatinine deiminase and method of use
The present invention relates to the discovery of novel genes encoding a polypeptide having creatinine deiminase activity and methods of use. Also disclosed is a kit using the novel sequences for...
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7198926 |
Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to...
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7186540 |
Thermostable glutaminase and thermostable glutaminase gene
A completely novel glutaminase is provided: (a) a protein consisting of an amino acid sequence represented by SEQ ID NO: 2, or (b) a protein consisting of an amino acid sequence derived from the...
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7169596 |
Adenosine deaminase homolog
This invention provides a novel isolated polynucleotide sequence, called ADARP1 (adenosine deaminase related protein 1), that displays significant homology to the adenosine deaminase (ADA) gene....
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7148051 |
Production of 3-hydroxycarboxylic acid using nitrilase
This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidovorax facilis 72W (ATCC...
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7141404 |
Candida kefyr cytosine deaminase
A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the ...
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RE39352 |
Creatine amidinohydrolase, production thereof and use thereof
A creatine amidinohydrolase having the following physicochemical properties:
Action: catalyzing the following reaction;
creatine+H 2 O→sarcosine+urea
Optimum...
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7098019 |
DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids
DNA for encoding a protein having D-hydantoinase activity which has a base sequence represented by Sequence ID No. 1 in the Sequence Listing. DNA for encoding a protein having D-carbamylase...
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7083966 |
Cytidine deaminase
Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase) are described. The AID proteins are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine...
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7049117 |
Mutant possessing uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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6958231 |
Variants of Erwinia-type creatinase
The present invention relates to mutated genes encoding variants of an Erwinia -type creatinase (EC 3.5.3.3, alternative name: creatine amidinohydrolase), to the creatinase variants encoded by...
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6943004 |
Transformed microorganism and process for producing D-aminoacylase
A transformed microorganism prepared by inserting into a host microorganism with zinc tolerance a D-aminoacylase-producing gene which selectively produces D-aminoacylase alone between...
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6936438 |
Method of producing a polypeptide using oxaloacetate hydrolase deficient fungal host cells
The present invention relates to methods of producing a polypeptide comprising culturing a mutant of a parent cell, wherein the mutant produces less oxaloacetate hydrolase than the parent cell,...
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6919195 |
Glutaminase, glutaminase gene, novel recombinant DNA, and process for manufacturing glutaminase
Glutaminase which comprises (a) a protein comprising an amino acid sequence shown in SEQ ID NO: 2, or (b) a protein which comprises an amino acid sequence having deletion, substitution, or addition...
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6905861 |
D-aminoacylases, method for producing the same, and method for producing D-amino acids using the same
D-aminoacylase derived from fungi is provided. The fungi capable of producing D-aminoacylase include those belonging to the genus Hypomyces, Fusarium, Auricularia, Pythium, and Menisporopsis. The...
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6902915 |
Heat-stable D-aminoacylase
The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded...
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6887697 |
D-aminoacylase and gene encoding the same
The present invention provides the D-aminoacylase-encoding gene derived from Hypomyces mycophilus , a filamentous fungus, the polypeptide encoded by the gene, and the homologues thereof. The...
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6881565 |
Protein having glutaminase activity and gene encoding the same
There are disclosed a protein having an amino acid sequence shown in SEQ ID NO:2, or a protein having a glutaminase activity in which one or more amino acids is/are deleted from, substituted by,...
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6869788 |
DNA encoding novel D-aminoacylase and process for producing D-amino acid by using the same
This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high...
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6869783 |
Method for producing chiral carboxylic acids from nitriles with the assistance of a nitrilase or microoganisms which contain a gene for the nitrilase
The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising...
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6864080 |
Crystallization and structure of Staphylococcus aureus peptide deformylase
Staphylococcus aureus peptide deformylase has been crystallized, and the three-dimensional x-ray crystal structure has been solved to 1.9 Å resolution. The x-ray crystal structure is useful for...
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6852834 |
Fusion peptides isolatable by phase transition
Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a...
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6849432 |
Process for producing amide compounds
The invention is a process for continuously producing an amide compound by reacting a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body...
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6830919 |
Ceramidase gene
A neutral/alkaline ceramidase derived from a mammal; an antibody specifically binding thereto; a probe and primer which are capable of specifically hybridizing thereto; a method for producing the...
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6821766 |
Thermostable creatine amidinohydrolase and process for producing the same
The present invention relates to a thermostable creatine amidinohydrolase having the following physicochemical properties: (a) hydrolyzing 1 mol of creatine to give 1 mol of sarcosine and 1 mol of...
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6780635 |
Process for the preparation of optically active azabicyclo heptanone derivatives
The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single...
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6780634 |
Method for producing (1R,4S)-2-azabicyclo&lsqb 2.2.1&rsqb -hept-5-en-3-on derivatives
A biotechnological method is described for preparing compounds of the general formulas wherein R 1 is acyl or acyloxy and R 2 is a hydrogen atom or C 1-10 alkyl, comprising the conversion of...
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6709851 |
Stabilization of helicobacter urease
The invention provides methods for stabilizing recombinant Helicobacter urease by genetically modifying a urease amino acid. The stabilized urease is prevented from the molecular aggregation or...
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6706513 |
Adenosine deaminase homolog
This invention provides a novel isolated polynucleotide sequence, called ADARP1 (adenosine deaminase related protein 1), that displays significant homology to the adenosine deaminase (ADA) gene....
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6699682 |
Assay for inhibitors of fatty-acid amide hydrolase
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of...
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