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7604980 |
Protein expression system
The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for...
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7595183 |
Cathepsins L-like cysteine protease derived from northern shrimp (Pandalus eous)
The object of the present invention is to find and produce cathepsin L having high activity under neutral to alkaline conditions and at a low temperature range. The present inventors succeeded in...
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7588927 |
Composition and methods relating to SENP1—a sentrin-specific protease
The invention relates to a novel protease, called SENP1, which is active against sentrin-modified proteins in vivo. The invention more specifically relates to the genomic and amino acid sequences...
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7582465 |
Beta secretase genes
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7579180 |
Beta secretase polypeptides
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7572619 |
Recombinant blood clotting factors
The present invention relates to an improved method for the production of recombinant human blood clotting factors, in particular of factor VIII and factor IX. An immortalized human cell line can...
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7560107 |
Modified factor VIII
Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of hemophiliacs,...
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7557079 |
Metalloprotease proteins
This invention relates to proteins termed INSP005 a and INSP005 b , herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and...
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7556936 |
Exogenous proteases for plant activation of insect toxin
Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic...
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7507403 |
Kallikrein gene
The invention relates to a kallikrein protein, compositions comprising the protein, and the use thereof.
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7501117 |
Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes...
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7482148 |
Recombinant calf-chymosin and a process for producing the same
The present invention relates to a recombinant calf-Chymosin protein as set forth in SEQ ID No. 1; a recombinant calf-Chymosin gene as set forth in SEQ ID No. 2 encoding the protein comprising...
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7482136 |
Glycosylation variants of BACE
Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences,...
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7473544 |
Alkaline protease
The present invention provides an alkaline protease exhibiting high detergency and productivity, which is obtained by further enhancing the detergency of an alkaline protease effective against...
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7456269 |
Alzheimer's disease secretase, APP substrates thereof, and uses thereof
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell...
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7456007 |
β-secretase enzyme compositions and methods
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of...
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7452708 |
Human PRSS11-like S2 serine protease and uses thereof
A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout...
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7416869 |
Enzyme delivery systems, application in water based products
Aqueous enzyme delivery systems as well as aqueous cosmetics and personal care products were provided which comprise at least one stabile enzyme and a polyglycerol containing at least 15 carbons....
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7410774 |
Compounds modulating sister chromatid separation and method for identifying same
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity....
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7407933 |
Drug containing angiotensin convertase
The medicine containing angiotensin-converting enzyme or its peptidase-inactivated mutants that specifically releasing GPI-anchored proteins from the cell surface, for preventing or curing...
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7399466 |
Method and compositions for promoting osteogenesis
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require...
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7399465 |
Pharmaceutical compositions for treating arthritis and inflammatory disease
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
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7374933 |
Human metalloprotease and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications.
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7374923 |
Polypeptide
A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide,...
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7364892 |
Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same
The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, 193, 198, 201, 218, 223,...
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7335758 |
Catalytic domain of ADAM33 and methods of use thereof
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the...
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7335504 |
Engineered enzymes and uses thereof
The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for...
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7329529 |
Ubiqutin proteases
The invention provides isolated nucleic acids molecules that encode novel ubiquitin protease polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression...
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7319016 |
Crystallization of cathepsin S
Provided are crystals relating to Cathepsin S and its various uses.
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7314745 |
Protein and DNA encoding the same
An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the...
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7314730 |
Regulation of human transmembrane serine protease
Reagents that regulate human transmembrane serine protease activity and reagents that bind to human transmembrane serine protease gene products can be used to regulate extracellular matrix...
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7312045 |
Aggrecanase-1 and -2 peptide substrates and methods
The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using...
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7311908 |
Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the...
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7291495 |
β-Secretase variant
The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to...
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7282579 |
Serine protease BSSP6
There are provided a polynucleotide encoding human BSSP6 serine protease and a vector and transformed host cells containing this human BSSP6 serine protease encoding polynucleotide.
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7276605 |
Method for producing recombinant trypsin
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH...
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7276365 |
Dipeptidyl peptidases
Peptides including HisGlyTrpSerTyrGlyGlyPheLeu; LeuAspGluAsnValHisPhePhe; GluArgHisSerIle Arg and PheValIleGlnGluGluPhe which show peptidase ability and have substrate specificity for at least one...
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7276349 |
Beta-secretase enzyme compositions and methods
Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in...
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7273743 |
Modified BACE
The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at...
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7270989 |
Method of producing non-bovine chymosin and use hereof
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species,...
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7252820 |
Highly purified mocarhagin, a cobra venom protease, polynucleotides encoding same and related proteases, and therapeutic uses thereof
Methods and compositions for treating a wide range of inflammatory diseases and disorders, and for inhibiting selectin-mediated binding by administering a mocarhagin protein, or fragments thereof...
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7247704 |
Multifunctional protease inhibitors and their use in treatment of disease
Fusion proteins of protease inhibitors are provided, in particular fusion proteins of alpha 1-antitrypsin (AAT) and a second protease inhibitor, such as secretory leukocyte protease inhibitor...
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7235638 |
Coagulation factor VII derivatives
The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells...
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7226999 |
Protein C or activated protein C-like molecules
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention...
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7223858 |
Truncated aggrecanase molecules
Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to...
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7223583 |
Antithrombotic thrombin variants
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
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7217556 |
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE...
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7217555 |
Cloning and characterisation of novel mammalian peptidase
There is disclosed a cDNA molecule encoding human NAALAD-ases designated herein as L, II and IV and having the amino acid sequences illustrated in FIGS. 1, 3, 4 and 5 . The NAALAD-ases...
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7211425 |
Serine protease BSSP4
There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20; proteins having amino acid sequences derived from these amino acid...
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7211424 |
Mammalian Subtilisin/kexin isozyme SKI-1: a proprotein convertase with a unique cleavage specificity
Using RT-PCR and degenerate oligonucleotides derived from the active site residues of subtilisin-kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral...
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