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6426199 |
DNA
Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized...
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6423526 |
Human serine protease
Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These...
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6420157 |
Zymogen activation system
We describe the DNA sequences encoding an expression vector system that will permit, through limited proteolysis, the activation of expressed zymogen precursor of (S1) serine proteases in a highly...
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6413737 |
Ecarin prothrombin protease and methods
New forms of ecarin, a procoagulant protein from Echis carinatus venom, are described, as are polynucleotides encoding the new proteins, methods for production of the new proteins, and methods...
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6410704 |
Methods and compositions for the preparation and use of a herpes protease
The present invention relates to the identification and purification of a herpes protease and a nucleic acid segment coding for two proteins. The first protein is the herpes protease which is able...
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6410272 |
Production of thrombin inhibitors
A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a...
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6406901 |
TNF-a converting enzyme
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of...
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6399349 |
Human aminopeptidase P gene
Disclosed are the human aminopeptidase P cDNA and genomic DNA. Also disclosed is the human aminopeptidase P protein and antibodies reactive with human aminopeptidase P. These molecules, and...
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6399371 |
Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same
The present invention provides novel complementary DNA (cDNA) sequences encoding human matrix metalloprotease proteins (MMP-ABT). The present invention also provides recombinant DNA molecules...
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6399350 |
KUZ, a novel family of metalloproteases
Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that...
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6399348 |
DNA sequences for matrix metalloproteases, their production and use
DNA sequences for human matrix metalloproteases are disclosed, as well as homologous DNA sequences homologous and derived therefrom. Also disclosed are the proteins and protein variants coded by...
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6391610 |
Nucleic acids encoding zinc metalloproteases
Isolated mammalian proteins having disintegrin-like and metalloprotease domains with thrombospondin type I motifs, i.e., ADAMTS proteins, are provided. The proteins are ADAMTS-5, ADAMTS-6,...
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6391300 |
Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation
This invention provides a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation which comprises contacting the extracorporeal circulating blood...
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6372213 |
Method of treating sickle cell disease or thalassemia
The present invention provides a method of treatment of sickle cell disease (SCD) or thalassemia with protein C. The claimed invention provides a needed therapy for potentially serious and...
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6346245 |
Procedure for extraction and use of hatching fluid from Atlantic salmon
A procedure is described for obtaining valuable endoproteases (or zonases) from hatchery-produced Atlantic salmon eggs. Synchronized hatching by for instance elevated temperature, is followed by...
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6344353 |
Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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6331427 |
Protease homologs
The invention relates to polynucleotides encoding newly identified protease homologs belonging to the superfamily of G-protein-coupled proteases. The invention also relates to the proteases. The...
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6319702 |
Nucleic acids encoding mutant human carboxypeptidase A enzymes
The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes....
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6319681 |
Mammalian TNF-α convertases
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
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6313268 |
Secretases related to Alzheimer's dementia
This invention is directed to a novel β-secretase that produces the Aβ peptide found in Alzheimer's Disease. One β-secretase is a protein having a molecular weight of about 61, 81 or 88 kDa that...
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6303361 |
Human glandular kallikrein-1 (hK2)
A new form of human glandular kallikrein-1 (hK2) found from cloning a prepro-hK2 cDNA from a human protrate cancer tissue cDNA library. The new form differs in sequence from the prior art form in...
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6294363 |
Rapid method of proteasome purification using proteins having sequence homology to ubiquitin
Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin using amino acid sequences adhered to a solid support.
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6294169 |
Interleukin-1 beta converting enzyme like apoptotic protease-6
Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
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6287858 |
DeUBiquitinating enzymes that regulate cell growth
The present invention relates to ubiquitin-specific thiol proteases or deubiquitinating enzymes, referred to as DUB (DeUBiquitinating) enzymes, of eukaryotic origin which are members of a...
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6284247 |
Human tissue plasminogen activators
Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with...
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6284513 |
Process for the production of stromelysin catalytic domain protein
A process for the production of the catalytic domain, without propeptide, of a matrix metalloproteinase is described which comprises culturing transformed host cells carrying a DNA sequence...
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6280994 |
Zace 1: a human metalloenzyme
Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the...
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6277618 |
Recombinant blood-coagulation proteases
The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family:...
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6277590 |
Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These...
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6274336 |
Method of inhibiting cathepsin K
A novel cathepsin K crystalline stucture is identified. Also disclosed are methods of identifying inhibitors of this protease and methods of inhibiting cathepsin K using inhibitors with certain...
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6274366 |
Enzymatically-active recombinant human β-tryptase and method of making same
Disclosed is a method of expressing enzymatically-active, recombinant human β-tryptase in a yeast host cell, expression constructs which drive the production of enzymatically-active tryptase in...
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6274335 |
Method of treatment using recombinant human tissue plasminogen activator
Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with...
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6271013 |
Aspergillus niger aminopeptidase compositions for making bread doughs and cheese
Aminopeptidases originating from Aspergilli niger are disclosed, which can be produced in a fermentation broth or a liquid concentrate thereof substantially free of endoprotease. Such...
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6271014 |
Mammalian proteinases; related reagents and methods
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
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6268344 |
Methods for treating hypercoagulable states or acquired protein C deficiency
A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and...
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6255064 |
Disintegrin metalloprotease and its use
Proteins comprising the amino acid sequence of human disintegrin and DNA sequences encoding the human disintegrin protein are identified. Also described are methods for determining the activity of...
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6235279 |
Method for treating thromboembolic conditions by inhibiting reocclusion via the use of multiple bolus administration of thrombolytically active proteins
Discussed are therapeutic approaches to the treatment of thrombolic conditions. The therapies use thrombolytically active proteins which inhibit reocclusion in the subject. The proteins are...
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6232456 |
Serine protease reagents and methods useful for detecting and treating diseases of the prostate
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present...
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6228618 |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
Methods for enhancing the production of tissue plasminogen activator (tPA) in cell culture are disclosed. The methods involve culturing tPA-producing cells in growth media supplemented with an...
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6228989 |
Peptide substrates phosphorylated by P21-activated protein kinase
The determinants for phosphorylation of substrates by γ-PAK have been identified by examining the kinetics of phosphorylation of a series of synthetic peptides. The recognition sequence for γ-PAK...
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6225103 |
Cloning and characterization of napsin
A previously unknown aspartic protease capable of cleavage of proteins by hydrolysis, referred to herein as "napsin", has been cloned from a human liver library. Two cDNA clones have been cloned,...
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6221645 |
β-secretase antibody
Compositions comprising a novel protease capable of cleaving β-amyloid precursor protein (APP) on the amino-terminal side of the β-amyloid peptide therein are provided. The protease is designated...
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6221657 |
Modified human C3 DNA sequences and vectors
This invention is directed to DNA sequences encoding narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. The modified C3 proteins are...
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6214600 |
Membrane-type matrix metalloproteinase-5 gene
HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and...
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6204043 |
Human macrophage metalloproteinase
A novel 54 kDa human macrophage metalloelastase (HME) having elastolytic activity and the cDNA which encodes for this enzyme are disclosed.
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6187579 |
Customized proteases
The invention provides customized proteases (i.e., mutant enzymes), methods of making customized proteases, as well as methods of using customized proteases. The customized proteases of the...
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6183743 |
Modified factor VII
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to...
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6180386 |
DNA sequences coding for the human proteins Tx and Ty related to the interleukin-1beta converting enzyme
DNA sequences coding for human polypeptides with protease activity and capable of inducing apoptosis, related to the interleukin-1beta converting enzyme are disclosed.
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6168789 |
Modified factor VII
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to...
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6165771 |
Compounds
The HE2NW40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE2NW40 polypeptides and...
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