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6734007 |
Human proteases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6734006 |
Regulation of human transmembrane serine protease
Reagents that regulate human transmembrane serine protease activity and reagents that bind to human transmembrane serine protease gene products can be used to regulate extracellular matrix...
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6722062 |
Capsular polysaccharides from enterococci
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
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6703230 |
47174, a novel human glycosyltransferase and uses thereof
The invention provides isolated nucleic acids molecules, designated 47174 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense...
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6699683 |
Active site of human gamma glutamy hydrolase
Provided is the active site of human gamma glutamyl hydrolase. The active site resides in amino acid residues 110, 171, 220 and 222 of SEQ ID NO:1. Thus provided is an inactive gamma glutamyl...
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6689599 |
Aggrecanase molecules
Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies...
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6682733 |
Fibrinolytic enzymes
A fibrinolytically active plasminogen activator of the tissue type, wherein the growth factor (G) domain has been deleted, and wherein also the K1 domain has been deleted and additionally has been...
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6664093 |
Isolated human zinc metalloprotease proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6656717 |
Cyclic AMP phosphodiesterase isoforms and methods of use
Human and rat cAMP phosphodiesterase isoforms (denoted PDE4Ds), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in...
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6645509 |
Polypeptide expressed in the horny layer of epidermis and use thereof
The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is...
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6645734 |
Serine protease specific monoclonal antibodies and their use
A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by...
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6642368 |
Programmed cell death and caspase-12
This invention relates to nucleic acids encoding caspase-12, proteins encoded by casp-12 nucleic acids, vectors, and hosts transformed with vectors. Caspase-12 is a member of the caspase family,...
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6642041 |
Polynucleotides encoding a novel metalloprotease, MP-1
The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic...
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6638751 |
Isolated human zinc protease proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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6630139 |
Fibrinogenolytic proteases with thrombolytic and antihypertensive activities: medical application and novel process of expression and production
The present invention provides a process of producing highly purified proteases. The invention further provides the use of such purified proteases in treating cardiovascular disorders, including...
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6620606 |
Human cathepsin
The invention provides a new human cathepsin (LCAP) and polynucleotides which identify and encode LCAP. The invention also provides expression vectors, host cells, agonists, antibodies and...
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6620607 |
Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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6607894 |
Matrix metalloproteinase levels as indicators of endometrial cancer
This invention relates to methods for assaying the presence and/or risk of endometrial cancer by measurement of levels of matrix metalloproteinase-2 and/or matrix metalloproteinase-9 in uterine...
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6607897 |
Recombinant proCVF
Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity.
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6596527 |
Composition and methods relating to SENP 1- a sentrin-specific protease
The invention relates to a novel protease, called SENP1, which is active against sentrin-modified proteins in vivo. The invention more specifically relates to the genomic and amino acid sequences...
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6596526 |
Furin polypeptides with improved characteristics
The present invention comprises a furin polypeptide having a modified amino acid sequence between the middle, homo-B-domain and the transmembrane domain compared to wild-type furin which retains...
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6592866 |
Non-selfdegrading endoprotease
The present invention relates to a novel endoproteolytic hatching enzyme called zonase. The new enzyme is a non-selfdegrading endoprotease. The inventors have purified the enzyme to sequence...
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6593118 |
Method for rapidly obtaining crystals with desirable morphologies
The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then...
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6589770 |
Keratinocyte derived protease
Disclosed is an isolated polypeptide comprising an amino acid sequence substantially as shown in SEQ ID NO:2, or substantially similar to an amino acid sequence encoded by a nucleotide sequence in...
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6586225 |
ICE/CED-3 like protease designated FMH-1
Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The...
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6573077 |
Active site of human gamma glutamyl hydrolase
Provided is the active site of human gamma glutamyl hydrolase. The active site resides in amino acid residues 110, 171, 220 and 222 of SEQ ID NO:1. Thus provided is an inactive gamma glutamyl...
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6573062 |
Method for obtaining modulators of TNF receptor releasing enzyme
The present invention relates to methods of regulating TNF activity indirectly by regulating the activity or concentration of TNF receptor releasing enzyme (TRRE). Preferably, the TRRE activity is...
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6569664 |
Native TNF receptor releasing enzyme
The present invention relates to methods of regulating TNF activity indirectly by regulating the activity or concentration of TNF receptor releasing enzyme (TRRE). Preferably, the TRRE activity is...
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6569665 |
Calpaines, production and use thereof
Novel calpains and their preparation, and methods for screening for novel calpain inhibitors and their use are described.
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6566116 |
Matrix metalloprotease
This invention relates to a novel metalloprotease having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA,...
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6555354 |
TNF-α converting enzyme
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of...
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6548284 |
Membrane-bound metalloprotease and soluble secreted form thereof
Disclosed are metalloprotease proteins or their salts usable for treatment or prophylaxis of conformational diseases and for providing a screening kit for selection of carcinostatics and...
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6544767 |
Cathespin O2 protease
The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.
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6541236 |
Protein having glutaminase activity and gene encoding the same
There are disclosed a protein having an amino acid sequence represented by amino acid numbers 1 to 684 or 49 to 684 shown in SEQ ID NO:2, or a protein having a glutaminase activity in which one or...
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6531298 |
Factor IX antihemophilic factor with increased clotting activity
A non-naturally occuring Factor IX protein having an amino acid substitution at amino acid position 338 is provided. Preferred substitutions include the substitution of analanine, leucine, or...
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6524807 |
Modified interleukin-1β converting enzyme with increased stability
Modified forms of human interleukin-1β converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic...
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6524814 |
Enzyme and DNA sequence encoding krill-derived multifunctional protein
The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein...
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6525185 |
Polymorphisms associated with hypertension
The invention discloses a collection of polymorphic sites in genes know or suspected to have a role in hypertension. The invention provides nucleic acids including such polymorphic sites. The...
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6521436 |
Nucleic acids encoding aggrecan degrading metallo proteases
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu 373 -Ala 374 ....
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RE37958 |
DNA sequence coding for protein C
Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors...
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6497877 |
Plasminogen activator as an anti-inflammatory agent
Plasminogen activator acts as an anti-inflammatory agent by inhibiting generation of superoxide anion by a mechanism that is not related to L-arginine, is not dependent on thrombolytic activity,...
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6489451 |
Antithrombosis enzyme from the snake venom of agkistrodon acutus
This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.
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6489296 |
Method of reducing mortality in severe sepsis
A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans , meningococcal sepsis, bone marrow and...
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6482629 |
Isolated human zinc metalloproteases, nucleic acids molecules encoding said enzymes, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6475485 |
Two novel human cathepsin proteins
The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells...
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6472195 |
Human kallikrein
The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists,...
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6455296 |
Apoptotic protease Mch6, nucleic acids encoding same and methods of use
The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The...
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6436691 |
Chemical compounds
Antibody Directed Enzyme Prodrug Therapy (ADEPT) systems for use in cancer based on mutated carboxypeptidase B (CPB) enzymes. Enzyme conjugates for ADEPT are substantially non-immunogenic in humans...
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6432690 |
Human aspartic proteases
The invention provides human aspartic proteases (NHAP) and polynucleotides which identify and encode NHAP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6428998 |
Recombinant N-proteinase and methods and uses thereof
The present invention relates to novel polynucleotide sequences encoding human N-proteinase, and the polypeptides encoded by such polynucleotide sequences. The present invention further relates to...
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