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9034322 Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria  
The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including...
8999641 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8993233 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8945839 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8906662 Compositions and methods for treating inflammatory bowel disease and airway inflammation  
Provided are compositions and methods for treating inflammation due to an immune response. Non-limiting example compositions include class-2 SPATE proteins that are capable of cleaving proteins...
8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8883444 Peptide synthesis using enzymatic activation and coupling  
The invention relates to a method for synthesizing a peptide by enzymatically preparing an ester or thioester from (i) an N-terminal protected amino acid or an N-terminal protected peptide where...
8871445 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8841110 Animal product free system and process for purifying a botulinum toxin  
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
8841111 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
RE45074 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine  
The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid...
8795965 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8778338 Combination enzyme therapy for digestion of dietary gluten  
A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be...
8771945 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8765471 Neutral protease (NP) and product by using neutral protease for tissue dissociation as well as method for the production thereof  
The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a...
8765441 Protease that decomposes proteins recalcitrant to proteolysis  
The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste...
8748151 Clostridial neurotoxins with altered persistency  
The invention relates to a polypeptide comprising: (a) a HC-domain or fragment thereof of the neurotoxic component of a clostridial toxin; and(b) a first LC domain or fragment thereof of the...
8697413 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8697414 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8697359 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8685692 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8685392 Rothia species glutamine endopeptidases and use thereof  
The invention relates to glutamine endopeptidase enzymes from Rothia spp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes...
8685693 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8609087 Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases  
Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides...
8546108 Methods of intracellular conversion of single-chain proteins into their di-chain form  
The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can...
8530205 Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same  
The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly,...
8530217 Processing of peptides and proteins  
The invention provides novel methionine aminopeptidase enzymes and their use.
8512992 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8455235 Protease variants for pharmaceutical use  
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved...
8440445 Neutral protease (NP) and product by using neutral protease for tissue dissociation as well as method for the production thereof  
The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a...
8409828 Animal product free system and process for purifying a botulinum toxin  
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
8377677 Protease variants  
The invention relates to a novel 3D structure encoding a Nocardiopsis protease, as well as to variants of parent protease homologous to Nocardiopsis proteases, preferably of improved...
8357524 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity  
This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine...
RE43795 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine  
The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid...
8198231 Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains  
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective...
8148128 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity  
This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine...
8133483 Method of treating or preventing a disease or condition mediated by pathogenic IgG antibodies  
The invention provides use of an IdeS polypeptide, or a polynucleotide encoding an IdeS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition...
8076297 Pharmaceutical composition containing polypeptide fragments of serralysins  
The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said...
8038990 Compositions and methods for the prevention and removal of biofilms on inert and biological surfaces  
Organisms, compositions, and methods for at least partially reducing the formation of a biofilm and/or at least partially removing a biofilm are provided. The organisms, compositions, and methods...
8008059 Method utilizing enzyme substrates producing insoluble fluorescent products and chromogens, and use in combination with enzyme substrates producing soluble products  
A method of detection of cells, microorganisms, or molecules by the use of various combinations of fluorogens and a chromogens which yield fluorophores and chromophores when cleaved by specific...
7982003 Creating designer antimicrobials; peptidoglycan hydrolase module shuffling  
The invention concerns a nucleic acid encoding a recombinant bifunctional fusion peptidoglycan hydrolase protein formed from a nucleic acid encoding a peptidoglycan hydrolase module and a nucleic...
7956167 Purification of collagenases from clostridium histolyticum liquid culture  
The present invention provides a method for purifying Clostridium histolyticum collagenase type I and type II proteins from a complex mixture by subsequently performing a precipitation with...
7943337 Method for screening a protease  
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor....
7906310 Proteases  
The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent....
7892808 Protease variants  
The invention relates to a novel 3D structure determined for a Nocardiopsis protease, as well as to variants of parent protease homologous to Nocardiopsis proteases, preferably of improved...
7846231 Method of treating organic waste, agent for treating organic waste and microorganisms to be used therein  
There are provided a method of treating organic waste, which is excellent in the smooth temperature elevation in the early stage of the treatment and satisfactory in temperature-maintenance in a...
7794966 Method of measuring glycated amine  
The present invention aims to enable highly reliable measurement of a glycated amine. A fructosyl amino acid oxidase (FAOD) is added to a sample to remove a non-analyte glycated amine that is...
RE41461 Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum  
A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases...

Matches 1 - 50 out of 335 1 2 3 4 5 6 7 >