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5976848 Method of identifying potential fungicides using dihydroorotate dehydrogenase inhibition assay  
Dihydroorotate dehydrogenase (DHOD) inhibititon assays are utilized in a method for identifying new fungicides; DHOD inhibitors are useful in fungicidal methods and compositions. Resistance genes...
5976542 Compositions and methods for treatment of streptococcus pneumoniae infection  
The invention relates to an isolated nucleic acid encoding Streptococcus pneumoniae IgA protease and an isolated polypeptide comprising Streptococcus pneumoniae IgA protease and methods of use...
5977085 Vectors carrying coding sequence for the SpsB protein of Staphylococcus aureus  
spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for...
5972683 Mutant type subtilisin YaB and its application  
The invention provides a group of subtilisin YaB mutants, which are obtained by the substitution of the glycine residues at the 124, 151 and 159 positions of wild type subtilisin YaB with other...
5972682 Enzymatically active modified subtilisins  
Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl...
5968763 Method for screening inhibitors of the enzyme which cleaves the anchor of surface proteins from gram positive bacteria  
The invention relates to an enzyme which cleaves surface proteins of gram-positive bacteria, to methods of detecting the enzyme, and methods of isolating the enzyme. In particular, the enzyme is...
5965424 Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases  
The present invention concerns a process for the isolation of recombinant IgA protease from inclusion bodies. In addition a recombinant DNA is claimed which codes for an IgA protease whose...
5962295 LicB polypeptides from Streptococcus pneumoniae  
The invention provides licB polypeptides and polynucleotides encoding licB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
5955340 Modified subtilisins having amino acid alterations  
Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl...
5951980 Identification, production and use of new staphylokinase derivatives with reduced immunogenicity  
Methods for the identification, production and use of derivatives of the invention obtained by preparing a DNA fragment comprising at least the part of the coding sequence of staphylokinase that...
5952215 Enzyme composition for tissue dissociation  
An enzyme composition and its use for isolating cells or cell clusters from tissue is disclosed. The composition includes two purified collagenase enzymes and an endoprotease. The ratio of the...
5948746 Proteolytic enzymes  
The present invention relates to novel proteolytic enzymes. More specifically, the present invention relates to proteolytic enzymes obtainable from strains of Amycolata and Amycolatopsis. Moreover...
5935573 Method of use of an analog of Haemophilus influenzae Hin47 with reduced protease activity  
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially...
5891669 Methods for producing polypeptides in respiratory-deficient cells  
The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which...
5891701 Nucleic acids encoding a polypeptide having protease activity  
The present invention relates to isolated nucleic acid sequences encoding polypeptides having protease activity, in which the polypeptides are obtainable from an alkalophilic Bacillus species...
5882643 Lep  
lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the...
5877000 Keratinase produced by Bacillus licheniformis  
Bacillus licheniformis O.W.U. 138B and 88B and other bacterial strains capable of degrading feathers isolated from wild birds, are disclosed. The strains and the keratinases produced by these...
5868868 Peg-modified proteases and methods of use in contact lens cleaning  
The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also...
5858357 Pharmaceutical composition containing an isolated protease proenzyme, amylase, and aprotinin  
The invention is directed to a pharmaceutical preparation with a modulatory effect on malignant tumors, which contains a combination of protease proenzymes and amylases in a ratio between 1:100...
5858757 Stabilized enzymes and detergent compositions  
The invention relates to stabilized subtilisin proteases wherein one or more prolines is substituted for a native amino acid at stabilizing positions defined both by the range of the dihedral...
5856167 Hypochlorite stable protease from bacillus SP., DSM 8473  
A protease obtained from Bacillus sp., DSM 8473, is disclosed which has improved hypochlorite stability as compared to other known proteases. The protease is suitable as a detergent additive and...
5856166 Streptomyces proteases and methods for improved secretion of recombinantly-expressed proteins  
A family of proteases endogenous to Streptomyces cells degrades heterologous proteins secreted from Streptomyces host cells. The previously unidentified proteases include (1) tripeptidyl...
5830740 Serine protease operative between 75°C. and 103°C.  
A subtilisin which exhibits proteolytic activity at temperatures ranging from 75° C. to 130° C. The subtilisin has been given the name aerolysin because it was initially isolated from the...
5830741 Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease  
An enzyme composition for dissociating tissues is disclosed. The composition comprises purified collagenase I and collagenase II from Clostridium histolyticum in a mass ratio of about 0.3 to 0.6...
5763256 Serine protease variants having peptide ligase activity  
The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity....
5759538 Bacillus thuringiensis apr and npr genes, apr and npr B.t. strains, and method of use  
The present invention is based on the discovery, isolation, sequencing and characterization of two protease genes present in Bacillus thuringiensis (B.t.). One is an alkaline protease gene...
5756339 Hyperthermostable protease gene  
There is disclosed a hyperthermostable protease gene originating in Pyrococcus furiosus, in particular, a hyperthermostable protease gene encoding the amino acid sequence represented by the SEQ ID...
5747321 Mutant Staphylococcus aureus V8 proteases  
Mutant proteases are obtained with one or more mutation sites in the natural V8 protease protein, and with enzyme activities even in the presence of high urea concentrations.Inactivation of enzyme...
5733767 Gram-negative alkaliphilic microorganisms  
Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These...
5733741 Thermocellulolytic bacteria and their uses  
Thermus aquaticus biovar. Nov. SK542 (FERM BP-3382) is an absolute aerobic bacteria. It grows at temperature limit of 40°-82° C. in a normal concentration medium, but its best growth is achieved...
5728544 Protease II  
A modified protease is disclosed, which is a mutant of the thermostable neutral metallo-protease having the amino acid sequence of SEQ ID NO:1 wherein the 150th aspartic acid residue is replaced...
5728543 Clostripain catalyzed hydrolysis of preproinsulin analogs into corresponding insulins  
A process is described to specifically hydrolyze the amino acid chain of preproinsulin analogs to give the corresponding insulins. The hydrolysis is catalyzed by clostripain and, if necessary,...
5707822 Gene serum opacity factor  
Methods and compositions are provided for cloning and expression of serum opacity factor of Streptococcus pyogenes genes. The portion produced by the recombinant DNA techniques described herein...
5707620 Lysine-specific Porphyromonas gingivalis proteinase  
Provide herein is a substantially pure Lys-gingipain complex preparation, Lys-gingipain being characterized as having an apparent molecular mass of 105 kDa as estimated by sodium dodecyl sulfate...
5705379 Nucleotide sequences encoding a thermostable alkaline protease  
Nucleotide sequences, derived from a thermophilic actinomycete microorganism, which encode a thermostable alkaline protease are disclosed. Also disclosed are variants of the nucleotide sequences...
5695754 Staphylokinase derivatives  
A method for producing the derivatives of the invention by preparing a DNA fragment comprising at least the part of the coding sequence of staphylokinase that provides for its biological activity;...
5683909 Plasmids replicatable in Bacillus subtilis, E. coli and lactic acid streptococcus bacteria  
The claimed invention is drawn to a recombinant plasmid which can replicate in Bacillus subtilis, Escherichia coli, and lactic acid Streptococcus bacteria comprising the replication of origin from...
5674833 Detergent compositions containing protease and novel inhibitors for use therein  
A detergent composition and additive comprising a protease and a reversible protease inhibitor of the peptide or protein type, wherein the ratio of the dissociation constant to the protease...
5665353 Composition containing an analog of haemophilus Hin47 with reduced protease activity  
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially...
5665586 Protease from Streptomyces fradiae  
According to the present invention, a novel protease derived from Streptomyces fradiae for cleaving the C-terminal of a glutamic acid residue in an amino acid sequence of a polypeptide and a...
5663068 Cyanobacterial Δ6-desaturase  
Linoleic acid is converted into γ-linolenic acid by the enzyme Δ6-desaturase. The present invention is directed to an isolated nucleic acid comprising the Δ6-desaturase gene. More particularly,...
5646028 Alkaline serine protease streptomyces griseus var. alkaliphus having enhanced stability against urea or guanidine  
Purified native alkaline protease having an apparent molecular weight of 19,000 daltons and isolated from Streptomyces griseus var. alkaliphilus is provided, as well as methods of making and using...
5643777 Thermostable protease from thermococcus  
This invention is within the field of thermostable proteases. More specifically, the present invention relates to a thermostable protease from Thermococcus celer, Thermococcus stetteri or...
5631217 Detergent compositions comprising a modified subtilisin  
This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production,...
5629173 Methods of use of serine protease variants having peptide ligase activity  
The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity....
5622850 Recombinant methods for the production of a bacillus alkaline protease  
The invention is directed to an isolated nucleic acid construct(s) comprising a nucleic acid sequence encoding an alkaline protease having a molecular weight of about 34 kD and is obtainable from...
5621089 Nucleic acid constructs for the production of a Bacillus alkaline protease  
The invention is directed to an isolated nucleic acid construct(s) comprising a nucleic acid sequence encoding an alkaline protease having a molecular weight of about 34 kD and is obtainable from...
5616485 Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides  
A family of proteases endogenous to Streptomyces cells degrade heterologous proteins secreted from Streptomyces host cells. The previously unidentified proteases include (1) tripeptidyl...
5602021 Method for generating proteolytic enzymes specific against a selected peptide sequence  
The present invention describes methods for screening or selecting novel proteolytic enzymes. These enzymatic functions can be selected from isolated chromosomal DNA libraries or from pools of...
RE35443 Purification of Q Beta replicase  
A process of producing highly pure, Q Beta replicase having a high level of activity is described. The present process allows isolation of Q Beta replicase from recombinant bacteria containing a...
Matches 151 - 200 out of 335 < 1 2 3 4 5 6 7 >