Matches 101 - 150 out of 335 < 1 2 3 4 5 6 7 >


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6623950 Modified enzymes having polymer conjugates  
The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide...
6586224 Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions  
The present invention relates to variants of subtilisin-like proteases having decreased immunogenicity relative to their corresponding wild-type proteases. The present invention further relates to...
6586221 Subtilisin variants multiply-substituted subtilising variants having a substitution at position 76  
Novel carbonyl hydrolase variants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases are disclosed. The variant carbonyl hydrolases, in general, are...
6586223 Subtilisin protease variants having amino acid substitutions in defined epitope regions  
The present invention relates to variants of subtilisin-like proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention...
6545006 Process for obtaining L-dihydroorotic acid and use thereof  
The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa....
6531294 Preparation of pancreatic procarboxypeptidase B, isoforms and muteins thereof and their use  
Pancreatic carboxypeptidase B or an isoform or a mutein of carboxypeptidase B may be prepared by (a) expressing a natural or unnatural enzymatically inactive precursor form of carboxypeptidase B...
6509184 Alkaline tolerant dextranase from streptomyces anulatus  
A process for production of an alkaline tolerant dextranase enzyme comprises culturing a dextran-producing microorganism Streptomyces anulatus having accession no. ATCC PTA-3866 to produce an...
6475764 Recombinant collagenase type I from clostridium histolyticum and its use for isolating cells and groups of cells  
A polypeptide with the properties of collagenase class I from Clostridium histolyticum (CHC I) and the amino acid sequence SEQ ID NO:2 which is optionally N-terminally extended by one or several...
6465235 Non-human carbonyl hydrolase mutants, DNA sequences and vectors encoding same and hosts transformed with said vectors  
Novel carbonyl hydrolase mutants derived from the amino acid sequence of naturally-occurring or recombinant non-human carbonyl hydrolases and DNA sequences encoding the same. The mutant carbonyl...
6465236 Thermostable collagen-digesting enzyme, novel microorganism producing the enzyme and process for producing the enzyme  
Bacillus sp. NTAP-1 having been deposited under accession number FERM BP-6926; and a collagen-decomposing enzyme produced by bacterium. The above enzyme (1) has a capability of hydrolyzing, at the...
6461849 Modified polypeptide  
The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues...
6461834 Clostripain catalyzed amidation of peptides  
The invention provides a method of producing a polypeptide having a C-terminal α-carboxamide group. It particularly concerns an enzymatic modification of selected substrate polypeptides which...
6447773 Member of ATP dependent protease family, clpL  
The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
6448060 Alkalothermophilic bacillus that produces a protease inhibitor  
The present invention relates to a novel strain of alkalothermophilic Bacillus sp. isolated from a hot spring at Vajeshwari, District Thane, The State of Maharashtra, India and deposited at...
6444209 Hybrid botulinal neurotoxins  
A hybrid botulinal neurotoxin is disclosed. In one embodiment, the neurotoxin comprises a combination of a botulinal neurotoxin heavy chain and light chain, wherein the light chain and heavy chain...
6440692 Method of treating hairs or feathers using microorganisms  
Large amounts of hairs and feathers can be decomposed and refined by treatment in an oxygen-containing gas stream with a fungus that can decompose hairs and feathers. The resulting decomposed and...
6413512 Composition and method for treating disease by increasing activated α2 macroglobulin in the blood and extravascular tissue  
A method for treating various diseases and conditions that are dependent on activated α2 macroglobulin in the blood and extravascular tissue is disclosed. The method comprises orally administering...
6403331 Mutant proteolytic enzymes and method of production  
Mutant Bacillus lentus DSM 5483 proteases are derived by the replacement of at least one amino acid residue of the mature form of the B. lentus DSM 5483 alkaline protease. The mutant proteases are...
6383483 Staphylokinase derivatives with cysteine substitutions  
Methods for the identification, production and use of staphylokinase derivatives characterized by a reduced immunogenicity after administration in patients. The derivatives of the invention are...
6380147 Detergents containing amylase and protease  
The invention relates to detergents characterized in that they contain α-amylase from Bacillus amyloliquefaciens and protease from Bacillus lentus, optionally modified by genetic engineering, in...
6358726 Thermostable protease  
A hyperthermostable protease having the amino acid sequence represented by the SEQ ID NO:1 of the Sequence Listing or a sequence derived therefrom by deletion, substitution, insertion or addition...
6350866 Streptococcus pneumoniae gene sequence FtsZ  
The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a...
6306619 DegP periplasmic protease a new anti-infective target and an in vitro assay for DegP protease function  
The DegP (HtrA) protease is a multifunctional protein essential for the removal of misfolded and aggregated proteins in the periplasm. The present invention provides an assay for inhibitors of...
6300116 Modified protease having improved autoproteolytic stability  
The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved...
6299883 Tarf  
The invention provides tarF polypeptides and DNA (RNA) encoding tarF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
6297039 Amps from Streptococcus pneumoniae  
The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
6291229 Gram-positive alkaliphilic microorganisms  
The present invention provides novel aerobic, Gram-positive alkaliphilic bacteria which have been isolated from in and around alkaline soda lakes. These alkaliphiles have been analyzed according...
6284512 Chemically modified mutant enzymes and methods for producing them, and screening them for amidase and/or esterase activity  
The present invention relates to a method for screening chemically modified mutant enzymes for amidase and/or esterase activity. This method includes providing a chemically modified mutant enzyme...
6280993 Gene encoding class I collagenase  
An isolated DNA encoding a class I collagenase, particularly, the isolated DNA encoding the class I collagenase from Clostridium histolyticum, a vector containing the gene, a transformant...
6274718 Porphyromonas gingivalis arginine-specific proteinase coding sequences  
Provided herein is a nucleotide sequence encoding an Arg-specific gingipain, said Arg-gingipain characterized as having an apparent molecular mass of 50 kDa as estimated by sodium dodecyl sulfate...
6271012 Protease muteins and their use in detergents  
New proteolytic enzymes are provided exhibiting improved properties for application in detergents, especially laundry detergents. These enzymes are obtained by expression of a gene encoding a...
6261822 Ultrathermostable protease genes  
There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable...
6214576 Bacteria useful for degrading keratin  
Bacillus licheniformis O.W.U. 138B and 88B and other bacterial strains capable of degrading feathers isolated from wild birds, are disclosed. The strains and the keratinases produced by these...
6214599 Protease  
The object of this invention is to provide a new cysteine protease. The object is achieved by providing a new cysteine protease which is obtained from a flesh fly (Sarcophaga peregrina) and...
6207437 Crystalline protease and method for producing same  
A method for preparing a crystalline protease is provided which comprises preparing an aqueous solution containing the protease enzyme and adding to the aqueous solution sodium sulfate, allowing...
6204008 Bioprocess for production of dipeptide based compounds  
Bioprocesses are disclosed for the production of compounds which can be produced from a dipeptide intermediate. The process comprises production of a recombinant polypeptide which contains the...
6200793 Cold-active protease CP70  
A psychrophilic protease is here disclosed which has the following physicochemical properties: (a) specific activity and substrate specificity: the protease acts on casein, gelatin, hemoglobin and...
6190659 Bacterial plasmin binding protein and methods of use thereof  
The present invention describes a novel polypeptide, and methods of its use in effective thrombolytic therapy in the treatment of coronary and pulmonary thrombosis. Its use is also disclosed in...
6171823 Process for producing extracellular proteins in bacteria  
The invention relates to a method of producing an extracellular protein in a bacterium provided with an inner and an outer cell membrane, the method comprising: (a) providing a recombinant vector...
6156557 Alkaline protease from streptomyces sp. and method for preparing the same  
Disclosed is an alkaline protease having a specific activity of 214,000 (U/mg protein) when using casein as a substrate and 52,700 (U/mg protein) when using keratin as a substrate. The alkaline...
6153580 Analog of haemophilus Hin47 with reduced protease activity  
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially...
6136557 Strepococcus pneumoniae gene sequence FtsH  
The invention provides isolated nucleic acid compounds encoding FtsH of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a...
6133012 Thermostable acyl peptide hydrolase and gene encoding the same  
An acyl peptide hydrolase having an optimum temperature range of 90-95° C. and a gene encoding the same are disclosed. With the above enzyme, it becomes possible to conduct amino terminal analysis...
6121025 Process for producing optically active 3-quinuclidinol derivatives  
The present invention relates to a process for producing optically active 3-quinuclidinol or derivatives, wherein a racemic 3-quinuclidinol ester represented by the general formula (I): ##STR1##...
6117459 Filtration adjuvants, filtration supports, filtration process using them and process for regenerating said adjuvants  
The invention relates to new regenerable filtration adjuvants which are usable for the filtration of liquids, particularly beer at the end of the secondary fermentation storage, characterized in...
6066481 Crystallization of a protein with a sulphur salt  
The present invention relates to a method for crystallization of a protein obtained from a protein-containing solution which involves (a) treating the protein-containing solution with a salt...
6037145 Process for production of protein  
A process for the production of a desired polypeptide comprising the steps of: (1) transforming host cells with an expression vector comprising a gene coding for a fusion protein comprising a...
6017531 Hydrophilic composition containing protease produced by Vibrio  
Hydrophillic compositions and methods of use are provided for debriding and wound healing applications. The compositions contain certain proteases produced by microorganisms of the genus Vibrio.
5989889 Nucleic acids encoding polypeptides having tripeptide aminopeptidase activity  
The present invention relates to isolated nucleic acid sequences encoding polypeptides having tripeptide aminopeptidase activity. The invention also relates; to nucleic acid constructs, vectors,...
5989888 Purified mixture of collagenase I, collagenase II and two other proteases  
A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional...

Matches 101 - 150 out of 335 < 1 2 3 4 5 6 7 >