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7611719 |
Enterovirus, vaccines, medicaments and diagnostic kits
The invention provides a new enteroviral species call EV79, and functional parts, derivatives and analogues of said virus. Proteinaceous molecules capable of specifically binding EV79, such as...
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7608444 |
Use of acid stable protease in animal feed
The present invention relates to acid-stable proteases of the subtilisin family, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the...
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7605115 |
Subtilisin variants
New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues,...
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7604935 |
Soluble rubella E1 envelope protein variants
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the...
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7601528 |
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells...
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7588910 |
Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor....
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7582465 |
Beta secretase genes
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7579180 |
Beta secretase polypeptides
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7572599 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
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7563598 |
Detection of truncation mutations by mass spectrometry
This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal...
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7550282 |
Biological glue based on thrombin-conjugated nanoparticles
Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated...
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7544500 |
Process for the production of a reversibly inactive acidified plasmin composition
Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and...
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7524668 |
Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and...
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7501265 |
Method for producing and cleaving a fusion proteins with an n-terminal chymosin pro-peptide
An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The...
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7494786 |
Mutant proteinase with reduced self-cleavage activity and method of purification
The present invention provides a mutant 27 kDa NIa proteinase having reduce self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant the same substrate...
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7485446 |
Stable retrovirus and methods of use
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold...
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7476528 |
Proteins producing an altered immunogenic response and methods of making and using the same
The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants,...
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7462476 |
Methods for large scale production of recombinant DNA-derived tPA or K2S molecules
The invention belongs to the field of thrombolysis and of tissue plasminogen activator (tPA) derivative production in prokaryotic cells. The invention relates to methods for the production of a...
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7456269 |
Alzheimer's disease secretase, APP substrates thereof, and uses thereof
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell...
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7452683 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
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7442537 |
Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE...
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7429476 |
Acid fungal proteases
The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic...
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7425326 |
Use of collagenase to facilitate guide wire crossing in total arterial occlusions
The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A...
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7410796 |
Proteinase inhibitor, precursor thereof and genetic sequences encoding same
The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid...
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7410774 |
Compounds modulating sister chromatid separation and method for identifying same
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity....
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7407789 |
Recombinant staphylokinase derivatives and the preparation and applications thereof
The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a...
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7399465 |
Pharmaceutical compositions for treating arthritis and inflammatory disease
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
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7393659 |
Analytical method for the determination of infant formula protein digestibility in vitro
A method for in vitro determination of the digestibility of proteins in a nutritional product. The method utilized gastric and intestinal enzymes that are standardized for in vitro digestion...
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7384773 |
Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers...
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7371553 |
Chemically modified enzymes with multiple charged variants
This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the...
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7368272 |
Expression of proteolytic enzymes in koji mold in the presence of carbon sources
The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the...
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7335722 |
Peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
The invention discloses five peptides which can be used as angiotensin converting enzyme inhibitor. The subject invention also discloses a process for the preparation of the products having...
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7332320 |
Protease producing an altered immunogenic response and methods of making and using the same
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that...
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7332160 |
Medical device and method for tissue removal and repair
The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the...
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7329528 |
Enzyme multimer and process of producing same
An enzyme multimer is provided which comprises a plurality of monomer units including a first monomer unit having enzymatic activity and a second monomer unit having enzymatic activity, wherein...
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7319016 |
Crystallization of cathepsin S
Provided are crystals relating to Cathepsin S and its various uses.
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7314744 |
Hyperthermostable protease gene
There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable...
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7311908 |
Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the...
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7306937 |
Multiply-substituted protease variants
Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or re-combinant non-human proteases are disclosed. The variant proteases, in general, are...
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7297528 |
Alkaline protease
An alkaline protease having the following properties; a gene encoding the same; a microorganism producing the same; and washing compositions containing the same; (i) acting over a broad pH value...
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7297508 |
Crystallization of fibroblast activation protein alpha (FAPα)
Provided are crystals relating to FAPα and its various uses.
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7288401 |
Protease variants and compositions
The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved...
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7285408 |
Crystalline form of an n231 mutant catalytic domain of ADAM33 and methods of use thereof
The present invention discloses purified polypeptides that comprise an active human ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides...
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7276364 |
Nucleic acids encoding endotheliases, endotheliases and uses thereof
Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in...
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7264811 |
Purified active HCV NS2/3 protease
A method for producing a refolded, inactive form of recombinantly produced NS2/3 protease which comprises the steps of: a) purifying the protease from inclusion bodies in the presence of a...
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7262034 |
Process for the fermentative preparation of D-pantothenic acid and/or salts thereof
The invention provides a process for the fermentative preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the...
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7258856 |
Proteases from Carica having mitogenic activity and their methods of use
Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the...
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7250271 |
Anti-angiogenesis methods, compositions and uses therefor
This invention relates generally to methods of producing peptide-based anti-angiogenesis compounds using plasmin reductases, and specifically to methods of producing an A 61 anti-angiogenic...
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7223390 |
Insertion of furin protease cleavage sites in membrane proteins and uses thereof
Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual...
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7220716 |
Proteases from gram-positive organisms
The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for ...
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