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5868868 |
Peg-modified proteases and methods of use in contact lens cleaning
The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also...
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5866399 |
Process for inactivating carboxypeptidase Y in hirudin-containing culture broths
The present invention relates to a process for inactivating Carboxypeptidase Y (CPY) in a hirudin-containing culture broth produced by fermenting a transformed yeast. It has been found that...
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5863742 |
Inhibition of protease activity of human whole blood cell lysates
A method of inhibiting proteolytic degradation of a thermally-stable intracellular protein is described. The method involves adding 1 or more denaturing agents to a sample which contains the...
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5861297 |
Detergent-free hepatitis C protease
The protease of Hepatitis C virus (HCV) is purified without detergent, and is useful as a screening tool for HCV antivirals as well as a diagnostic tool for diseases resulting from HCV infection.
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5861267 |
Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
The invention relates to methods for assaying exogenous protease activity in a host cell transformed with nucleotide sequences encoding that protease and a specialized substrate. It also relates to...
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5861263 |
Preparation of preserved entamoeba histolytica antigens without enzymatic inhibitors and their use in immunological methods
The method of the invention relates to the preservation of a complex antigenic system of Entamoeba histolytica molecules, without using enzymatic inhibitors and using these preserved Entamoeba...
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5861291 |
Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof
The present invention relates to an advantageous and novel method of producing pancreatin which contains low amounts of residual organic solvent, and more particularly to a method which is more...
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5858778 |
SF caspase-1 and compositions for making and methods of using the same
A substantially pure protein, Caspase-1, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes Caspase-1, is disclosed. An isolated nucleic acid...
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5856116 |
Crystal structure and mutants of interleukin-1 beta converting enzyme
Interleukin-1β converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1β. The high-resolution structure of human ICE crystallized in complex with...
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5853976 |
Recombinant proteinase from clostridium histolyticum and its use for isolating cells and groups of cells
Process for disintegrating cell tissue and releasing cells or groups of cells contained therein by incubating the cell tissue with a recombinant neutral protease from Clostridium histolyticum which...
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5851815 |
MCH4 and MCH5, apoptotic proteases
The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or...
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5851814 |
Human elastate IV
Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic...
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5849560 |
Proteases causing degradation of amyloid β-protein precursor
A proteolytic factor has been isolated from the brains of humans with Alzheimer's disease which specifically cleaves the peptide having the sequence His-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe (SEQ ID...
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5847085 |
Modified protein C and methods of use thereof
Modified Protein C molecules have been made which substitute the gamma carboxylglutamic acid (Gla) region of another Vitamin K dependent protein, most preferably prothrombin, for the native region...
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5843693 |
Assay method for screening for inhibitors of proTNF conversion
Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is...
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5843694 |
Methods for identification of modulatory compounds for the expression of the NES1 protein
The expression and purification of normal epithelial specific polypeptide (NES 1) which is expressed in normal cells, but not in radiation transformed cells, are described. Both the DNA sequence...
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5843752 |
Soluble active hepatitis C virus protease
Soluble covalent HCV NS3-NS4A complexes comprising the catalytic domain of native HICV NS3 protease fused to an HCV NS4A cofactor, wherein the cofactor has been modified to prevent cleavage by the...
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5843676 |
Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications
The invention relates to novel purified human immunoglobulin E binding factors (IgE-BFs), its individual optionally glycosylated proteins, and fragments thereof, processes for the purification of...
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5840513 |
Antibodies directed to pagC peptides for the detection of salmonellae
The invention relates to agents and methods for the immunological detection of bacteria of the genus Salmonella. The agents according to the invention include peptides whose sequence is selected...
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5834275 |
Process for deodorizing fermented culture broths with superheated steam
A process is provided for deodorizing an aqueous culture broth composition by: (a) providing an aqueous culture broth composition containing odorous compounds in spray form; (b) providing a stream...
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5834249 |
Process for production of protein
A process for production of a desired protein comprising the steps of: a culturing animal cells capable of producing the desired protein in a medium containing trichostatin compounds; and ...
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5830468 |
Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic metalloproteinase, such as MMP-3. The method...
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5830740 |
Serine protease operative between 75°C. and 103°C.
A subtilisin which exhibits proteolytic activity at temperatures ranging from 75° C. to 130° C. The subtilisin has been given the name aerolysin because it was initially isolated from the...
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5830739 |
Proteolytic mixture containing escharase and method of isolating same
Method is described for obtaining a novel proteolytic mixture containing escharase from bromelain.
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5824876 |
Plant parasitic nematode control
A method of controlling nematodes, the method includes the steps of identification of a gene induced within a successfully infected plant by nematode infection of said plant and modifying the gene...
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5824305 |
Method of treating diseases mediated by cyclic nucleotide pathways with purified stem bromelain protease
The present invention relates to a method of treating various diseases and conditions which are dependent on cyclic nucleotide pathways with purified stem bromelain protease. Administration of...
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5821088 |
Use of gram-positive bacteria to express recombinant proteins
A novel system for cloning and expression of genes in gram-positive bacteria. The expression system is based on the finding that many gram-positive bacteria sort proteins to their cell surface...
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5811252 |
Modified proenzymes as substrates for proteolytic enzymes
Detection or determination of a protease in a sample by incubating the sample with a substrate of the protease and observing proteolytic cleavage of said substrate. The substrate is a modified...
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5811095 |
Basal and chitinase broth compositions for enhancing anti-fungal activity of a chemical fungicide and methods for preparing and using same
An insecticidal composition and its method of preparation are presented. The composition comprises a basal broth, a chitinase broth and a chemical fungicide. The basal broth has proteins hydrolyzed...
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5798247 |
Organic-chemical compound with ice-inhibitory action
Organic chemical compounds with ICE-inhibitory action which have structures such that they enter into an interaction with binding sites in a binding cavity.
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5789220 |
Production of γ-linolenic acid by a Δ6-desaturase
Linoleic acid is converted into γ-linolenic acid by the enzyme Δ6-desaturase. The present invention is directed to isolated nucleic acids comprising the Δ6-desaturase gene. More particularly,...
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5786187 |
Method for reducing neuronal degeneration associated with seizure
The invention provides a method for regulating neuronal degeneration resulting from injury to nervous tissue. The method includes regulating the expression or activity of protease, preferably...
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5776754 |
Preserved cell preparations for flow cytometry and immunology
This invention discloses a population of cells which have been preserved in non-frozen hydrated form, and which have been chemically treated in a manner that renders them metabolically inert and...
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5776758 |
Cysteine protease derived from parasitic helminths
The immunosuppressive drug of the present invention can suppress both delayed-type hypersensitivity and antibody production against specific antigens and graft tissues and induce immunological...
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5766916 |
Hepatitis G virus protease
The protease necessary for polyprotein processing in Hepatitis G virus (HGV) is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are...
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5766917 |
Method for identifying and producing a protease capable of cleaving the TNF receptor
Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
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5766897 |
Cysteine-pegylated proteins
Methods and compositions are provided for the production of PEGylated proteins having polyethylene glycol covalently bound to a cysteine residue present in either the naturally-occurring protein or...
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5759538 |
Bacillus thuringiensis apr and npr genes, apr and npr B.t. strains, and method of use
The present invention is based on the discovery, isolation, sequencing and characterization of two protease genes present in Bacillus thuringiensis (B.t.). One is an alkaline protease gene...
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5759541 |
Recombinant fibrinogenases, the preparation and use thereof
Novel polypeptides having fibrinogenolytic properties and having amino acid sequences as SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6 indicated in the Sequence Listing, the preparation...
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5756338 |
Aspergillus niger vacuolar aspartyl protease
The present invention concerns a novel DNA sequence coding for an Aspergillus aspartic protease, an Aspergillus aspartic protease per se and a method for the preparation thereof. The invention...
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5756339 |
Hyperthermostable protease gene
There is disclosed a hyperthermostable protease gene originating in Pyrococcus furiosus, in particular, a hyperthermostable protease gene encoding the amino acid sequence represented by the SEQ ID...
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5747322 |
Recombinant crab collagenase
An isolated sequence is provided that encodes crab procollagenase (Seq ID NO 5) that upon cleaving off the 29 amino acid propeptide (Seq ID NO 6) transforms into an active collagenase (Seq ID NO...
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5744339 |
Thiomethylene group-containing aldehyde cysteine and serine protease inhibitors
The present invention is directed to thiomethylene group-containing aldehyde inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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5744346 |
β-secretase
Compositions comprising a novel protease capable of cleaving β-amyloid precursor protein on the amino-terminal side of the β-amyloid peptide therein are provided. The protease is designated...
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5739025 |
Method for producing an asparaginyl endoprotease
A method is provided for preparing an asparaginyl endoproteinase from the seeds of soybean, ginkgo and rice which have been collected between an early growing stage and ripening. The method...
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5739002 |
Method for reproducing in vitro the Proteolytic activity of the NS3 protease of hepatitis C virus (HCV)
This is a method for reproducing in vitro the serine protease activity associated with the HCV NS3 protein, that comprises using both of the sequences contained in NS3 and the sequences contained...
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5728559 |
Separation of proteins
The present invention relates to a method of separating a protein, in particular an enzyme, from an aqueous solution of proteins, comprising (a) providing an aqueous mixture of proteins with a salt...
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5728566 |
Tissue plasminogen activator derivatives
Tissue plasminogen activator (t-PA) derivatives are produced in useful quantifies using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid...
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5728544 |
Protease II
A modified protease is disclosed, which is a mutant of the thermostable neutral metallo-protease having the amino acid sequence of SEQ ID NO:1 wherein the 150th aspartic acid residue is replaced...
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5716834 |
Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
Full-length and deletion subclones of cDNAs for Factor C of Carcinoscorpius rotundicauda are provided. These cDNAs have been cloned into λgt 22 and pGEM 11Zf(+). Further manipulations of the 5'...
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