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6083711 |
Proteases compositions capable of binding to said site, and methods of use thereof
Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of...
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6077694 |
Method for over-expression and rapid purification of biosynthetic proteins
The subject invention relates to a method of producing and purifying large quantities of a biosynthetic protein. The gene which codes for the protease is placed between the binding domain of a gene...
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6068990 |
Proteins, their production and use
This invention relates to a novel calpain having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a...
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6066481 |
Crystallization of a protein with a sulphur salt
The present invention relates to a method for crystallization of a protein obtained from a protein-containing solution which involves (a) treating the protein-containing solution with a salt...
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6066488 |
Cathepsin C homolog
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for...
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6063592 |
Kell protein proteolytic activity
A method for cleaving polypeptides includes contacting a polypeptide with a recombinant or isolated Kell protein having proteolytic activity for the polypeptide. A method for converting big...
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6057119 |
Crystal structure and mutants of interleukin-1β converting enzyme
Interleukin-1β converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1β. The high-resolution structure of human ICE crystallized in complex with...
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6057143 |
Recombinant enzymatically active calpain expressed in a baculovirus system
The present invention is directed to mammalian enzymatically active calpain produced in insect cells by recombinant means. Recombinant vectors and baculoviruses containing cDNA encoding the 80 kDa...
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6048720 |
Conjugates of a polypeptide and a biocompatible polymer
Processes for improving the in vivo function of factor VIII by shielding exposed targets of the factor VIII comprise a) immobilizing the factor VIII by interaction with a group-specific adsorbent...
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6043075 |
Endoglucanase
An endoglucanase obtainable from Dictyoglomus exhibiting optimum activity at a temperature above 85° C. is disclosed.
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6040155 |
Multifunctional protein and DNA sequence encoding same
The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein...
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6037139 |
System for assaying modulators of procollagen maturation
Potential modulators of a procollagen-cleaving enzyme are assessed by determining the ability of the enzyme to cleave procollagen in the presence and absence of a potential modulator in the culture...
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6037145 |
Process for production of protein
A process for the production of a desired polypeptide comprising the steps of: (1) transforming host cells with an expression vector comprising a gene coding for a fusion protein comprising a...
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6036983 |
Method of obtaining protein hydrolysates
The present invention relates to a method of obtaining protein hydrolysates useful as flavoring agents. More specifically, the invention provides a method of obtaining from a proteinaceous sustrate...
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6033894 |
Kaposi's Syndrome Herpesvirus protease and assembly protein compositions and methods
Kaposi's Sarcoma Herpesvirus (KSHV) protease and assembly protein sequences are disclosed. Also disclosed are polynucleotides that encode the protease and assembly protein. The invention includes...
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6033664 |
Use of a preparation comprising a plasminogen activator to improve wound healing
The present invention relates to the use of non-bacterial plasminogen activators in the manufacture of a topical medical preparation for the treatment of slow- or non-healing wounds. In addition,...
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6027911 |
Bovine dipeptidylaminopeptidase 1
The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from...
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6022698 |
Method and components for the detection of yeasts and/or molds in a sample
A composition for use in a medium for detecting yeasts and molds in a test sample, the composition comprises a substrate for an aminopeptidase; and a signal moiety linked to the substrate, the...
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6020181 |
Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase
The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic matrix metalloproteinase, preferably an...
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6017531 |
Hydrophilic composition containing protease produced by Vibrio
Hydrophillic compositions and methods of use are provided for debriding and wound healing applications. The compositions contain certain proteases produced by microorganisms of the genus Vibrio.
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6010893 |
Process for producing human matrilysin by means of recombinant DNA
The present invention relates to a process for producing a human matrilysin characterized in that a human promatrilysin is expressed in E. coli and secreted into the periplasm thereof; the...
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6008006 |
Determination of glycated proteins
The amount of glycated proteins in a sample can be quantified by reacting the sample with first a reagent which is a combination of a protease and a peroxidase and second with a ketoamine oxidase....
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5990276 |
Synthetic inhibitors of hepatitis C virus NS3 protease
An inhibitor of the HCV NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a subsequence of the NS4A cofactor. Another inhibitor of the present invention contains a...
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5989600 |
Method for improving the solubility of vegetable proteins
The present invention relates to a method for improving the solubility of vegetable proteins. More specifically, the invention relates to methods for the solubilization of proteins in vegetable...
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5989888 |
Purified mixture of collagenase I, collagenase II and two other proteases
A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional...
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5985629 |
Cleaning and disinfecting contact lenses with a protease and chloramine-T or chloramine-B
Contact lens are cleaned and disinfected by contacting with an enzyme that functions as a cleaning agent by degrading deposits on the lens, and with an enzyme inhibitor that inhibits remaining...
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5985590 |
Expression of Carcinoscorpius rotundicauda Factor C in eukaryotes
CrFC21 cDNA was cloned into two mammalian vectors: pCIneo and pCDNAI, both of which carry the strong CMV promoter for expression in mammalian cell lines. Various CrFC cDNA constructs transformed...
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5986079 |
Expression of pace in host cells and methods of use thereof
Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins...
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5981235 |
Methods for isolating nucleic acids using alkaline protease
Solutions containing nucleic acids are treated with an alkaline protease to digest proteins such as nucleases that degrade the nucleic acids. In the isolation of nucleic acids, a biological sample...
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5981470 |
Uterine fibroid treatment
The use of a) an angiotensin-converting enzyme (ACE) inhibitor such as Captopril or Enalapril, b) an angiotensin II-receptor antagonist such as Saralasin or Losartan, or c) a renin inhibitor, such...
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5981240 |
Enzyme-catalyzed synthesis of macromolecules in organic solvents
A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion...
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5972681 |
Calcium-requiring prothrombin activator
An object of the present invention is to provide a novel prothrombin activator. The application of the activator to thrombin-related diseases is expected. Described is a prothrombin activator...
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5972680 |
Glucose transporter vesicle aminopeptidase
An aminopeptidase which is a component of GLUT4-containing vesicles in the natural state, and which cleaves insulin. The claimed protein has an apparent molecular weight of approximately 110 kD in...
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5968763 |
Method for screening inhibitors of the enzyme which cleaves the anchor of surface proteins from gram positive bacteria
The invention relates to an enzyme which cleaves surface proteins of gram-positive bacteria, to methods of detecting the enzyme, and methods of isolating the enzyme. In particular, the enzyme is...
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5968795 |
Biaryl acetylenes as inhibitors of matrix metalloproteases
Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the...
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5962301 |
Relatedness of human interleukin-1β convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor
Described herein is the discovery that human interleukin-1β convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational...
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5962264 |
Method of reducing the proteolytic degradation of bacillus thuringiensis insecticidal toxic protein
The present invention is based on the discovery, isolation, sequencing and characterization of two protease genes present in B.t. One is an alkaline protease gene generally designated "apr." The...
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5958722 |
Use of recombinant inhibitor from Erythrina caffra for purifying serine proteases
Process for purifying serine proteases from a protein mixture by binding the serine protease to an immobilized polypeptide with the activity of an inhibitor DE-3 from Erythrina caffra, removing...
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5942262 |
Biscuit doughs and biscuits products and methods of producing same
A dough suitable for baking biscuits is presented which comprises a proteinase which is at least partially inactivated by oxidation with an oxidizing agent and a second enzyme which produces the...
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5939288 |
Plant secretory signal peptides and nectarins
Provided herein are signal peptides, and constructs and vectors having signal peptides, as well as methods of using signal peptides to deliver proteins into secretory material. The invention...
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5935815 |
Process for micro biological production of proteins
The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process in the in vitro cleavage of a protein by treating the protein in...
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5922587 |
Phospholipid dependent prothrombin activator obtained from snake venom
It was found that the use of a phospholipid dependent prothrombin activator purified from the venom of snakes belonging to the Elapidae family, especially members of the Oxyuranus and Psuedonaja...
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5922546 |
Human disintegrin metalloprotease KUZ gene
Human KUZ polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human KUZ polypeptides and...
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5919689 |
Marine antifouling methods and compositions
Disclosed are marine antifouling compositions and/or paints containing, microorganism(s), or mixtures of hydrolytic enzyme(s) and microorganism(s), wherein the microorganism or hydrolytic enzyme...
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5912158 |
Prostate specific antigen (PSA)-proteinase inhibitor complexes
Prostate specific antigen (PSA) is a protein that can form complexes with proteinase inhibitors such as α 1 -antichymotrypsin. The invention is characterized in that the measurement of the ratio...
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5908625 |
Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
The invention relates to the use of thromboembolic proteins. These contain, as their only structural portion effecting thrombolytic activity, the protease domain of human tissue type plasminogen...
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5891669 |
Methods for producing polypeptides in respiratory-deficient cells
The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which...
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5891661 |
Low temperature assay for active HCMV protease in dimeric form
At low temperature, the protease of human cytomegalovirus (HCMV) is rendered highly active as a dimer of identical units. The protease is useful as a screening tool for HCMV antivirals as well as a...
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5882643 |
Lep
lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the...
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5879942 |
Processing enzyme for polypeptide
Disclosed are an enzyme or a protein which converts a precursor of a polypeptide that induces IFN-γ production in an immunocompetent cell into the active form, a process for producing the enzyme...
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