|
Match
|
Document |
Document Title |
|
|
6420147 |
Haloalkaliphilic microorganisms
Haloalkaliphilic bacteria have been isolated from samples of soil, water, sediment, trona (NaHCO 3 .Na 2 CO 3 .2H 2 O) and a number of other sources obtained from in and around hypersaline soda...
|
|
|
6410704 |
Methods and compositions for the preparation and use of a herpes protease
The present invention relates to the identification and purification of a herpes protease and a nucleic acid segment coding for two proteins. The first protein is the herpes protease which is able...
|
|
|
6410296 |
Herpes virus proteinase and method of assaying
A herpes virus proteinase has been found to be encoded by a member of a family of four nested genes in simian cytomegalovirus. Another member of the nested genes encodes the assembly protein...
|
|
|
6406901 |
TNF-a converting enzyme
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of...
|
|
|
6406902 |
Herpes virus proteinase and methods of assaying
A herpes virus proteinase has been found to be encoded by a member of a family of four nested genes in simian cytomegalovirus. Another member of the nested genes encodes the assembly protein...
|
|
|
6403331 |
Mutant proteolytic enzymes and method of production
Mutant Bacillus lentus DSM 5483 proteases are derived by the replacement of at least one amino acid residue of the mature form of the B. lentus DSM 5483 alkaline protease. The mutant proteases...
|
|
|
6403350 |
Method for rapidly obtaining enzyme crystals with desirable morphologies
The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then...
|
|
|
6399371 |
Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same
The present invention provides novel complementary DNA (cDNA) sequences encoding human matrix metalloprotease proteins (MMP-ABT). The present invention also provides recombinant DNA molecules...
|
|
|
6399348 |
DNA sequences for matrix metalloproteases, their production and use
DNA sequences for human matrix metalloproteases are disclosed, as well as homologous DNA sequences homologous and derived therefrom. Also disclosed are the proteins and protein variants coded by...
|
|
|
6391610 |
Nucleic acids encoding zinc metalloproteases
Isolated mammalian proteins having disintegrin-like and metalloprotease domains with thrombospondin type I motifs, i.e., ADAMTS proteins, are provided. The proteins are ADAMTS-5, ADAMTS-6,...
|
|
|
6391575 |
Methods for detecting membrane derived caspase activity and modulators thereof
Provided are methods for detecting membrane derived apoptotic activity. In one embodiment, the present invention provides methods for identifying membrane derived caspase activity. In other...
|
|
|
6380147 |
Detergents containing amylase and protease
The invention relates to detergents characterized in that they contain α-amylase from Bacillus amyloliquefaciens and protease from Bacillus lentus , optionally modified by genetic engineering,...
|
|
|
6365391 |
Isolated human serine protease, nucleic acid molecules encoding human serine protease, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
|
|
|
6361975 |
Mouse aspartic secretase-2(mASP-2)
mASP-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either...
|
|
|
6358726 |
Thermostable protease
A hyperthermostable protease having the amino acid sequence represented by the SEQ ID NO:1 of the Sequence Listing or a sequence derived therefrom by deletion, substitution, insertion or addition...
|
|
|
6355455 |
Method for enzymatic synthesis of sucrose esters
A method for the enzymatic synthesis of sucrose ester, comprises introducing, in an adapted reactor and so as to form a reaction medium, predetermined amounts of an organic solvent, a sugar or a...
|
|
|
6355228 |
Oral care product comprising a mutan binding domain
Disclosed is a polypeptide hybrid containing an amino acid sequence with binding affinity for mutan, the amino acid sequence being bound to an active component useful for oral care purposes; an...
|
|
|
6350573 |
Methods for identifying herbicidal agents that inhibit D1 protease
D1 protease has been isolated from the alga ( Scenedesmjus obliquus ), wheat, and Synechocystis PCC 6803 and the genes encoding these enzymes have been cloned and sequenced. Native or recombinantly...
|
|
|
6346276 |
Composition containing useful substances originating in fishes and shellfishes and process for the preparation of the substances
A process for producing water-insoluble substances derived from fishes and shellfishes, includes the treating of the waste of fishes and shellfishes containing the substances with proteolytic...
|
|
|
6346244 |
Fungal protein disulfide isomerase
The present invention relates to protein disulfide isomerases which are encoded by a nucleic acid sequence which hybridizes with (i) the DNA sequence of SEQ ID NO:1 or (ii) the DNA sequence of SEQ...
|
|
|
6346245 |
Procedure for extraction and use of hatching fluid from Atlantic salmon
A procedure is described for obtaining valuable endoproteases (or zonases) from hatchery-produced Atlantic salmon eggs. Synchronized hatching by for instance elevated temperature, is followed by...
|
|
|
6342381 |
Enzyme stabilization with pre-superpolyamide or pre-fiber-forming polyamide oligomers
Enzymes are stabilized with pre-superpolyamide or pre-fiber-forming polyamide oligomers having a polymer chain backbone containing only secondary amide linkages. The polyamide is combined with an...
|
|
|
6337069 |
Method of treating rhinitis or sinusitis by intranasally administering a peptidase
The present invention is directed to methods of treating mucosal inflammation associated with rhinitis or sinusitis by administering peptidases that recognize and cleave polypeptides at Xaa-Pro...
|
|
|
6333167 |
Methods and reagents for identifying inhibitors of proteolysis of membrane-associated proteins
The present disclosure provides DNA constructs, genetically modified host cells and methods for identifying inhibitors of proteolysis of membrane-associated protease substrates including, but not...
|
|
|
6319681 |
Mammalian TNF-α convertases
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
|
|
|
6316240 |
Recovery of a glycosidase or peptidase from a culture broth at high pH
The present invention relates to a method for recovering a glycosidase or a peptidase from a culture solution from an unsolubilized state within said solution to a solubilized state within said...
|
|
|
6315996 |
Topical lysostaphin therapy for staphylococcus ocular infections
A method has been discovered for using lysostaphin as an effective antibiotic for topical treatment of Staphylococcus corneal infections (keratitis). Lysostaphin applied topically to the cornea by...
|
|
|
6316241 |
Alpha/beta hydrolase-fold enzymes
The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention...
|
|
|
6303359 |
DNA molecule encoding new aminopeptidase, and method of producing the aminopeptidase
Disclosed are cDNA encoding a new aminopeptidase derived from germinated soybeans, a recombinant expression vector containing the DNA, a transformant obtained by the transformation with the...
|
|
|
6303361 |
Human glandular kallikrein-1 (hK2)
A new form of human glandular kallikrein-1 (hK2) found from cloning a prepro-hK2 cDNA from a human protrate cancer tissue cDNA library. The new form differs in sequence from the prior art form in...
|
|
|
6303287 |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure...
|
|
|
6303329 |
Method for autoactivation of procaspase 8
A novel recombinant procaspase 8 protein lacking the death effector domains and a method for converting said novel procaspase protein to full active human caspase 8 by concentration of the...
|
|
|
6297039 |
Amps from Streptococcus pneumoniae
The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS...
|
|
|
6294363 |
Rapid method of proteasome purification using proteins having sequence homology to ubiquitin
Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin using amino acid sequences adhered to a solid support.
|
|
|
6294332 |
Composition and methods for modulating the length of telomeres
The present invention relates to the length of telomeres and the role of hnRNP A1, UP1 or derivatives thereon. More particularly, the present invention relates to hnRNP A1, UP1 or derivatives...
|
|
|
6294169 |
Interleukin-1 beta converting enzyme like apoptotic protease-6
Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
|
|
|
6291201 |
Fluorescence energy transfer substrates
A method for the preparation of a fluorescence resonance energy transfer (FRET) substrate having donor and acceptor species on opposite sides of a proteolytic cleavage site and wherein the donor...
|
|
|
6287840 |
Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which...
|
|
|
6288037 |
Substrates and inhibitors for cysteine protease ICH-1
Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible...
|
|
|
6287795 |
Mch4 and Mch5, apoptotic protease, nucleic acids encoding and methods of use
The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or...
|
|
|
6284512 |
Chemically modified mutant enzymes and methods for producing them, and screening them for amidase and/or esterase activity
The present invention relates to a method for screening chemically modified mutant enzymes for amidase and/or esterase activity. This method includes providing a chemically modified mutant enzyme...
|
|
|
6277618 |
Recombinant blood-coagulation proteases
The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family:...
|
|
|
6277617 |
Chemically modified enzymes
Modified enzymes are provided in which at least one amino acid, such as asparagine, leucine, methionine or serine, of an enzyme is replaced with a cysteine and the thiol hydrogen is replaced with a...
|
|
|
6274366 |
Enzymatically-active recombinant human β-tryptase and method of making same
Disclosed is a method of expressing enzymatically-active, recombinant human β-tryptase in a yeast host cell, expression constructs which drive the production of enzymatically-active tryptase in...
|
|
|
6274365 |
Pharmaceutical composition having an endoproteolytic activity
The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in...
|
|
|
6271014 |
Mammalian proteinases; related reagents and methods
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
|
|
|
6268344 |
Methods for treating hypercoagulable states or acquired protein C deficiency
A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and...
|
|
|
6265198 |
Parasite astacin metalloendopeptidase proteins
The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and...
|
|
|
6261820 |
Fibronolytically active polypeptide
A fibrinolytically active metalloproteinase polypeptide (called "novel acting thrombolytic") which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant...
|
|
|
6255064 |
Disintegrin metalloprotease and its use
Proteins comprising the amino acid sequence of human disintegrin and DNA sequences encoding the human disintegrin protein are identified. Also described are methods for determining the activity of...
|