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6617145 |
DNA molecules encoding fibrinolytically active polypeptide
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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6610475 |
Kits for processing biological specimens for nucleic acid hybridization assays, target amplification reactions and similar uses
The present invention features kits for making available a desired nucleic acid contained in a biological sample. The kits contain an acid for acidifying the biological sample to a pH at which...
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6610526 |
Human E1-like protein
The invention provides a human E1-like protein (HELPR) and polynucleotides which identify and encode HELPR. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6607894 |
Matrix metalloproteinase levels as indicators of endometrial cancer
This invention relates to methods for assaying the presence and/or risk of endometrial cancer by measurement of levels of matrix metalloproteinase-2 and/or matrix metalloproteinase-9 in uterine...
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6592866 |
Non-selfdegrading endoprotease
The present invention relates to a novel endoproteolytic hatching enzyme called zonase. The new enzyme is a non-selfdegrading endoprotease. The inventors have purified the enzyme to sequence...
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6593118 |
Method for rapidly obtaining crystals with desirable morphologies
The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then...
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6586225 |
ICE/CED-3 like protease designated FMH-1
Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The...
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6586221 |
Subtilisin variants multiply-substituted subtilising variants having a substitution at position 76
Novel carbonyl hydrolase variants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases are disclosed. The variant carbonyl hydrolases, in general, are...
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6586222 |
Recombinant PR-3 and compositions thereof
Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is...
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6579689 |
Modulation of &ggr -secretase activity
The present invention provides cell-free γ-secretase activity. The method of the invention utilizes a membrane source of APP/γ-secretase mixture in the assay to determine factors that may enhance...
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6569665 |
Calpaines, production and use thereof
Novel calpains and their preparation, and methods for screening for novel calpain inhibitors and their use are described.
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6569636 |
Assay for modulators of metallo-enzyme activity
An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of...
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6566338 |
Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy and radiation therapy and for treating and ameliorating the side effects of...
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6562613 |
Recombinant C-proteinase and processes, methods and uses thereof
The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools,...
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6548279 |
D-enzyme compositions and methods of their use
D-enzyme compositions are described comprising an amino acid residue sequence that defines an polypeptide able to catalyze an enzymatic reaction. The D-enzyme has an amino acid residue sequence...
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6544767 |
Cathespin O2 protease
The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.
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6537968 |
Treatment of lupus erythematosus
The present invention provides for the treatment of an individual suffering from lupus erythematosus utilizing a serine protease inhibitor. The treatment includes the use of a corticosteroid that...
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6531290 |
Mammalian TNF- α convertase
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
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6528299 |
Protease for activating clotting factor VII
A protease for activating the blood clotting factor VII, which is inhibited by the presence of aprotinin, is increased in its activity by calcium ions and/or heparin or heparin-related substances,...
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6524807 |
Modified interleukin-1β converting enzyme with increased stability
Modified forms of human interleukin-1β converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic...
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6524814 |
Enzyme and DNA sequence encoding krill-derived multifunctional protein
The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein...
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6521436 |
Nucleic acids encoding aggrecan degrading metallo proteases
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu 373 -Ala 374 ....
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6518054 |
Metallo-endopeptidases
The present invention provides genes encoding variants of metallo-endopeptidases that have been engineered to be resistant to prolonged boiling while having maintained their enzymatic performance...
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6511959 |
Use of calcium-activated neutral protease (CANP) inhibitors in pharmaceutical preparations
The invention provides to the use of inhibitors of calcium-activated neutral proteases (CANPs) and their pharmaceutically acceptable addition salts or their active subunits in the field of tumor...
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6511371 |
Nucleic acids encoding polypeptides having proteolytic activity
The present invention relates to isolated nucleic acid sequences encoding polypeptides having proteolytic activity. The invention also relates to nucleic acid constructs, vectors, and host cells...
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6495322 |
RAIDD, a novel death adaptor molecule
The present invention relates to a novel molecule involved in the process of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human RAIDD protein and splice...
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6495136 |
Proteases having modified amino acid sequences conjugated to addition moieties
Protease conjugates such as subtilisin conjugates are provided comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a...
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6495358 |
Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
Compounds of the general formula I are provided: and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R i capable of binding at a primary specificity site of a...
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6489451 |
Antithrombosis enzyme from the snake venom of agkistrodon acutus
This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.
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6489296 |
Method of reducing mortality in severe sepsis
A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans , meningococcal sepsis, bone marrow and...
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6485956 |
Testis-specific human SVPH1-8 proteinase
The disclosure provides purified and isolated SVPH1-8 polypeptides, nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies...
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6482629 |
Isolated human zinc metalloproteases, nucleic acids molecules encoding said enzymes, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6479274 |
DNA molecules encoding human HELA2 or testisin serine proteinases
The present invention related generally to novel molecules and more particularly novel proteinaceous molecules involved in or associated with regulation of cell activities and/or viability. The...
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6475485 |
Two novel human cathepsin proteins
The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells...
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6472199 |
Method of cleaning dairy pipelines using enzyme pretreatment
Improved, non-chlorinated systems and methods for removing soils from hard surfaces are provided wherein such surfaces are initially contacted with a first aqueous use dispersion including a...
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6465234 |
N-end rule pathway enzymes
This invention relates to an isolated nucleic acid fragment encoding an enzyme involved in the N-end rule pathway of protein degradation. The invention also relates to the construction of a...
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6465236 |
Thermostable collagen-digesting enzyme, novel microorganism producing the enzyme and process for producing the enzyme
Bacillus sp. NTAP-1 having been deposited under accession number FERM BP-6926; and a collagen-decomposing enzyme produced by bacterium. The above enzyme (1) has a capability of hydrolyzing, at the...
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6461849 |
Modified polypeptide
The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues...
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6458557 |
Enhancing growth in gram-positive microorganisms using formate supplementation and inactivation of formate-associated transport proteins
The present invention relates to the formate transport system in gram-positive microorganisms and provides methods for the production of products in a gram-positive microorganism. The present...
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6455296 |
Apoptotic protease Mch6, nucleic acids encoding same and methods of use
The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The...
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6451586 |
Enzyme preparation containing protease
Powdered or granulated enzyme preparations, free of surface active agents and containing a protease as the active enzyme, wherein the protease is present as a tannin complex, with the proviso that...
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6451978 |
Purification of antithrombin-III-α and β
PROTEIN PURIFICATION I The invention relates to processes for preparation of substantially pure antithrombin-III (AT-III), the antithrombin isoforms AT-IIIα and AT-IIIβ; and/or histidine-rich...
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6451548 |
Methods for screening for specific inhibitors of trap and identifying compounds for treatment of diseases or conditions resulting in increased bone resorption using activated TRAP
The invention relates to the use of activated TRAP (tartrate-resistant and purple acid phosphatases) for screening for specific inhibitor of TRAP activity useful in the treatment of diseases or...
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6451574 |
Proteinase K variants having decreased adsorption and increased hydrolysis
The present invention relates to Proteinase K variants having a modified amino acid sequence of wild-type Proteinase K amino acid sequence, the wild-type amino acid sequence comprising a first loop...
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6447773 |
Member of ATP dependent protease family, clpL
The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
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6444457 |
Methods for identifying herbicidal agents that inhibit D1 protease
D1 protease has been isolated from the alga ( Scenedesmjus obliquus ), wheat, and Synechocystis PCC 6803 and the genes encoding these enzymes have been cloned and sequenced. Native or recombinantly...
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6440410 |
Reducing oxysterols with extracts of Morinda citrifolia, red wine, prune, blueberry, pomegranate, apple and enzymes
Compositions and methods are provided for reducing oxysterol buildup in the blood and normalizing cholesterol and blood pressure, in a mammal. The compositions comprise Morinda citrifolia ...
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6436397 |
Activated protein C formulations
The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated...
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6436689 |
Isolated nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequence of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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6423526 |
Human serine protease
Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These...
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