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4898826 |
Method to solubilize tissue plasminogen activator
Practical amounts of tissue plasminogen activator (tPA) whether secreted by cells naturally producing it or prepared by recombinant means can be solubilized by providing, in aqueous medium at pH...
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4897352 |
Acrylate based adsorbent resin for the immobilization of enzymes
Enzymes are immobilized on macroporous hydrophilic polymer beads by adsorption. The polymer beads are cross-linked, acrylate-based resins containing pendant hydroxy groups. The resins contain...
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4892813 |
Method for the determination of the enzymatic activity of convertase
The invention relates to a method for measuring the enzymatic activity of a convertase, wherein: (a) a biological sample containing the convertase is brought into contact with a labeled peptide...
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4879235 |
Process for producing protease by cultivating a protease-producing mold in a liquid medium
A process for producing protease by cultivating a protease-producing mold in a liquid medium, which is characterized by continuously adding a liquid medium containing a protein material to the...
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4870016 |
Process of chemical modfication of protides and the products thus modified
Process of modification of a protide by fixation of an organic group to its molecule, comprising reacting the protide with a dithioic acid, salt or ester, the acid residue of which comprises the...
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4859596 |
Cloning system for Kluyveromyces species
A new cloning system is described capable of expressing genetic material derived from recombinant DNA material, which comprises a yeast of the genus Kluyveromyces as a host. Suitable vectors are...
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4832849 |
Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
Applicant has isolated a Factor X a inhibiting substance from the salivary gland extract of the leech H.ghilianii. The extract is subjected to separation using both DEAE-cellulose and...
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4820811 |
Amine reacted therapeutic agents
A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R 1 and R 2 are the same or...
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4816400 |
Basement membrane collagen degrading enzyme and method of purifying same
Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.
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4808528 |
Antibody composition for the detection of malignant cells with metastatic cell activity
Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.
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4798791 |
Vector for high level gene expression
Methods and vectors for high level expression of genes in bacteria are disclosed. A terminal mRNA sequence from a gene coding for a stable bacterial protein mRNA is ligated to a gene coding for the...
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4797362 |
Alkaline proteases and microorganisms producing same
Novel microorganisms are provided which belong to the genus Bacillus and have ability of producing novel alkaline proteases. The alkaline proteases have excellent stability in highly alkaline...
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4788056 |
Combined vaccine for viral and bacterial infections
Vaccines containing both E.coli and herpes virus were found not to provide adequate protection against subsequent herpes virus infections. The present invention is concerned with a E.coli herpes...
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4788149 |
Proteolytic enzyme from blood-sucking nematodes and its uses as an anticoagulant as a vaccine and as an antithelminic agent
This invention relates to proteolytic enzymes with elastolytic properties from blood-sucking nematodes (hereinafter called HP enzymes). These enzymes are useful an anti-coagulants and as a means...
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4784950 |
Expression of factor VII activity in mammalian cells
Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably...
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4780412 |
Fibrinolytic enzymes produced from established non-cancerous cell lines
Fibrinolytic enzymes are produced and then isolated from non-cancerous established cell lines, designated as BEB or GPK. These fibrinolytic enzymes differ from those produced by malignant cell lines.
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4762789 |
Serodiagnostic reagent for entamoeba histolytica
The present invention is a composition of matter composed essentially of a purified homogeneous thiol proteinase secreted by Entamoeba histolytica trophozoites. In purified homogeneous form the...
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4757005 |
Method and cell line for obtaining plasminogen activators
A method of increasing the yield of plasminogen activator from a plasminogen activator-producing cell line by adapting said cell line to grow in a suitable growth medium essentially free of fetal...
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4751003 |
Crossflow microfiltration process for the separation of biotechnologically produced materials
The invention relates to a process for the separation of biotechnologically produced valuable materials form a cell suspension by crossflow microfiltration to obtain an high specific permeate flux...
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4749511 |
Contact lens cleaning solutions containing endoproteinase lys-C
Contact lens cleaning compositions and a method which comprises treating soft contact lenses with general purpose proteases in combination with endoproteinase lys-C are effective in dissolving away...
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4743551 |
Purification of microbial rennet from Mucor miehei
A method for the purification of a culture filtrate resulting from the fermentation of an organism of the species Mucor miehei involves the selective adsorption of the microbial rennet present in...
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4743550 |
Method for improving the partition coefficient in enzyme-containing systems having at least two phases
A process for the recovery of enzymes from an aqueous system having at least two aqueous phases wherein the partition coefficient with respect to an enzyme may be improved through the addition of...
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4740306 |
Chromatographic column
A chromatographic column and process for isolating or purifying steroid hormone or cell membrane receptors using the column are provided in which the column contains at least three resin layers...
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4738925 |
Method of increasing solubility of enzymes
A method is provided for increasing the solubility of an enzyme in an aqueous solution comprising providing a water-soluble anionic surfactant to the solution and further providing the solution...
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4737363 |
Bacteroides nodosus vaccine
A vaccine for use in the prevention or treatment of foot-rot comprises an immunologically effective amount of at least one protease, particularly an extracellular serine protease, of Bacteroides...
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4731327 |
Method for stabilizing recombinant DNA molecules and enhancing the expression thereof in strains of Bacillus
A recombinant DNA molecule, a portion of which includes a vector whose replication is initiated independently of the temperature-sensitive mutant gene of a temperature-sensitive mutant strain of...
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4725443 |
Meat tenderization with proteolytic enzyme-containing oil
Beef, fish and fowl are tenderized, without oozing out flavoring substances, by contacting with oil and/or fat containing a proteolytic enzyme. Preferably, contacting is by soaking in a composition...
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4710462 |
Cell proliferation inhibitor and method of preparation
This invention comprises preparing a cell proliferation inhibitor by a nonextractive method from a tissue which has neither a high content of collagen, nor proteoglycans. The source of inhibitor...
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4677069 |
Clam derived proteinases
This invention relates to three enzymes, their isolation from the viscera of bivalves, e.g. the surf clam or cherrystone clam, their characterization and uses. The first two are carboxyl...
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4673647 |
Process to solubilize enzymes and an enzyme liquid product produced thereby
This invention relates to a novel process for the recovery of enzymes obtained from enzyme-producing microorganisms, and to the liquid enzyme product recovered by this process. Typically, the...
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4672032 |
Dental enamel production
Methods are provided for the formation of dental enamel crystals in biosynthetic matrix form by the nucleation of calcium solutions with enamel proteins and for the use of such enamel crystals as...
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4661453 |
Production of tissue plasminogen activator factor
A process for the production of a tissue plasminogen activator obtained from cultured rat prostate adenocarcinoma cells. The techniques described lead to enhanced production of the tissue...
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4634671 |
Water-soluble cross-linked polymer of lysyl endopeptidase, process for preparing same and use of same
A water-soluble cross-linked polymer of the enzyme lysyl endopeptidase produced by Achromobacter lyticus and a process for preparing the polymer as well as a semi-synthesis of human insulin using...
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4591504 |
Human leucocyte pepsin-like enzyme as a therapeutic agent for treating allergic disorders and immune complex diseases
This invention provides a human leucocyte pepsin-like enzyme and a therapeutic agent and method for treating allergic disorders, immune complex diseases and tumors, the agent containing the enzyme...
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4585653 |
Neuraminidase treated ancrod
Disclosed is a pharmaceutically effective agent and method of use, comprising ancrod which has been incubated with neuraminidase. The neuraminidase-treated ancrod (NTA) can be substituted for...
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4581332 |
Novel alkaline protease
A novel protease is described. The enzyme has the following characteristics: molecular weight: 30,000 (a gel filtration method using Sephadex G-75); isoelectric point, 5.3; pH reactivity: the...
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4552760 |
Method for stabilizing tissue plasminogen activator and a stable aqueous solution or powder containing the same
A method for stabilizing a tissue plasminogen activator which involves adding to an aqueous solution or powder containing a tissue plasminogen activator an effective amount of a purified gelatin is...
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4532211 |
Coliform bacillus having a gene for the production of staphylokinase and a process for production of staphylokinase therewith
Novel coliform bacillus useful for industrial production of staphylokinase, a fibrinolytic enzyme, and process for the production of staphylokinase using said microbe are provided. The novel...
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4532212 |
Process for the dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous systems
Process for the dissolution of peptides and proteins in non-aqueous and mixed non-aqueous/aqueous solvents using crown ethers, solutions thereby obtained and their use. Purification of proteins...
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4515705 |
Compositions containing odor purified proteolytic enzymes and perfumes
Compositions containing proteolytic enzymes having no detectable odor at a concentration of less than about 0.002 Anson units per gram of distilled water, and selected perfume materials for...
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4511490 |
Cooperative enzymes comprising alkaline or mixtures of alkaline and neutral proteases without stabilizers
A stable, cooperative enzyme system which is stable under use conditions is disclosed which comprises at least two enzymes having activity towards a relatively complex substrate with at least...
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4510248 |
Process for concentrating and purifying human urinary kallikrein
Human urinary kallikrein is concentrated and purified by the following procedures; (a) Human urine is contacted with chitosan, a high molecular agglutinant obtained from chitin, at a pH from 4.0 to...
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4508825 |
Method for the separation of extracellular amylase and protease produced during the fermentation of enzyme producing microorganisms
Extracellular protease and amylase coproduced during the fermentation of a microorganism capable of producing them are separated by the addition of polyethyleneglycol and a cationic...
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4507389 |
Determination of collagenase by reacting with peptide substrates
Synthetic peptide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: R 1 -Pro-Leu-Gly-Leu-Leu-Gly-R 2 and R 1 ...
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4499065 |
Chymopapain allergen and method
A chymopapain derivative having the enzymatic activity reduced by at least 95% while retaining the original allergenic activity of at least 90% is suitable for skin testing to detect allergic...
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4482485 |
Method of preparation of human urine origin colony-stimulating factor and kallikrein
Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting...
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4461833 |
Chromatographically purifying proteolytic procoagulant enzyme from animal tissue extract
A chromatographic procedure for the purification of a proteolytic procoagulant enzyme from extracts of human and animal tumors. The extracts are sequentially contacted with a first benzamide...
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4442214 |
Thermo-stable micro-organism
The invention relates to an extremely thermophilic bacterium, THERMUS T-351, and a thermophilic protease, CALDOLYSIN, derived therefrom. The bacterium cells are Gram negative, non-sporulating rods....
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4414332 |
Endoproteinase-Lys-C and process for its preparation thereof
The present invention provides endoproteinase-Lys-C from bacteria, consisting of a chain of molecular weight 35000 to 38000 Dalton, having a pH optimum at pH 7.7 and being inhibited by aprotinin...
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4393139 |
Process for the selective separation of endoproteases
The present invention provides a process for the selective separation of endoproteases from aqueous solutions, wherein an aqueous solution containing proteases is treated with a complex, present in...
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