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8183007 |
ADP detection based methods using adenylate cyclase and bioluminescence
The disclosure provides compositions and methods to determine or detect ADP or the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and...
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8153436 |
Assays for disease-associated crystals in biological samples
Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging...
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8137956 |
Forensic test strip and method for the detection of semen
The present invention relates to a forensic test strip and method for the detection of semen. This strip is comprised of a paper element coated with reagents which react to the presence of acid...
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8097431 |
Methods and compositions for detecting steroids
The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof....
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8093014 |
Kit for detecting and measuring element tagged kinases and phosphatases by inductively coupled plasma mass spectrometry
Kits for the assay of enzymes involved in post-translational modifications are provided. The kits facilitate the execution of methods of assay that allow for convenient and accurate analysis using...
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8067536 |
Kinase and phosphatase assays
Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a...
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8039229 |
Identification of toxin-binding protein involved in resistance to Cry1 toxins, and related screening methods
The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to Bacillus thuringiensis Cry toxins have measurably altered alkaline phosphatase...
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8008035 |
Enhancement of vanadium-containing phosphatase inhibitors
The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even...
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7939289 |
Distinction method for the catch capacity of proteins
A distinction method is provided to distinguish catch capacity where myosin, a protein that constitutes muscles, or filaments containing myosin bind to actin due to the contribution of twitchin...
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7935493 |
Protein fragment complementation assays for high-throughput and high-content screening
The present invention provides protein fragment complementation assays for drug discovery, in particular to identify compounds that activate or inhibit cellular pathways. Based on the selection of...
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7927872 |
ALDOs as modifiers of the IGF pathway and methods of use
Human ALDO genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF,...
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7901901 |
Assays for measuring phosphate modification enzyme activity
The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays...
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7892777 |
Methods for measuring whether a treatment affects RPTP-κ activity
Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation ...
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7868147 |
Fluorescent probe
A fluorescent probe which is represented by the following formula (I): (wherein, R1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R2 represents...
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7824880 |
High sensitivity assay for detection of nucleoside diphosphate production
The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as...
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7807400 |
Methods for identifying chemical modulators of Ras superfamily GTPase activity
The present invention provides a method of identifying a compound having the ability to modulate the guanine nucleotide exchange cycle of a Ras superfamily GTPase, comprising: a) contacting the...
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7807399 |
Methods for detecting thiol-containing nucleotide diphosphates with thiol-reactive fluorescent reagents
Disclosed are methods for detecting thiol-containing nucleotide diphosphates. The methods utilize thiol-reactive fluorescent reagents.
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7807864 |
Transgenic animal as a model for fibrotic diseases
Disclosed is a transgenic non-human animal with broad or cell type-specific ectopic expression of fra-2 that manifests itself in a fibrotic disease, methods for obtaining such animal and their use....
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7794965 |
Method of identifying modulators of PP2A methylase
The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect...
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7781182 |
Ubiquitin ligase assay
The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
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7763441 |
Modulators of gluconeogenesis
The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of...
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7745165 |
Phosphatase associated with metastasis
Among the genes identified, in a comparison of the global gene expression profile of metastatic colorectal cancer to that of primary cancers, benign colorectal tumors, and normal colorectal...
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7736911 |
Activity-based probes for protein tyrosine phosphatases
Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds...
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7687464 |
Method for activating T cell protein tyrosine phosphatase for therapeutic applications
This invention relates to methods for activation of T cell protein tyrosine phosphatase (TCPTP) and for inhibiting tyrosine kinase signalling in an individual. The invention concerns a method for...
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7674600 |
Assays for measuring phosphate modification enzyme activity
The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays...
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7642064 |
Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte...
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7632651 |
Molecular modification assays
Systems for detecting molecular modifications and the presence and/or activity of enzymes and/or other agents involved in facilitating or otherwise regulating such modifications.
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7585643 |
Method for detecting kinase activity with thiol reactive fluorescent reagents
Disclosed are assays useful for detecting kinase activity. The assays utilize thiol-reactive fluorescent reagents and include reacting a reaction mixture that contains an ATP analog such as ATPβS ...
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7566550 |
Screening method for developing drugs against pathogenic microbes having two-component system
The present invention relates to a package of screening methods for developing drugs against pathogenic microbes having two-component system of DevR-DevS and/or DevR-Rv2027c and its homologues,...
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7524642 |
Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying...
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7494784 |
Method of treating cell-migration conditions or diseases
The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or ...
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7465556 |
Method of immunoassay tartrate resistant acid phosphatase 5b and kit to be used therein
Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b...
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7449304 |
Method for enhancing the efficiency of an enzymatic process for removal of contaminating nucleotides
This invention relates to methods for enhancing the efficiency of biological processes that involve successive enzymatic reactions. More specifically, the invention relates to methods for enhancing...
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7442398 |
Phytase produced from Citrobacter braakii
The present invention relates to phytase enzyme, a gene encoding the enzyme, and a Citrobacter sp. producing the enzyme. Particularly, the present invention relates to the phytase enzyme produced...
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7435572 |
Methods and compositions for DNA manipulation
Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition....
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7432070 |
Homogenous assay for enzymatic activity
An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a...
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7427485 |
Method for classification of anti-psychotic drugs
The present invention provides a method for identifying an agent to be tested for an ability to treat a psychotic disorder in a patient in need of such treatment. The invention provides a method...
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7422845 |
Detection of NO by using guanylyl cyclase and cGMP production as a readout system
The present invention relates to a method for determining NO enzymatically and its use for the identification of substances which can modulate a nitric oxide synthase activity.
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7416856 |
High sensitivity assay for detection of nucleoside diphosphate production
The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as...
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7416703 |
Polymer based lanthanide luminescent sensors for the detection of organophosphorus compounds
A device for measuring and detecting the organophosphonis compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to...
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7407783 |
Fructosylamine oxidase
The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum, and purifying two types of fructosylamine oxidase (FAO) with different substrate...
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7402406 |
Methods of evaluating phosphatase inhibitors
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using...
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7396658 |
Methods for screening HIF like ouabain-resistant Na+—K+-ATPase agents
The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+—K+-ATPase i...
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7384761 |
Methods of identifying an agent capable of interfering with Rad9 dephosphorylation
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host...
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7378254 |
Compositions and assays utilizing ADP or phosphate for detecting protein modulators
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods...
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7374900 |
Fluorescent substrates for detecting organophosphatase enzyme activity
Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2,...
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7374899 |
Sucrose-6-phosphate phosphatase as target for herbicides
The present invention relates to the use of a polypeptide with the biological activity of a sucrose-6-phosphate phosphatase which, if not present, brings about growth retardation symptoms and...
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7371537 |
Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte...
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7364843 |
Method of identifying target cell using target cell-specific virus
Provided is a method of identifying a target cell using a virus. The method includes infecting the target cell with the virus by contacting the virus to the target cell and culturing the target...
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