|
Match
|
Document |
Document Title |
|
|
4952495 |
Hydrolyzable compounds which release electron transfer agents and analytical use of same
Hydrolyzable substrates comprise blocked moieties which, when cleaved from the substrate during hydrolysis, provide electron transfer agents. The released electron transfer agents can be recycled...
|
|
|
4948726 |
Enzyme immunoassay based on membrane separation of antigen-antibody complexes
An enzyme immunoassay based on membrane separation of antigen-antibody complexes wherein human or animal body fluid specimens containing an antigen are mixed with an enzyme-conjugated antibody...
|
|
|
4946776 |
Stable chromogenic substrate mixture of indoxyl phosphate and tetrazolium salt, method of making and using same in biological and diagnostic assays
A stable chromogenic substrate mixture of indoxyl phosphate and tetrazolium salt is prepared by dissolving the phosphate in DMF and combining the same with Tris buffer containing magnesium chloride...
|
|
|
4933278 |
Method of determining the number of cells in cell culture
A method is disclosed for determining the number of cells in cell culture which comprises lysing the cells and incubating the cell lysate with p-nitrophenyl phosphate for a predetermined period of...
|
|
|
4921786 |
Novel NAD synthetase, assay method using said novel NAD synthetase and a process for production thereof
A novel NAD synthetase is produced by culturing a broth of Bacillus stearothermophilus H-804 FERM BP-1408. This new enzyme selectively catalyzes the reaction ##STR1## without catalyzing the...
|
|
|
4914025 |
Export of intra-cellular substances
An export sequence of export DNA can be identified by transforming a population of cells with a vector having a transposon that includes a structural gene encoding a detectable compound, positioned...
|
|
|
4914023 |
Method of extending the linear range of an enzyme immunoassay by measuring off-peak absorbance
The present invention relates to enzyme immunoassays employing one or more enzyme label-substrate pairs which give rise to colored products and in which absorption by the product of substrate...
|
|
|
4908306 |
Human papillomavirus 56 nucleic acid hybridization probes and methods for employing the same
Nucleic acid hybridization probes for human papillomavirus types and particularly human papillomavirus type 56; and methods for employing the same.
|
|
|
4904583 |
Cascade immunoassay by multiple binding reactions
A method for enzyme immunoassay includes contacting under binding conditions a liquid suspected of containing an analyte, an antianalyte affixed to a solid support and a tracer having an enzyme...
|
|
|
4900665 |
Integral multilayer analytical element for use in the measurement of alkaline phosphatase activity
An integral multilayer analytical element for use in the measurement of alkaline phosphatase activity, which comprises a porous spreading layer of woven fabric or knitted fabric containing an...
|
|
|
4892817 |
Stable phosphatase substrate composition
A stabilized phosphatase substrate composition is provided comprising an indoxl phosphate, a tetrazolium salt, and a water-soluble ferricyanide/ferrocyanide salt. When present as a solution, the...
|
|
|
4889799 |
Reagent kit producing shortened target DNA segments usable in sequencing large DNA segments
A process is provided for producing an ordered series of cloned, circular, DNA molecules containing shortened target DNA segments derived from a long target DNA segment, which are suitable for use...
|
|
|
4888288 |
Vesicles resistant to enzyme lysis and use thereof in an enzyme assay
Liposomes are formed from compounds including a phosphonate or phosphinate group instead of a phosphate group. The liposomes bind to enzymes, such as a phospholipase, and such liposomes containing...
|
|
|
4886741 |
Use of volume exclusion agents for the enhancement of in situ hybridization
This invention relates to methods for using volume exclusion agents to enhance in situ hybridization rates between short oligonucleotide probes and their target polynucleotides where the cells...
|
|
|
4882423 |
Substance-conjugated complement component C1q
A substance-conjugated complement component Clq is provided. A substance such as signal emitting substances or cell function regulating substances is conjugated via a sulfur atom to at least one...
|
|
|
4879218 |
Antibody for C.difficile
Monoclonal antibody to toxin A of C.difficile has been prepared and is used in an assay for toxin A of C.difficile.
|
|
|
4861709 |
Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
A method for determining the presence of microorganisms in a tests sample. Exogenous DNA containing a luminescent system or other genetic marker system derived from a suitable donor source is...
|
|
|
4855227 |
Rapid detection of mycoplasmas
A clinical diagnostic method capable of rapidly detecting the presence of Mycoplasma pneumoniae in infected humans is taught. The method allows a proper course of therapy to be chosen within one...
|
|
|
4849332 |
Human papillomavirus 35 nucleic acid hybridization probes and methods for employing the same
Nucleic acid hybridization probes for human papillomavirus types and particularly human papillomavirus type 35; and methods for employing the same.
|
|
|
4849337 |
Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
A method for identifying and quantifying allergen specific IgE levels in patent serum by conjugating the IgE in the serum with allergens adhering to an insoluble support, conjugating the serum IgE...
|
|
|
4849335 |
Method for detecting the mutagenicity of substances susceptible of inducing the deterioration of cellular DNA, utilizing the production of an SOS response
A method for the detection of the mutagen effect of a substance or composition by producing culture of a micro-organism harboring a recombinant of a sfi gene and of a gene coding for a dosable...
|
|
|
4849331 |
Human papillomavirus 44 nucleic acid hybridization probes and methods for employing the same
Nucleic acid hybridization probes for human papillomavirus types and particularly human papillomavirus type 44; and methods for employing the same.
|
|
|
4849334 |
Human papillomavirus 43 nucleic acid hybridization probes and methods for employing the same
Nucleic acid hybridization probes for human papillomavirus types and particularly human papillomavirus type 43; and methods for employing the same.
|
|
|
4845028 |
Composition for lipase assay
A composition and method for lipase assay, comprising the use of an aqueous solution of a 1,2-diglyceride of a higher fatty acid, and a nonionic surface active agent. The higher fatty acid is a...
|
|
|
4845027 |
Fluorometric assay of allergic reactions
A method for identifying and quantifying allergen specific IgE levels in patient serum by conjugating the serum IgE with allergens on an insoluble support, conjugating the serum IgE with an enzyme...
|
|
|
4844966 |
Assaying total IgE levels with fluorogenic enzyme labeled antibody
A method for identifying and quantifying total IgE levels in patient serum by conjugating the IgE in the serum with anti-IgE antibody adhering to an insoluble support, conjugating the serum IgE...
|
|
|
4840895 |
Monoclonal antibodies reactive with immune complexes
A secondary monoclonal antibody against a complex of a molecule of molecular weight less than 5000 and a binding protein against said molecule which secondary monoclonal antibody is not an antibody...
|
|
|
4835099 |
Signal enhancement in immunoassay by modulation of enzymatic catalysis
A method for enzyme immunoassay for a ligand suspected to be present in a liquid sample includes signal amplification by use of at least two hydrolases and a blocked fluoroketone for one of the...
|
|
|
4830960 |
Determination of chlamydia trachomatis
A process for determining qualitatively or quantitatively the presence of Chlamydia Trachomatis or Chlamydia trachomatis derived material in a subject material which process comprises deriving a...
|
|
|
4830959 |
Electrochemical enzymic assay procedures
Electrochemical detection of mediator level is employed in a method of assay using a redox enzyme and redox substrate to detect conversion to an effective mediator by an assay enzyme label of a...
|
|
|
4828982 |
Vesticles and use thereof in an enzyme assay
A sac is produced by use of a compound which includes a hydrophobic portion and a polar group which is hydrolyzable by an enzyme and which is spaced from the hydrophobic portion by a hydrophilic...
|
|
|
4828985 |
Antibodies against the complex of a small molecule and its binding protein, their preparation and their use in diagnostic methods
The invention involves polyclonal antibodies reactive with a complex of a hapten and its binding protein, wherein the antibodies are unreactive with the free hapten or free binding protein. The...
|
|
|
4820627 |
Method of preparing particles suitable for tabletting into diagnostic reagents
A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an...
|
|
|
4812400 |
Process for measuring sodium levels in biological fluids
A process for measuring the sodium concentration of a biological fluid, such as blood serum or urine, is carried out by fixing the amounts of adenosine-5'-triphosphate (ATP), adenosine...
|
|
|
4812396 |
Method for detecting enzymatic activity using particle agglutination
A method is disclosed for determining enzymatic activity in a liquid sample by particle agglutination or inhibition of particle agglutination.
|
|
|
4810636 |
Chromogenic acridinone enzyme substrates
Chromogenic acridinone enzyme substrate compounds comprising 7-hydroxy-9H-acridin-2-one chromogens derivatized at the 7-hydroxy-position with an enzymatically-cleavable group and disubstituted at...
|
|
|
4810631 |
Signal enhancement in immunoassay by modulation of chemical catalysis
A method for immunoassay for a ligand suspected to be present in a fluid includes use of an enzyme, a metal ion catalyst for an indicator reaction and a blocked modulator for the catalyst. Ligand...
|
|
|
4808522 |
Enzyme immunoassays using inorganic pyrophosphatase
A method for determination of an antigen, which comprises preparation of a onjugate by way of cross-linking of an antibody with an inorganic pyrophosphatase, reacting the resulting conjugate with...
|
|
|
4806415 |
Method and system for determining the presence of adenosine triphosphate or flavin mononucleotide
An enzymatic determination of one of the co-enzymes adenosine triphosphate (ATP) or flavin mono-nucleotide (FMN) based on the use of an flavine adenine dinucleotide (FAD) synthetase-active system...
|
|
|
4806470 |
Analytical element and method for theophylline determination having increased alkaline phosphatase isoenzyme
Theophylline can be determined with an analytical element and method which utilize the inhibition, by theophylline, of alkaline phosphatase activity on an appropriate substrate. The assay is...
|
|
|
4803157 |
Hydrolyzable fluorescent substrates for phosphatases and analytical use thereof
Hydrolyzable substrates for acid and alkaline phosphatases comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum...
|
|
|
4795701 |
Homogeneous polynucleotide displacement assay method kit and reagent complex
An RNA signal strand is displaced from a probe strand by a target nucleotide sequence. Without separation, a digestion enzyme selective for displaced RNA, e.g., a polynucleotide phosphorylase,...
|
|
|
4788143 |
Method for determining levels of cell-mediated immunity
A patient's level of cell-mediated immunity is determined by obtaining a blood sample from the patient, incubating cells from the sample in a tissue culture medium containing Concanavalin A, and...
|
|
|
4782017 |
Analytical element and method for determination of theophylline by enzyme inhibition
Theophylline can be determined with an analytical element and method which utilize the inhibition, by theophylline, of alkaline phosphatase activity on an appropriate substrate. The assay is...
|
|
|
4782016 |
Analytical element and method for determination of theophylline by enzyme inhibition
Theophylline can be determined with an analytical element, composition, kit and method which utilize the inhibition, by theophylline, of alkaline phosphatase activity on an appropriate substrate....
|
|
|
4778755 |
Immunoassay method
In the determination of the quantity of enzyme present as a result of an immunoassay procedure, the enzyme containing component is combined with a substrate which in the presence of the enzyme...
|
|
|
4774177 |
Immunoassay method for detection of antibodies and antigens
A method for detecting the presence of antibody or antigen in a liquid sample suspected of containing the antibody or antigen. To a test panel comprising a nitrocellulose carrier having stably...
|
|
|
4770996 |
Identification of individuals predisposed toward alcohol abuse
A method and an assay for ascertaining individuals likely to be predisposed to alcohol abuse is disclosed. The contemplated method ascertains the relative adenylate cyclase and monoamine oxidase...
|
|
|
4769321 |
Assay method and reagent therefor
Enzymatic assays are described which enable the detection of inter alia enzymes, cofactors and substrates in small quantity with the ability to produce a visually detectable change.
|
|
|
4748115 |
Substrate formulation in 2-amino-2-methyl-1-propanol buffer for alkaline phosphatase assays
A stable substrate formulation for an alkaline phosphatase assay includes 5-bromo-4-chloro-3-indolyl phosphate, nitro blue tetrazolium and a 2-amino-2-methyl-1-propanol buffer. Addition of MgCl2 to...
|