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7582426 |
Method for expression of proteins on spore surface
The present invention relates to a method for display of proteinson spore surface and a method for improving protein with rapidity using the same, which comprises the steps of (i) preparing a...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7393672 |
DNA coding for endo-β-galactosidase
A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7291474 |
Hydrolytic substrates for an analyte-dependent enzyme activation system
Disclosed are compounds of the general formulas:
wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is...
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7179634 |
Methods for producing a polypeptide in a Bacillus cell
The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a Bacillus host cell in a medium conducive for the production of the polypeptide, wherein the ...
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7135325 |
Short enzyme donor fragment
Short enzyme donor fragments of β-galactosidase are provided of not more than 40 amino acids, where the short fragments are used as a label and may be substituted with a wide variety of organic...
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7105330 |
Human plasma hyaluronidase
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7060483 |
DNA encoding endo-β-galactosidase
A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of...
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6933126 |
Membrane transportable fluorescent substrates
Intracellular enzyme-activated fluorescent substrates that can be transported into a cell are provided. The membrane transportable fluorescent substrates are complexes (e.g., ionic complexes)...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6846656 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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6838271 |
Low temperature expression chitinase cDNAs and method for isolating the same
A winter wheat-derived chitinase cDNA is provided which has a nucleotide sequence corresponding to an amino acid sequence listed as SEQ. ID. No.1 in FIG. 1 . Another winter wheat-derived chitinase...
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6838239 |
Chitobiase as a reporter enzyme
The present invention relates to reporter gene constructs encoding a cytoplasmic form of chitobiase (N,N′-diacetylchitobiase) and methods of using these reporter gene constructs. The use of a...
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6833260 |
Lactose hydrolysis
The invention features methods and compositions for rapidly and effectively hydrolyzing lactose using recombinant lactic acid bacteria.
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6767728 |
Composition for enzymatic deinking of waste paper
A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme...
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6727084 |
Cold-active beta-galactosidase, the process for its preparation and the use thereof
A purified cold-active beta galactosidase enzyme, specific for lactose, having a stable enzymatic activity at a temperature below 8° C. In the presence of lactose, a purified cold-active beta...
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6677137 |
Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity
Avian and reptile derived heparanase and nucleic acids encoding same.
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6653109 |
Method of producing derivatives of lactosamine
Disclosed is a method of producing a compound with β1-4 linkage which contains the lactosamine structure involving reacting at least one donor substance GalβOR where R is an organic group, and at...
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6605431 |
Promoter elements and methods of use
The present invention provides novel polynucleotides that include promoter elements. The present invention also provides methods and kits for identification of compounds that alter transcription,...
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6573076 |
Gene, group of genes, and novel β-glucosidase
An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms. The present invention relates to a gene group encoding cellulase,...
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6566099 |
Nucleic acid encoding a chimeric polypeptide
A therapeutic method whereby an individual suspected of having an α-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to...
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6541233 |
β-glucanase from a bacillus
A β-Glucanase enzyme capable of hydrolytically cleaving mixed glucans is presented. The β-Glucanase is sufficiently stable under alkaline conditions for use in industrial cleaning processes,...
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6534632 |
Sialidase localized in plasma membrane DNA coding for the same
The present invention provides a protein defined in the following (A) or (B), and DNA coding for the same: (A) a protein which has the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or (B) a...
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6511838 |
Genes coding for β-agarases and their use for producing agar biodegradation enzymes
The invention relates to the novel Cytophaga drobachiensis strain deposited in the DSMZ Collection (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (German Collection of...
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6506592 |
Hyperthermophilic alpha-glucosidase gene and its use
Recombinant, thermostable alpha-glucosidases from archaeal micro-organisms and isolated DNA encoding for such alpha-glucosidases are provided. The isolated DNA is obtained by use of DNA or antibody...
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6461837 |
Methods for producing a polypeptide using a consensus translational initiator sequence
The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal...
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6358724 |
Isolation and composition of novel glycosidases
Substantially pure glycosidases capable for cleaving selected glycosidic bonds have been described including glycosidases isolated from Xanthomonas and recombinant glycosidases. Substrate...
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6316251 |
Gene, group of genes, and novel β-gluclosidase
An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms. The present invention relates to a gene group encoding cellulase,...
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6274565 |
Inhibitor of activation of β-glucan recognition protein
The present invention relates to an inhibitor of an activation of β-glucan recognition protein in a body fluid of an insect comprising a sugar compound comprising plural member of sugar residues,...
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6248574 |
Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides
Highly conserved polypeptide sequences derived from gp41 and gp120, preferably from eleven to twenty-one amino acids in length, are joined (for example, via DNA recombinant techniques) to a non-HIV...
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6140115 |
Canine β-galactosidase gene and GM1-gangliosidosis
The acid β-galactosidase cDNA of Portuguese Water (PW) dogs was isolated and sequenced. The entire encoding region of the gene consists of 2004 nucleotides coding a protein of 668 amino acids. Its...
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6106872 |
Process for obtaining aroma components and aromas from their precursors of a glycosidic nature, and aroma components and aromas thereby obtained
An enzymatic hydrolysis of a glycosidic substrate containing at least one of the said precursors is performed with at least one enzyme chosen in accordance with the structure of the said precursor,...
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6057139 |
Preblend of microcrystalline cellulose and lactase for making tablets
A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose....
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6043075 |
Endoglucanase
An endoglucanase obtainable from Dictyoglomus exhibiting optimum activity at a temperature above 85° C. is disclosed.
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6037145 |
Process for production of protein
A process for the production of a desired polypeptide comprising the steps of: (1) transforming host cells with an expression vector comprising a gene coding for a fusion protein comprising a...
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6001636 |
Isolated agarase enzyme from flavobacterium SP. strain NR19, cloned genes therefor, and expression thereof in transformed host cells
Novel purified agarase enzymes from Flavobacterium sp. strain NR19 and cloned genes encoding the agarase enzymes are disclosed. Transformed host cells which express the novel agarase enzymes in...
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5976857 |
Cross-linked polypeptide fragments of β-galactosidase
Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of β-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme...
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5962326 |
Hyperthermostable β-galactosidase gene, enzyme encoded thereby, and process for production
An isolated SDS-resistant hyperthermostable β-galactosidase gene derived from Pyrococcus furiosus. Examples thereof include genes respectively shown in SEQ ID NO: 1 and SEQ ID NO: 2 and genes each...
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5958676 |
Genetically engineered cell lines for detecting infectious herpesvirus and methods therefor
A diagnostic assay for detecting the presence of an infectious herpesvirus in a specimen and a genetically engineered cell line for use in such assay are disclosed. The cell line used in the assay...
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5891669 |
Methods for producing polypeptides in respiratory-deficient cells
The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which...
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5876981 |
Transglycosylation reactions employing β-galactosidase
β-Galactosides are synthesized using a transglycosylation reaction catalyzed by β-galactosidase. The reaction employs a carbohydrate donor having a glycosidic leaving group attached to its...
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5830673 |
Bioassay of selenium
The invention relates to a plasmid carrying a selenium-specifying DNA seqce of the E. coli fdhF gene upstream of the E. coli lac'Z gene which permits the incorporation of selenocystein into...
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5827552 |
Production of fermented food products
This invention discloses novel methods of making fermented food products such as yogurt. It also discloses novel Lactobacillus bulgaricus organisms for making fermented food products which are...
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5795728 |
Biomarkers of cell senescence
The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, β-galactosidase activity is utilized as a...
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5766914 |
Method of producing and purifying enzymes
A method of producing and purifying an enzyme which comprises selecting a spore forming host organism, preparing a genetic construct consisting of a DNA sequence encoding the desired enzyme and a...
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5736374 |
Increased production of β-galactosidase in aspergillus oryzae
Novel methods are disclosed for the enhanced expression and secretion of lactase from filamentous fungi. Specifically the novel processes cause enhanced production of lactase from an Aspergillus...
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5707843 |
Lactose enzyme compositions and method
A chemically commercially sterilized enzyme composition for addition to a pasteurized dairy product to reduce gradually the lactose content of the dairy product and to introduce functioning enzymes...
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5674678 |
Process for controlling cultures of recombinants
Expression of a desired gene and production of a product from the desired gene can be obtained effectively by cultivating a microorganism containing a hybrid plasmid comprising the desired gene, a...
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