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7083909 |
Composition containing gamete or embryo and animal white yolk and the use thereof
A composition that contains a gamete or an embryo and animal white yolk is disclosed. Also disclosed are applications of the composition.
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7070918 |
Method for enhancement of sperm survival using soluble peripheral protein fraction of APM
A method of improving and/or prolonging sperm viability which comprises contacting spermatozoa with an isolated, cell-free protein fraction of oviductal apical plasma membrane (APM). This finds use...
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7070917 |
Determination of sperm concentration and viability for artificial insemination
A method for the simultaneous determination of the total concentration of sperm cells and the proportion of live sperm cells in a semen sample is provided. By selective staining of live, dead...
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7060453 |
Method and kit for the determination of analyte concentration in blood
A method is provided for determining the level of an analyte in the blood of an individual based on determination of the level of the same analyte in non-blood sample (e.g. urine, saliva and hair)...
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7056657 |
Apparatus and methods for magnetic separation
Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface,...
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7056504 |
Rationally designed heparinases derived from heparinase I and II
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the...
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7056722 |
Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component...
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7052859 |
MUCIN 4 expression as a marker for pancreatic cancer
Methods are provided for the diagnosis of pancreatic cancer.
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7045148 |
Method of collecting placental stem cells
A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out...
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7038041 |
Selective nuclear receptor-targeted systems for delivery of cytotoxins to cancer cells for targeted photodynamic therapy
An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti...
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7037642 |
Removing compounds from blood products with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7029840 |
Method for preservation of cells and nucleic acid targets
The present invention provides a method for preserving cells and nucleic acids in a sample by exposing the sample to a composition that causes an inhibitory affect on proteolytic agents and/or...
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7026110 |
Reagent for determination of leucocytes and measurement of haemoglobin in a sample of blood
The invention concerns a reagent for determination of leucocytes and measurement of haemoglobin in a sample of blood. This reagent comprises a buffer system that is suited to adjust selectively the...
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7026132 |
Method of monitoring the effect of Cathepsin S inhibitors
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7015034 |
Materials and procedures for the purification of cells
The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can...
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7011938 |
Method of measuring platelet activation
Platelet activation is measured by determining Mean Platelet Component (MPC) of suspended blood platelets, using a specific anticoagulant composition. The composition comprises at least one...
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7001715 |
Purification of red blood cells by separation and diafiltration
Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent...
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6991787 |
Methods of preparing bone marrow stromal cells for use in gene therapy
This invention relates to sequential methods of cryopreserving bone marrow stromal cells that are transfected and used for gene therapy by transplantation. These methods include the following steps...
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6986984 |
Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to...
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6983884 |
Method and apparatus for monitoring transfusion of blood
Method and apparatus are described for ensuring that blood transfused into a patient is the correct blood for that patient, and that a complete audit trail is created that will allow later tracing...
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6984526 |
Spectrophotometric method for determining the viability of a sample containing platelets
A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined...
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6982172 |
Oocyte vitrification technique
A new method of cryopreservation based on the very fast cooling rates achieved by the direct contact of small droplets of vitrification solution containing biological sample with a very cold solid...
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6964771 |
Method for stably incorporating substances within dry, foamed glass matrices
The invention provides methods for producing foamed glass and the compositions obtained thereby. The compositions are suitable for stable storage of a wide variety of substances, particularly...
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6960446 |
Method for isolating cells expressing flk-2
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also...
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6960428 |
Storage and maintenance of platelets
Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of...
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6955889 |
Simultaneous determination of forward and reverse ABO blood group
Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be...
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6951713 |
Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the...
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6951839 |
Methods and compositions for regulating lymphocyte activity
The present application is directed to the discovery that hedgehog gene products, and signal transduction pathways involving hedgehog, are involved in maturation of T lymphocytes. Certain aspects...
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6946260 |
Allergen/inflammatory testing and diagnosis
The invention relates to the use of a secretor variant cell-line expressing the alpha moiety of human IgE binding protein to determine the allergic status of a given individual. Moreover, the...
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6946241 |
Physiological medium for perfusing, preserving and storing isolated cell, tissue and organ samples
A physiological liquid medium is provided having the basic, synergistic components to allow its universal application in preserving cellular and functional integrity in vitro of different cell,...
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6946242 |
Method for maintaining the viability of sperm
A rocker for extended, refrigerated storage or transport of fish sperm comprising a platform for sperm containers, drive mechanism, a power supply with an on/off switch or rheostat, and water...
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6946127 |
Decorated red blood cells
Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure...
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6946098 |
Methods for sterilizing biological materials
Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known...
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6942879 |
Bioartificial filtration device for filtering blood to mimic kidney function
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any...
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6936413 |
Methods and systems for preparing blood products
Methods and systems for preparing blood products that are ready for treatment in established pathogen inactivation procedures are disclosed. The methods include providing a source of a blood...
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6921667 |
Methods for direct detection of individual methotrexate metabolites
The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a...
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6921633 |
Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
The invention provides methods for the hypothermic preservation of cells, tissues and organs. In particular, the invention provides methods for the hypothermic preservation or storage of cells,...
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6921665 |
Selective antibody targeting of undifferentiated stem cells
This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector...
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6919206 |
Medium containing flt3 ligand for culturing hematophoietic cells
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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6919172 |
Preservation and storage medium for biological materials
A protectant mixture for use in preserving biological materials comprising (1) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the mixture is from about 5% to...
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6916658 |
Method for measurement of immature granulocytes
A method for measuring immature granulocytes in a blood sample is described. The method includes the steps of lysing red blood cells of a blood sample with a lytic reagent, analyzing the sample...
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6911313 |
Process for discriminating and counting erythroblasts
A method for discriminating and counting erythroblasts comprises the steps of: (i) staining leukocytes in a hematologic sample by adding a fluorescent labeled antibody capable of binding...
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6908591 |
Methods for sterilizing biological materials by irradiation over a temperature gradient
Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular...
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6905612 |
Plasma concentrate apparatus and method
A plasma concentrator for producing plasma concentrate from a plasma from which erythrocytes have been substantially removed. The device comprises a concentrating chamber having an inlet port and...
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6902931 |
Controlled reversible poration for preservation of biological materials
A preservation method for biological material having cell membranes includes reversibly porating the cell membranes; loading a bio-protective agent having bio-preservation properties to a...
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6900029 |
Method of selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation
A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have...
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6900023 |
Method for classifying and counting leukocytes
A method for classifying and counting leukocytes comprises the steps of: (1) adding to a hematological sample the following fluorescence-labeled antibodies labeled with fluorescent dyes which emit...
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6893823 |
Polynucleotide separation method and apparatus therefor
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
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6893881 |
Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell...
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