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6127187 |
Apparatus and method for analyzing blood samples
Apparatus for analyzing blood or the like has a centrifuge rotor (10) with a means for visibly holding a sample, and a scanning arm (32) which traverses the rotor and includes a means (38) for...
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6127111 |
Lyophilized platelet composition containing chloroquine, hydroxychloroquine, camoquin, quinacrine or procaine
The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a...
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6126835 |
Device and method for magnetic separation of biological molecules
Provided is a magnetic separation device comprising a container having one or more outer surfaces; at least one magnetic sheet; and a physical coupler that is used to detachably secure the...
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6124088 |
Method of permanent removal from cell suspension in a porous container
A process and apparatus in which cryoprotectant in cryopreserved samples is removed with the use of turbulence and convective-dispersion around the cells within the primary cryopreservation...
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6124087 |
Method of diagnosing a malignant disorder or its precursor stages
In a method of diagnosing a malignant disorder or its precursor stage, the percentage parts N i of blood cells in a size range of i=6 μm to i=16 μm in two blood samples of a patient, an arterial...
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6124101 |
Recombinant thrombin receptor and related pharmaceuticals
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at...
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6121055 |
Methods and devices for conducting specific binding assays
The invention provides methods for separating bound label from unbound label within an assay mixture, for predispensing assay reactants in self-contained assay vessels, as well as for detecting the...
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6120735 |
Fractional cell sorter
A method and apparatus for the fraction sorting of cells is provided. The invention include a dispensing device, aspirating device, flow channel and a magnetic assembly. A first fractional sorting...
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6121044 |
Potent antigen presenting cell composition
A method of obtaining a blood-cell fraction enriched for potent antigen presenting cells is disclosed. The method includes obtaining a monocyte-depleted lymphocyte fraction, culturing the cell...
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6114107 |
Composition comprising raffinose, TMAO, sodium citrate and methods for the preservation of living tissues
The present invention provides solutions and methods for preserving biological material that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of...
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6114173 |
Fully automated method and reagent composition therefor for rapid identification and characterization of reticulocytes erythrocytes and platelets in whole blood
The invention provides a very fast and reliable method and reagent composition for determining reticulocyte and erythrocyte counts, identification and characterization, as well as platelet counts,...
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6114108 |
Methods and compositions for the selective modification of viral nucleic acids
The means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions comprising contacting such compositions with selective ethyleneimine...
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6099740 |
Apparatus and methods for preparing blood or plasma component solutions of known concentration
An apparatus for separating a blood component, e.g., fibrin monomer, from blood or plasma comprises a container (110) with a reaction chamber for receiving the plasma, where said reaction chamber...
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6093559 |
Producing low binding hydrophobic surfaces by treating with a low HLB number non-ionic surfactant
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm 2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent...
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6090599 |
Viral inactivation treatment of red blood cells using phthalocyanines and red light
Disclosed are two processes. The first process involves treating a red blood cell-containing composition to inactivate an extracellular or intracellular virus which may be present in said red blood...
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6087087 |
Treatment of hemoglobin with nitric oxide
Methods and compositions are provided for treating diluents (including whole blood or at least one blood component) comprising hemoglobin containing erythrocytes (i.e., red blood cells), in order...
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6084074 |
Stabilized aqueous liquid preparations of blood coagulation factor XIII
A stabilized aqueous liquid preparation of human blood coagulation factor XIII, prepared by recombinant DNA technology, from the group consisting of galactose, sucrose, sorbitol, glutamate,...
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6083747 |
Method of preparing hematopoietic stem cells with gp105-specific antibodies
An N-glycosylated glycoprotein, having the molecular weight of 105 kDa when glycosylated and 85 kDa when non-glycosylated, is present on the surface of BL3 hematopoietic stem cells, but is absent...
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6080538 |
Plasma like solution and methods of use
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6077447 |
Fibrinogen apparatus, method and container
A device for producing fibrinogen includes a platen having a surface configured for heat exchange with a container, which is adhered to the platen by device of a vacuum and heat exchange allowing...
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6074605 |
Flow electroporation chamber and method
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cell, characterized by an optionally automated, continuous-flow,...
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6071910 |
Use of agents to treat eosinophil-associated pathologies
A therapeutic method comprising counteracting or preventing pathologies mediated by IL-5, including those characterized by eosinophil infiltration, degranulation and inflammation, by administering...
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6071422 |
Particle separation method and apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A...
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6071690 |
Ionomeric modified poly-ether-ester plastic container for cryogenic fluids
Plastic articles made of ionomeric modified poly-ether-ester are stored in a cryogenic fluid containing receptacle. The articles may be tubing or bags or articles of surgical equipment or clothing.
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6071689 |
System for improving yield of sexed embryos in mammals
Improved insemination systems particularly adapted to use for sex-selected sperm sorting include systems which achieve superovulation and then multiple embryo production with sexed embryos. These...
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6068970 |
Method of preserving cells using cell storage bag system
A cell storage bag system comprises a storage bag for containing cells to which at least one connecting tube having a closed end is connected, a reservoir container for containing an additive fluid...
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6068984 |
Antibodies to lymphocyte activation antigens and uses therefor
HB15-related lymphocyte activation antigens, and nucleic acid sequences encoding HB15-related antigens are disclosed. Also disclosed are antibodies reactive with HB15.
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6060322 |
Method for identification of reticulated cells
A reagent composition and method is provided for identification of reticulated cells from other cell types in a blood cell sample by using optical measurement. More particularly, the reagent...
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6060233 |
Methods for the lyophilization of platelets, platelet membranes or erythrocytes
The present invention provides methods for preserving living biological materials by lyophilization that enable cells and tissues to be stored for extended periods of time with minimal loss of...
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6060232 |
Organ storage solution
The invention relates to a solution for storing organs, preferably kidneys. To effectively prevent organ damage, the solution has a high sulfate content and a low chloride content. In particular,...
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6059968 |
Systems for processing and storing placenta/umbilical cord blood
Assemblies and methods process cord blood in a sterile fashion to avoid exposure to bacterial contamination. A transfer tube couples a cord blood processing container to an other container, which,...
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6056951 |
Method of reducing the chance of attack of cells in a body by the cellular immune system
A method of reducing the chance of disease resulting from mononuclear cells in a body attacking desirable cell antigens in the body, such as antigens expressed by normal body cells or desirable...
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6054121 |
Modulation of immune responses in blood-borne mesenchymal cells
The present invention relates to a population of blood borne mammalian cells that express a unique profile of surface markers that includes certain markers typical of connective tissue fibroblasts,...
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6054287 |
Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
A mathematical model, the membranes and devices based upon that model to optimize protocols for the addition or removal of cryoprotectant to or from biological cells, and a method to observe the...
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6051146 |
Methods for separation of particles
A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a fluid chamber for separating the particles form one another. Conduits are...
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6048464 |
Filter medium for leukocyte removal, method of making, and method of using thereof
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6045994 |
Selective restriction fragment amplification: fingerprinting
The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction...
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6046019 |
Diagnostic kits and methods for making granulocyte cell counts
Methods for detecting granulocytes and for providing an at least semiquantitative indication of granulocyte level and kits for implementing those methods. A blood sample is drawn, and components...
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6040132 |
Methods for the lyophilization of living biological materials
The present invention provides methods for preserving living biological materials by lyophilization that enable cells and tissues to be stored for extended periods of time with minimal loss of...
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6040177 |
High efficiency transduction of T lymphocytes using rapid expansion methods ("REM")
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing...
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6037116 |
Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials
The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of...
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6036857 |
Apparatus for continuous magnetic separation of components from a mixture
A magnetic system and apparatus having a multi-dimensional gradient for continuous, on-line separation of components from a mixture of chemical entities which comprises at least one separation...
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6030838 |
Hematological parameter
A new hematological parameter, namely mean hemoglobin density in one liter of blood (MDHL), is based on the new index of mean cell density of hemoglobin, MCHD, or more particularly, MDHL is...
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6030767 |
Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
This invention is directed to a method for inactivating pathogenic contaminants, such as viruses, bacteria, parasites and leukocytes, frequently found in whole blood or blood components, such as...
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6027688 |
Apparatus and method for inactivation of human immunodeficiency virus
An apparatus and method for the inactivation of infectious organisms such as viruses, bacteria, fungi and protozoa, and especially for the inactivation of human immunodeficiency virus in...
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6020120 |
Use of N-acetylcysteine to store red blood cells and a method of aging red cells with nitrogen
The invention provides a method of preserving red blood cells. The method comprises treating the red blood cells with about 2 mM to about 35 mM of N-acetylcysteine. The invention further provides a...
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6020205 |
Determination of intracellular antioxidant levels
A method of determining intracellular levels of water-soluble and fat-soluble antioxidants. Peripheral blood mononuclear cell lysates are prepared from an individual and analyzed by HPLC, either...
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6017691 |
4'-primary aminopsoralen and platelet compositions
Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding...
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6017527 |
Activated dendritic cells and methods for their activation
Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols....
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6015843 |
Process for making silanized colloidal silica
A method of preparing an aqueous suspension of organosilanized colloidal silica particles is disclosed. Such particles are used in a variety of applications including density gradient separation...
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