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6218182 |
Method for culturing three-dimensional tissue in diffusion gradient bioreactor and use thereof
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The...
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6218101 |
Enzymatic method for removal of cryoprotectants from cryopreserved animal cells
A method to remove cryoprotectants from cryopreserved biological cells and tissues is described. Enzymes are used to convert compounds used as cryoprotectants for cells during cryopreservation to...
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6218190 |
Method for testing a cell suspension
A method for testing a cell suspension comprises the steps of: (1) diluting a portion of the cell suspension such that the liquid of the diluted suspension has the same osmolality as the extra...
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6218100 |
5'-primary aminoalkyl psoralen compositions with platelets
Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding...
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6217863 |
Rationally designed polysaccharide lyases derived from heparinase I
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as as vectors and host cells are provided. Methods for using the modified...
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6214625 |
Composition and method for differentiation of basophils and eosinophils in blood
This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents...
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6214534 |
Biological compositions containing quenchers of type I and type II photodynamic reactions
The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or...
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6214535 |
Method for testing cardiac myocarditis or cardiomyopathy
The present invention relates to a method for the treatment of cardiac disease resulting from a viral infection of the cardiac tissue with human hepatitis C virus or EMC virus comprising...
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6210889 |
Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
An enriched fetal cell sample is prepared from maternal blood by first separating a maternal blood sample on a three layer density gradient, and collection of the layer containing the lymphocytes...
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6210574 |
System for separation of nucleated fetal erythrocytes from maternal blood samples
A system for separating nucleated cells from a blood sample includes a charge-flow separator (CFS), which separates blood into fractions according to the surface charge density characteristics...
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6210668 |
Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
The present invention discloses a procedure for the destruction of contaminating tumor cells in stem cell transplants ex vivo using intact bispecific antibodies.
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6210969 |
Composition and method for differentiation of basophil and eosinophil subpopulations of leukocytes in blood
This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents...
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6207066 |
Method for purification of a blood component
A method for rapid purification of a blood component from blood is described in which the blood plasma is first separated from the cellular blood elements by any conventional means, such as...
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6204056 |
Micropathological patient replica based on unadulterated whole blood
A patient replica is created from layered culture medium where solid culture medium is formed so that a discontinuity exists, for example, between layers of culture medium or between culture medium...
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6197540 |
Preparation and stabilization of cells using aged transition metal solutions
The invention is directed to novel stabilized blood compositions and methods of stabilizing blood compositions for use in the quality control of analytical techniques. The novel blood compositions...
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6197207 |
Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
Methods for reducing or preventing the transmission of transmissible spongiform encephalopathy through blood or blood products are provided. The methods require the intact removal of leukocytes...
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6197598 |
Devices and methods for separating cellular components of blood from liquid portion of blood
A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of...
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6197579 |
Cell washing device and method
Disclosed is a cell washing device and method of washing cells that utilizes the device. The device is particularly designed for sterile transfer of cells from a primary centrifuge tube and for...
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6194138 |
Method for flushing blood cells using gelatin
An aqueous solution of gelatin used as a flushing liquid for blood cells, in particular erythrocytes, in order to give no changes in the blood cells or at most slight, quality-impairing changes.
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6194207 |
Methods for the selective expansion of lymphocytes by in vitro cultivation
The invention is directed to methods for the production of selected populations of lymphocytes. Lymphocytes produced can be isolated and purified using well known and established procedures to...
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6194139 |
Methods for photodecontamination of pathogens in blood
Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding...
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6190870 |
Efficient enrichment and detection of disseminated tumor cells
Tumor cells, particularly carcinoma cells, are separated from peripheral blood by magnetic sorting. The tumor cells are magnetically labeled with antibodies directed to tissue specific antigens,...
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6187572 |
Method of inactivation of viral and bacterial blood contaminants
A method is provided for inactivating viral and/or bacterial contamination in blood cellular matter, such as erythrocytes and platelets, or protein fractions. The cells or protein fractions are...
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6183977 |
Determining hepatic status of a liver transplant recipient by measuring PI glutathione S-transferase
Hepatic status of a subject is determined by measuring the level of pi glutathione S-transferase (πGST) in a biological fluid such as bile or plasma from the subject by an immunoassay. An...
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6177019 |
Method and apparatus for removing tumor cells from tumor cell-contaminated stem cell products
A method for removing tumor cells from tumor cell-contaminated stem cell products is disclosed. One embodiment of the method relies on an in-line filtration device that includes a tumor cell...
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6177106 |
Method for fractionating red blood cells and antibacterial materials for bacterial proliferation inhibitors produced thereby
A method for fractionating red blood cells of human blood into three fractions comprises following steps; (a) human blood sample is mixed with dextran aqueous solution and maintained stationarily...
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6171777 |
Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for...
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6168718 |
Method for purifying blood plasma and apparatus suitable therefor
A method for purifying conventionally treated blood plasma to remove substantially all residual leukocytes while maintaining useful flow rates for medically useful amounts of plasma utilizes a...
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6168922 |
Methods and devices for collecting and storing clinical samples for genetic analysis
The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization,...
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6165785 |
Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications
A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a...
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6162396 |
Blood storage device and method for oxygen removal
The present invention relates to a storage device and method for the long-term storage of blood and, more particularly, to a blood storage device and method capable of removing oxygen from the...
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6159706 |
Application of enzyme prodrugs as anti-infective agents
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate...
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6156566 |
In vitro fertilization procedure dish
A culture dish for use in in vitro cell manipulation has an outer rim encompassing, and at right angles to, the periphery of the working surface. A parallel inner wall, spaced from the outer rim,...
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6156492 |
Adsorbent carrier containing immobilized sulfated polysaccharide and ligand for direct hemoperfusion
An adsorbent for use in direct hemoperfusion to adsorb and remove harmful substances from blood is prepared by immobilizing a sulfated polysaccharide and/or its salt on a water-insoluble carrier....
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6153113 |
Method for using ligands in particle separation
A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and...
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6153591 |
Dipeptide caspase inhibitors and the use thereof
The present invention is directed to novel dipeptides represented by the general Formula I: ##STR1## where R 1 -R 2 and AA are defined herein. The present invention relates to the discovery that...
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6146890 |
Method and system for cultivating macrophages
A method of cultivating macrophages from blood, including collecting a quantity of blood, fractionating the quantity of blood into a plasma fraction, a white blood cell fraction generally including...
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6143510 |
Measuring method using whole blood sample
A method for quantitatively measuring analyte in an undiluted whole blood sample is disclosed which involves contacting an undiluted whole blood sample comprising the analyte with...
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6140040 |
Method of mechanically separating microparticles suspended in fluids using particulate media
This invention relates to the selective separation of particles according to particle size. More particularly, this invention pertains to advanced particulate media which are carefully sized so as...
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6139757 |
Method of separating cells from blood using a filter having a changeable porosity
A method of separating cells from blood by using a filter apparatus having first and second ports and a filter member therebetween having a changeable porosity. The filter member includes a stack...
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6139836 |
Method of encapsulating biologically active agents within erythrocytes, and apparatus therefor
A method and apparatus for the encapsulation of biologically active agents in red blood cells (RBCS) is disclosed. The method is characterized in that lysed and partially lysed RBCs are...
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6139878 |
Method for preparing a diafiltered stabilized blood product
A method using diafiltration to prepare a blood product is described. The method removes contaminating plasma proteins from whole blood or blood products. Diafiltration may be used on...
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6136960 |
Method for evaluation of the ratio of amounts of biomolecules or their sub-populations in a mixture
The present invention is directed to a method of determining the ratio of the concentration or amounts of two or more chemical compounds and/or biopolymers, or of the relative amounts of...
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6136586 |
Methods for the selective modification of viral nucleic acids
This invention provides means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions without significant alteration of proteins or other...
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6132952 |
Storage system comprising an emptied zona pellucida and spermatozoa placed therein and a method of cryopreservation
A procedure for cryopreservation and efficient post-thaw recovery of a single or few cells, preferably human spermatozoa, their precursor cells or blastomeres, which is achieved by injecting cells...
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6132981 |
Method for detecting a mammal's prior exposure to radiation or radiomimetic agents
The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin...
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6129912 |
Polyethylene glycol-protein compositions which reduce the antigenic display of red blood cells
The present invention provides a composition of matter, comprising a red blood cell coated a polymeric mixture of polyethylene glycol and albumin. Also provided is a method of blocking blood group...
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6130034 |
Use of CYB medium for the transportation and storage of sperm
The use of CYB medium for the storage and/or transportation of semen at ambient temperature.
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6129848 |
Method for continuous magnetic separation of components from a mixture
A magnetic system and apparatus having a multi-dimensional gradient for continuous, on-line separation of components from a mixture of chemical entities which comprises at least one separation...
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6130086 |
Composition for an in vitro fertilization medium
The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the...
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