|
Match
|
Document |
Document Title |
|
|
8183012 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
|
|
|
8182991 |
FEN-1 endonucleases, mixtures and cleavage methods
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
|
|
|
8137938 |
Method for producing an L-amino acid
An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is...
|
|
|
8119382 |
Variant of KpnI restriction endonuclease
Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of...
|
|
|
8093061 |
Methods of determining potency of chemically-synthesized oligonucleotides
Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or...
|
|
|
8048664 |
Polynucleotides encoding modified DNA cleavage enzymes and host cells therefor
Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic...
|
|
|
8039240 |
Recombinant human T2 RNase and uses thereof
The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or...
|
|
|
8039687 |
Method for screening genomic DNA fragments
The present invention provides a method for selecting genomic DNA fragments which are useful for providing a plant with an agriculturally advantageous improvement. The method of the present...
|
|
|
8034598 |
Engineered cleavage half-domains
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
|
|
|
8034597 |
Microorganism-derived psychrophilic endonuclease
A polypeptide having an endonuclease activity derived from a psychrophilic microorganism Shewanella sp. strain Ac10, which exhibits high activity at low temperatures, can remove any nucleic acid...
|
|
|
8034998 |
Reproductive ablation constructs
The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species....
|
|
|
8029782 |
Therapeutic ribonucleases
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
|
|
|
8017356 |
Endoribonuclease
A polypeptide having a endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a...
|
|
|
8008055 |
Thermotolerant ribonuclease H
Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
|
|
|
7960159 |
Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions
The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide...
|
|
|
7951927 |
Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates
The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further...
|
|
|
7935509 |
Intracellular production of a nuclease
Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and...
|
|
|
7897372 |
I-CreI meganuclease variants with modified specificity, method of preparation and uses thereof
Method of preparing 1-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic...
|
|
|
7858096 |
Mutant forms of meningococcal ADP-ribosylating toxin
NMB1343 is an ADP-ribosylating toxin from Neisseria meningitidis. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s)...
|
|
|
7851679 |
Reproductive ablation constructs
The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species....
|
|
|
7842489 |
Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y (SEQ ID NO: 23 is residues 1-153 of pdb Ig9y) and a second...
|
|
|
7807431 |
Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions
The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide...
|
|
|
7785852 |
Cleavage of nucleic acids
The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and ide...
|
|
|
7776535 |
Site-specific incorporation of fluorinated amino acids into proteins
This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their...
|
|
|
7741086 |
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
LSD1, a homolog of nuclear amine oxidases, functions as a histone demethylase and transcriptional co-repressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active...
|
|
|
7741541 |
Method for obtaining improved fertility restorer lines for transgenic male sterile crop plants and a DNA construct for use in said method
A method for obtaining improved fertility restorer lines for male sterile crop plants and a DNA construct for use in said method are disclosed. The invention relates to the simultaneous use of two...
|
|
|
7666640 |
DNA sequences for the expression of alloproteins
The present invention discloses an expression method for non-naturally-occurring amino acid-containing protein comprising: expressing in animal cells: (A) a mutant tyrosyl-tRNA synthetase that is a...
|
|
|
7625717 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
|
|
|
7566555 |
Method of expressing proteins comprising non-naturally-occurring amino acids
A method of expressing a protein having an unnatural amino acid integrated thereinto comprising expressing (A) a mutant tyrosyl tRNA synthase that is derived from Escherichia coli-origin tyrosyl...
|
|
|
7560248 |
Oxidation-resistant ribonuclease inhibitor
Mutant forms of ribonuclease inhibitor are described which are rendered more resistant to oxidation while retaining affinity for both ribonuclease and angiogenin. The mutant forms have another...
|
|
|
7544487 |
Fusion proteins containing recombinant cytotoxic RNAses
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse...
|
|
|
7527943 |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of...
|
|
|
7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
|
|
|
7527956 |
Modified human acid sphingomyelinase having increased activity, and methods for making the same
Deficiencies in the enzymatic activity of acid sphingomyelinase (ASM) result in Niemann-Pick disease. A variety of modifications which eliminate the activity of the free thiol on the C-terminal...
|
|
|
7525015 |
Prevention of transgene escape in genetically modified perennials
Genes can be introduced into plants that confer desirable traits such as, drought and stress tolerance, insect and pest resistance, as well as environmental qualities such as phyto-remediation....
|
|
|
7495148 |
Double recoverable block of function
An improved double Recoverable Block of Function (RBF) system for transgene containment with enhanced reliability is disclosed. The system includes two blocking constructs (BCs) at the opposite...
|
|
|
7491524 |
Human RNase III and compositions and uses thereof
The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
|
|
|
7476391 |
Anti-bacterial vaccine compositions
Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of...
|
|
|
7476500 |
In vivo selection system for enzyme activity
The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell...
|
|
|
7473542 |
Cysteinized ribonuclease and targeting moiety conjugated thereto
A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue.
|
|
|
7459298 |
Purification, cloning and biochemical characterization of XendoU, endoribonucleasic activity involved in small nuclear RNA splicing-independent biosynthesis in Xenopus laevis
Cloning and characterization of the gene for Mn++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends.
|
|
|
7453025 |
Reproductive ablation constructs
The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species....
|
|
|
7442535 |
Fusion protein incorporating a cysteinized ribonuclease
A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.
|
|
|
7439035 |
Method of identifying or characterizing a compound that modulates ribonuclease H activity
The invention relates to a substrate and method for the assay of ribonuclease H activity. The substrate comprises a DNA/RNA heteroduplex molecule having fluorophore and quencher molecules in close...
|
|
|
7432365 |
DNA molecules encoding beta clamp proteins of gram positive bacteria
The present invention relates to beta protein-encoding genes from Gram positive bacterium. Expression systems and host cells containing these genes are also disclosed.
|
|
|
7432308 |
Therapeutic compositions for the treatment of a respiratory tract disease
The equilibrium between G actin and F actin is shifted towards the F actin confirmation with compounds such as the ionic form of magnesium or potassium. The higher amount of F actin decreases the...
|
|
|
7429468 |
Mutant B-type DNA polymerases exhibiting improved performance in PCR
The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3′-5′-exonuclease domain and the C-terminal pol...
|
|
|
7422889 |
Dre recombinase and recombinase systems employing Dre recombinase
The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The...
|
|
|
7422888 |
Thermotolerant ribonuclease H
Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
|
|
|
7410647 |
Antigenic polypeptides
A method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to...
|