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7410647 |
Antigenic polypeptides
A method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to...
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7399476 |
Nucleic acid free ghost preparations
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.
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7378262 |
Reversibly modified thermostable enzymes for DNA synthesis and amplification in vitro
The invention relates to a composition comprising a first modified thermostable enzyme exhibiting 3′exonuclease activity but essentially no DNA polymerase activity and a second modified...
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7247464 |
CspCI restriction endonuclease
A novel restriction endonuclease has been identified from Citrobacter species 2144 (NEB#1398) which can cleave at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:13) in double-stranded DNA molecules.
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7238853 |
Molecular mechanisms for gene containment in plants
The present invention provides a molecular mechanism for gene containment in sexually reproducing transgenic plants. The mechanism is achieved with a molecular construct comprising a blocking...
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7232678 |
Identification of oligoadenylate synthetase-like genes
The present invention relates to compositions and methods for modulating conception in animals. More particularly, the composition modulates mRNA degradation during gametogenesis and early...
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7189546 |
Polypeptide, cDNA encoding the same, and use of them
A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the...
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7189393 |
Recombinant anti-tumor RNAse
This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with...
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7186538 |
Type II restriction endonuclease, CstMI, obtainable from Corynebacterium striatum M82B and a process for producing the same
In accordance with the present invention, there is provided a novel type II restriction endonuclease, obtainable from Corynebacterium striatum M82B, hereinafter referred to as “CstMI”, which...
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7186520 |
Substrate for assaying ribonuclease H activity
The invention relates to a substrate and method for the assay of ribonuclease H activity. The substrate comprises a DNA/RNA heteroduplex molecule having fluorophore and quencher molecules in close...
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7150982 |
RNA detection assays
The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection...
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7135324 |
Viral recombinases, related articles, and methods of use thereof
A Herpes simplex virus (HSV) recombinase comprises a purified or isolated alkaline nuclease and a single stranded DNA binding protein. In HSV-1, the alkaline nuclease is the UL12 protein and the...
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7129075 |
Isolated CEL II endonuclease
The present invention relates to the isolation and characterization of CEL I and CEL II endonuclease proteins. Methods and kits for identifying mismatches in double-stranded DNA are also provided.
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7122364 |
FEN endonucleases
The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection...
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7118901 |
Recombinant bovine pancreatic desoxyribonuclease I with high specific activity
A method is provided for the production of a bovine pancreatic protein with a specific desoxyribonuclease activity of at least 6,000 units per mg of protein. Methylotrophic yeast is used as a...
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7115407 |
Recombinant type II restriction endonucleases, MmeI and related endonucleases and methods for producing the same
In accordance with the present invention, there is provided a DNA (deoxyribonucleic acid) fragment which encodes the MmeI type II restriction endonuclease enzyme. This one polypeptide possesses two...
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7101697 |
Restriction endonucleases, method of synthesis and use thereof
A restriction endonuclease having one DNA binding site is proposed, synthesized from a restriction endonuclease that has one C-terminal domain and one N-terminal domain and two DNA binding sites,...
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7098016 |
Ribonuclease zymogen design
An enzyme is re-engineered to be a zymogen, an enzyme precursor which is converted into an enzyme by protease cleavage. In the example described here, an RNase A enzyme is converted into a zymogen...
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7094560 |
Stabilization of T4 endonuclease V
The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods...
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7091026 |
Artificial endonuclease
The present invention provides artificial endonucleases and methods to prepare and use those endonucleases.
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7081358 |
Method for engineering strand-specific, sequence-specific, DNA-nicking enzymes
Methods are provided for converting into a sequence specific strand specific and location specific DNA nicking endonuclease, a restriction endonuclease that recognizes an asymmetric DNA sequence,...
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7078211 |
Nucleic acid molecules encoding endonucleases and methods of use thereof
We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with...
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7067298 |
Compositions and methods of using a synthetic Dnase I
Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA...
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7067135 |
Methods and compositions for the treatment and prevention of Staphylococcus aureus infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
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7052897 |
Alteration of restriction endonuclease specificity by genetic selection
Methods and compositions are provided for altering the DNA recognition and cleavage characteristics of an endonuclease without prior knowledge of the endonuclease's three-dimensional structure...
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7049123 |
Deoxyribonuclease, gene encoding same and use thereof
This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic...
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7029900 |
Type II restriction endonuclease BtgZI, obtainable from Bacillus thermoglucosidasius 36A and a process for producing the same
In accordance with the present invention, there is provided a novel restriction endonuclease obtainable from Bacillus thermoglucosidasius 36A (NEB#1384), hereinafter referred to as “BtgZI”,...
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7029899 |
Selective toxicity of amino-terminal modified rnase a superfamily polypeptides
This invention provides RNase A superfamily polypeptides with modified amino terminal which can be used to selectively kill target Kaposi's sarcoma cells, neoplastic endothelial cells, and...
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7018825 |
DNase liquid solutions
The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions...
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7011966 |
Method for cloning and expression of AcuI restriction endonuclease and AcuI methylase in E. coli
The present invention relates to recombinant DNA encoding the AcuI restriction endonuclease as well as AcuI methylase, and expression of AcuI restriction endonuclease and AcuI methylase in E. coli...
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6987214 |
Methods of suppressing flowering in transgenic plants
The present invention provides a transgenic plant characterized by suppressed flowering. The transgenic plant contains a nucleic acid molecule including a floral organ selective regulatory element...
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6982158 |
Extraction and purification of phosphodiesterase 1
A process for purifying a phosphodiesterase 1 (PDE-1) from a cell including heating an extract of a cell formed from a solution including at least one divalent cation, to increase the specific...
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6958230 |
Method for cloning and expression of SbfI restriction endonuclease and SbfI methylase in E. coli
The present invention relates to: recombinant DNA encoding the SbfI restriction endonuclease as well as the SbfI methylase, and expression of the SbfI restriction endonuclease and SbfI methylase in...
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6936432 |
Bacterial RNase P proteins and their use in identifying antibacterial compounds
The invention features novel RNase P molecules and nucleic acids encoding the same. Methods for discovery of antimicrobial compounds are also featured.
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6932965 |
Purified forms of DNase
The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human...
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6925394 |
Crystal structure of the 30s ribosome
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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6919194 |
Method for cloning and expression of Tth111II restriction endonuclease-methylase in E. coli
The present invention relates to recombinant DNA which encodes the Tth111II restriction endonuclease-methylase fusion protein (Tth111IIRM), expression of Tth111II restriction endonuclease-methylase...
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6905837 |
Method for screening restriction endonucleases
A method is provided for identifying a restriction endonuclease, which includes the steps of (a) screening a target DNA sequence for the presence of known methylase sequence motifs, (b) identifying...
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6893854 |
Nuclease
A process for producing a polynucleotide encoding a restriction endonuclease with an altered specificity, which process comprises:
(a) mutagenising a polynucleotide encoding a restriction...
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6881561 |
Endonuclease of immune cell, process for producing the same and immune adjuvant using the same
The present invention relates to a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded...
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6881559 |
Mutant B-type DNA polymerases exhibiting improved performance in PCR
The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3′-5′-exonuclease domain and the C-terminal...
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6869786 |
Method for cloning and expression of BsrGI restriction endonuclease and BsrGI methyltransferase in E. coli
The present invention relates to recombinant DNA encoding the BsrGI restriction endonuclease as well as BsrGI methyltransferase, expression of BsrGI restriction endonuclease and BsrGI...
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6869604 |
Recombinant anti-tumor RNAse
This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with...
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6858776 |
Plants having modified reproductive capacity
This invention relates to plants having modified reproductive capacity. In particular, it relates to a plant reproductive tissue specific promoter, the PrAG1 promoter isolated from Pinus radiata ,...
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6855530 |
Human RNase H1 mutants
A human RNase H polypeptide and methods of use are provided.
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6849776 |
Molecular control of transgene segregation and its escape by a recoverable block of function (RBF) system
The invention is related to a method and a DNA construct for controlling transgene segregation in a sexually reproducing multicellular organism (SRMO), especially in such SRMOs which are...
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6846656 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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6794172 |
Method for cloning and expression of PpuMI restriction endonuclease and PpuMI methylase in E. coli
The present invention relates to recombinant DNA encoding the PpuMI restriction endonuclease as well as PpuMI methylase, expression of PpuMI restriction endonuclease and PpuMI methylase in E. coli...
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6791011 |
Protein complementation in transgenic plants
The invention relates to pairs of parent plants for producing hybrid seeds and to methods for producing plants with a desired phenotype. The desired phenotype is an active enzyme, a regulatory...
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6780632 |
Purification of cellular components that are substantially RNA free
The invention relates to host cells and methods of preparing a substantially RNA-free cellular component, comprising culturing cells producing the cellular component in a medium and lysing the...
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