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7018825 |
DNase liquid solutions
The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions...
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7011966 |
Method for cloning and expression of AcuI restriction endonuclease and AcuI methylase in E. coli
The present invention relates to recombinant DNA encoding the AcuI restriction endonuclease as well as AcuI methylase, and expression of AcuI restriction endonuclease and AcuI methylase in E. coli...
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6982158 |
Extraction and purification of phosphodiesterase 1
A process for purifying a phosphodiesterase 1 (PDE-1) from a cell including heating an extract of a cell formed from a solution including at least one divalent cation, to increase the specific...
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6958230 |
Method for cloning and expression of SbfI restriction endonuclease and SbfI methylase in E. coli
The present invention relates to: recombinant DNA encoding the SbfI restriction endonuclease as well as the SbfI methylase, and expression of the SbfI restriction endonuclease and SbfI methylase in...
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6936432 |
Bacterial RNase P proteins and their use in identifying antibacterial compounds
The invention features novel RNase P molecules and nucleic acids encoding the same. Methods for discovery of antimicrobial compounds are also featured.
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6932965 |
Purified forms of DNase
The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human...
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6925394 |
Crystal structure of the 30s ribosome
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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6919194 |
Method for cloning and expression of Tth111II restriction endonuclease-methylase in E. coli
The present invention relates to recombinant DNA which encodes the Tth111II restriction endonuclease-methylase fusion protein (Tth111IIRM), expression of Tth111II restriction endonuclease-methylase...
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6905837 |
Method for screening restriction endonucleases
A method is provided for identifying a restriction endonuclease, which includes the steps of (a) screening a target DNA sequence for the presence of known methylase sequence motifs, (b) identifying...
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6893854 |
Nuclease
A process for producing a polynucleotide encoding a restriction endonuclease with an altered specificity, which process comprises:
(a) mutagenising a polynucleotide encoding a restriction...
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6881561 |
Endonuclease of immune cell, process for producing the same and immune adjuvant using the same
The present invention relates to a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded...
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6869786 |
Method for cloning and expression of BsrGI restriction endonuclease and BsrGI methyltransferase in E. coli
The present invention relates to recombinant DNA encoding the BsrGI restriction endonuclease as well as BsrGI methyltransferase, expression of BsrGI restriction endonuclease and BsrGI...
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6858776 |
Plants having modified reproductive capacity
This invention relates to plants having modified reproductive capacity. In particular, it relates to a plant reproductive tissue specific promoter, the PrAG1 promoter isolated from Pinus radiata ,...
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6855530 |
Human RNase H1 mutants
A human RNase H polypeptide and methods of use are provided.
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6849776 |
Molecular control of transgene segregation and its escape by a recoverable block of function (RBF) system
The invention is related to a method and a DNA construct for controlling transgene segregation in a sexually reproducing multicellular organism (SRMO), especially in such SRMOs which are...
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6846656 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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6794172 |
Method for cloning and expression of PpuMI restriction endonuclease and PpuMI methylase in E. coli
The present invention relates to recombinant DNA encoding the PpuMI restriction endonuclease as well as PpuMI methylase, expression of PpuMI restriction endonuclease and PpuMI methylase in E. coli...
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6791011 |
Protein complementation in transgenic plants
The invention relates to pairs of parent plants for producing hybrid seeds and to methods for producing plants with a desired phenotype. The desired phenotype is an active enzyme, a regulatory...
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6780632 |
Purification of cellular components that are substantially RNA free
The invention relates to host cells and methods of preparing a substantially RNA-free cellular component, comprising culturing cells producing the cellular component in a medium and lysing the...
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6777210 |
Method and reagents for inactivating ribonucleases RNase A, RNase I and RNase T1
The present invention is a general method for irreversibly inactivating ribonucleases. Ribonucleases are completely inactivated by treating them with a reducing agent and heat. RNA samples...
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6777187 |
Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates
Improved methods and reagents for chromosome walking of nucleic acid are discussed herein. A library of amplifiable nick translation molecules is generated, and a chromosome walk is initiated from...
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6764843 |
Method of cloning and expression of BsmBI restriction endonuclease and BsmBI methylase in E. coli and purification of BsmBI endonuclease
The present invention relates to recombinant DNA that encodes the BsmBI restriction endonuclease as well as BsmBI methyltransferase, expression of BsmBI restriction endonuclease and BsmBI methylase...
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6759575 |
Barstar gene
An improved barstar gene and improved barstar protein can be used to neutralize the activity of a barnase in eukaryotic cells, particular in plant cells. The improved barstar gene can be used to...
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6759226 |
Enzymes for the detection of specific nucleic acid sequences
The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that...
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6743968 |
Methods and compositions to reduce or eliminate transmission of a transgene
Genetic constructs and methods are disclosed for the production, maintenance and control of transgenes in transgenic eukaryotic organisms that undergo meiosis in which pollen or sperm can be...
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6730479 |
Detection of nucleic acid hybrids
Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those...
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6673588 |
Method for cloning and expression of MspA1l restriction endonuclease and MspA1l methylase in E. coli
The present invention relates to recombinant DNA coding for the MspA1I restriction endonuclease as well as MspA1I methylase, expression of MspA1I restriction endonuclease and MspA1I methylase in ...
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6649393 |
Mutant form of cytotoxic ribonucleolytic protein which allows production by recombinant methods
The present invention provides recombinant Onc (rOnc) compositions and methods. Recombinant Onc proteins of the invention have an amino terminal methionine and comprise an Onc polypeptide. The...
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6635463 |
Enzymes for the detection of nucleic acid sequences
The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that...
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6632665 |
Human gene encoding 3′-5′ exonuclease
An isolated nucleic acid molecule encodes the genomic sequence encoding a human 3′-5′ exonuclease. A human exonuclease independent of DNA polymerase is produced in host cells from recombinant...
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6632639 |
Mutant E. coli strains, and their use for producing recombinant polypeptides
The invention concerns the use of Escherichia coli ( E. coli ) strains whereof the gene coding for the Rnase E comprises a mutation such that the enzyme produced when said mutated gene is...
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6627799 |
Plants with modified stamen cells
A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the...
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6610475 |
Kits for processing biological specimens for nucleic acid hybridization assays, target amplification reactions and similar uses
The present invention features kits for making available a desired nucleic acid contained in a biological sample. The kits contain an acid for acidifying the biological sample to a pH at which...
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6596524 |
Method for cloning and expression of BsmAi restriction endonuclease and BsmAI methylase in E. coli
The present invention relates to recombinant DNA which encodes the BsmAI restriction endonuclease as well as BsmAI methylase, expression of BsmAI restriction endonuclease and BsmAI methylase in E....
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6593122 |
Method for cloning and expression of BseRI restriction endonuclease and BseRI methylase in E. coli
The present invention relates to recombinant DNA that encodes the BseRI restriction endonuclease as well as M.BseRI, expression of BseRI restriction endonuclease and M.BseRI in E. coli cells...
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6589769 |
Method for cloning and expression of TspRI restriction endonuclease and TspRI methylase in E. coli
The present invention relates to recombinant DNA that encodes the TspRI restriction endonuclease as well as TspRI methylase, expression of TspRI restriction endonuclease and TspRI methylase in E....
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6586220 |
Method for cloning and expression of BsaWI restriction endonuclease and BsaWI methylase in E. coli
The present invention relates to recombinant DNA encoding the BsaWI restriction endonuclease as well as BsaWI methylase, expression of BsaWI restriction endonuclease and BsaWI methylase in E. coli...
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6569429 |
Human DNase II
This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of...
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6569660 |
Human DNase
A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
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6563026 |
Hybrid winter oilseed rape and methods for producing same
This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, wherein harboring a specific transformation event. It pertains to winter oilseed rape plants, more...
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6562611 |
FEN-1 endonucleases, mixtures and cleavage methods
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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6528296 |
Endonuclease
The present invention relates to a site-specific endonuclease which recognizes a specific nucleotide sequence, to a gene coding for the endonuclease, to a recombinant vector containing the gene, to...
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6524578 |
Use of nuclease to reduce wrinkles and discolorations in humans
A method for reducing wrinkles and discoloration on human tissue skin cells which involves forming a nuclease solution and applying the nuclease solution to portions of a subject's body where the...
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6521458 |
Compositions and methods for improved plant transformation
The present invention provides methods for eliminating plants containing non-T-DNA sequences derived from a T-DNA vector. More specifically, the present invention provides a method for killing...
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6482626 |
Human DNase
This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic...
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6451307 |
3′-exonuclease, production and use thereof
The present invention relates to a poly(A)-specific 3′-exonuclease activity which can be obtained by chromatographically purifying a crude extract of animal or human cells and to its use for...
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6444208 |
Ribonuclease III from Streptococcus pneumoniae
The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc...
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6423492 |
Hybridization assay for detecting a single-stranded target nucleic acid in which excess probe is destroyed
A method is disclosed for detecting single-stranded target nucleic acid ( 2 ) which comprises the steps of forming a hybrid between said target nucleic acid and a nucleic acid probe ( 4 ), said...
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6417208 |
Method of identification of inhibitors of PDE1C
The present invention provides a method of identifying novel agents that increase glucose dependent insulin secretion in pancreatic islet cells as well as methods of treating diabetes using the...
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6413758 |
Method for cloning and expression of Bpml restriction endonuclease in E. coli
The present invention relates to recombinant DNA which encodes the BpmI restriction endonuclease as well as BpmI methyltransferase, expression of BpmI restriction endonuclease from E. coli cells...
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