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7625736 |
Methods for preparing immunogenic conjugates
Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a...
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7595181 |
Thermostable esterases from thermophilic bacteria
The present invention relates to a newly identified hydrolase from thermophilic microorganisms having thermostable properties, and more specifically, to a novel thermostable hydrolase showing high...
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7556954 |
MOS transistor and manufacturing method thereof
Disclosed are a MOS transistor having a low resistance ohmic contact characteristic and a manufacturing method thereof capable of improving a drive current of the MOS transistor. A gate oxide...
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7531331 |
Butynol I esterase
The invention relates to novel proteins from Pseudomonas glumae , having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefor, to expression...
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7524494 |
Degradation of hydrophobic ester pesticides and toxins
The present invention relates to methods and enzymes for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants...
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7510859 |
Subtilisin variants with improved perhydrolase activity
The invention relates to novel perhydrolases, derived from the protease Carlsberg by amino acid exchange in positions 11, 15, 21, 38, 50, 54, 58, 77, 83, 89, 93, 96, 107, 117, 120, 134, 135, 136,...
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7485294 |
Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
Forms of colonic delivery suited to be used orally and designed for colonic delivery of active ingredients selected from the group comprising enzymes capable of inactivating macrolide antibiotics...
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7438904 |
High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same
A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting...
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7422887 |
Phospholipase A2 and gene thereof
To provide a novel phospholipase A 2 (PLA 2 ) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA 2 or a...
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7416867 |
Enzymatic production of (meth)acrylic acid esters
A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof.
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7405070 |
Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme
Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior...
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7381556 |
Nucleic acids encoding deallergenized proteins and permuteins
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were...
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7335502 |
Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene
The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a...
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7329519 |
Glucose dehydrogenase β subunit and DNA encoding the same
A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequnece of a N-terminal signal sequence region of a GDH β subunit derived from ...
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7312062 |
Lipolytic enzyme variants
The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a...
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7288400 |
Nucleic acids encoding esterases and methods of making and using them
The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased...
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7285405 |
Biosynthetic gene cluster for jerangolids
Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described,...
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7271198 |
Method of treating autoimmune diseases
A method of treating an autoimmune disease comprising administering to the subject a treatment effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof.
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7270984 |
Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum
Isolated nucleic acid molecules, designated sugar metabolism and oxidative phosphorylation (SMP) nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum , are...
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7238511 |
Preparation of deallergenized proteins and permuteins
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were...
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7238503 |
Process for making fluoroleucine ethyl esters
The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other...
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7229817 |
Recombinant porcine liver esterases, their use and a method for the production thereof
The invention relates to biotechnologically expressible, enzymically active recombinant porcine liver esterases, to a biotechnological method for the preparation thereof and to the use thereof in...
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7226771 |
Phospholipases, nucleic acids encoding them and methods for making and using them
The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity, nucleic acids...
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7223582 |
Esterase, its DNA, its overexpression and production of optically active aryl propionic acids using the same
The present invention relates to an esterase, its DNA, its overexpression and a method for preparing an optically active aryl propionic acid of formula (1) using the same in high yield,
wherein...
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7211387 |
DNA molecule encoding a variant paraoxonase and uses thereof
This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as a method and a kit for...
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7176011 |
Lipid cleavage enzyme
A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates...
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7176010 |
Isolated human protein having esterase activity and DNA encoding the same
The present invention provides novel esterase proteins, Specifically, the present invention provides proteins having the same or substantially the same amino acid sequence as the amino acid...
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7112428 |
Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene
The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a...
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7091025 |
Malathion carboxylesterase
The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester...
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7070973 |
Butyrylcholinesterase variants and methods of use
The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries...
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7063977 |
Enzymatic resolution of t-butyl taxane derivatives
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula
wherein R 1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting...
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7060474 |
Carbohydrate oxidase and use thereof in baking
The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding...
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7060264 |
Insect inhibitory lipid acyl hydrolases
The present invention discloses DNA sequences encoding plant and novel lipid acyl hydrolase proteins having coleopteran specific insect inhibitory activity, as well as variants and permuteins...
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7052896 |
Lactobacillus rhamnosus polynucleotides, polypeptides and methods for using them
Novel polynucleotides isolated from Lactobacillus rhamnosus , as well as probes and primers, genetic constructs comprising the polynucleotides, biological materials, including plants,...
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7049122 |
Mutant-type lipases and applications thereof
The present invention provides mutant-type lipases which demonstrate superior lipolytic and esterific activities. The mutant-type lipases are characterized by an amino acid alteration at the...
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7049121 |
Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides...
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7005287 |
Process for the enzymatic modification of pectin
A process for modifying a pectin comprising providing a host having PME activity and PG activity; transforming said host by silencing PG activity thereby to provide an increased PME to PG ratio;...
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6989261 |
Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of...
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6987010 |
Process for the enzymatic preparation of enantiomer-enriched β-amino acids
The present invention relates to processes for the preparation of enantiomerically enriched β-amino acids. The invention also relates to advantageous esters of β-amino acids of the general...
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6960460 |
Esterase gene and its use
An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:
wherein R 1 is hydrogen or...
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6960459 |
Cutinase variants
Variants of fungal cutinases having improved thermostability comprise substitution of one or more specified amino acid residues and/or a specified N-terminal extension. The variants may optionally...
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6953678 |
Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes
A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a...
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6929938 |
25501, a human transferase family member and uses therefor
The invention provides isolated nucleic acids molecules, designated 25501 nucleic acid molecules, which encode novel transferase family members. The invention also provides antisense nucleic acid...
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6900039 |
Carbohydrate oxidase and use thereof in baking
The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding...
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6875677 |
Method to control the interfacial layer for deposition of high dielectric constant films
Methods of forming an interfacial layer on a hydrogen-passivated substrate are provided. These methods utilize atomic layer deposition techniques incorporating metal nitrate-based precursors, such...
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6849257 |
Lipid hydrolysis therapy for atherosclerosis and related diseases
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances...
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6846656 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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6844178 |
Recombinant kid pregastric esterase and methods for its production and use
The present invention provides kPGE and derivative polypeptides which are capable of being produced by genetic recombination and used to produce EMCs. This invention further provides nucleic acid...
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6828136 |
Esterase enzymes, DNA encoding esterase enzymes and vectors and host cells incorporating same
A novel DNA is provided which encodes an enzyme having esterolytic activity isolated from Aspergillus . Also provided for is a method of isolating DNA encoding an enzyme having esterolytic...
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6828129 |
Esterase genes and uses of the same
The present invention provides a novel gene encoding a protein having an excellent catalyst ability for producing (S)-N-substituted cyclic imino acid represented by the general formula (2) (=the...
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