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7612032 |
Method for treating oncological diseases
A method to treat solid tumors and other oncological diseases consists of parenterally injecting an agent which destroy's blood's extracellular DNA into the systemic blood circulation of a cancer...
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7598067 |
PDEs and uses thereof
The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention...
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7598066 |
Gene encoding vitamin b6 phosphate phosphatase and use thereof
Disclosed is an isolated DNA encoding vitamin B 6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a...
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7592140 |
2′, 5′-oligoadenylate phosphodiesterase
Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the...
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7588925 |
Phospholipases and uses thereof
The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel phospholipase isolated from Aspergillus niger . The invention features the full length...
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7585655 |
Nucleic acid encoding a fusion protein incorporating a cysteinized ribonuclease
A nucleic acid encodes a novel fusion protein. The fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.
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7585654 |
Nucleic acid encoding cysteinized ribonuclease to which a targeting moiety can be conjugated
A nucleic acid encodes a cysteinized RNase to which a targeting moiety can be conjugated.
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7575901 |
Method for producing nucleotide by fermentation
Nucleoside 5′-phosphate ester is produced by culturing a bacterium belonging to the genus Escherichia having an ability to produce nucleoside 5′-phosphate ester, in which ushA gene and aphA...
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7572617 |
Thermostable ribonuclease H obtained from Archeoglobus profundus
An isolated polypeptide having a thermostable ribonuclease H activity from Archaeoglobus profundus is highly useful in genetic engineering, as well as a gene encoding this polypeptide and a...
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7566556 |
Enhancing enzyme thermostability by mixing with sorghum liquor waste
A composition containing a thermolabile protein admixed with a liquor waste. Also disclosed is a method of preparing such a composition which contains a protein with enhanced thermostability.
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7560261 |
Nucleic acid sequences encoding CEL II endonuclease
The present invention relates to isolated nucleic acid sequences encoding CEL II endonuclease and vectors and host cells for producing a protein encoded thereby.
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7556953 |
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an N-terminal leader sequence
A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a leader sequence.
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7556950 |
Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)
Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and...
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7553635 |
Process for production of cephalosporin C
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum , to vectors which comprise such a nucleic acid molecule, to Acremonium...
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7550262 |
PTPN11 (SHP-2) mutations and cancer
Diagnostic and therapeutic applications for certain types of cancer and precancerous conditions, including those deriving from hematologic cells, are described. Of particular interest are those...
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7510854 |
Corynebacterium glutamicum genes encoding metabolic pathway proteins
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7504247 |
2-O sulfatase compositions and methods of degradation therewith
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7494645 |
Lipid phosphate phosphatases and uses thereof for treating neuronal diseases
Lipid phosphate phosphatase proteins, genes coding for them, vectors and cells comprising them, antibodies directed against them, methods of identifying compounds binding to them and functional...
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7473542 |
Cysteinized ribonuclease and targeting moiety conjugated thereto
A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue.
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7468429 |
Recombinant Candida rugosa lipases
The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the ...
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7465570 |
Variant lipolytic enzymes
The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough...
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7462482 |
Human smooth muscle myosin heavy chain
The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
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7459298 |
Purification, cloning and biochemical characterization of XendoU, endoribonucleasic activity involved in small nuclear RNA splicing-independent biosynthesis in Xenopus laevis
Cloning and characterization of the gene for Mn ++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends.
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7452706 |
Recombinant bacterial phytases and uses thereof
A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native...
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7449317 |
Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells incorporating same
DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella . Also provided for is a method of isolating DNA encoding an enzyme...
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7445891 |
Nucleic acid triggered catalytic drug and probe release
The present invention provides methods and combinations of compositions for the modulation of diseases caused by a subject possessing a disease-specific nucleic acid sequence. Included are methods...
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7442535 |
Fusion protein incorporating a cysteinized ribonuclease
A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.
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7442398 |
Phytase produced from Citrobacter braakii
The present invention relates to phytase enzyme, a gene encoding the enzyme, and a Citrobacter sp. producing the enzyme. Particularly, the present invention relates to the phytase enzyme produced...
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7438904 |
High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same
A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting...
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7432348 |
180 kD protein that interacts with protein histidine phosphatase 1
180 KDa protein histidine phosphatase interacting protein (PHPIP-180) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also...
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7432098 |
Phytases and methods for making and using them
The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from...
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7432097 |
Phytases, nucleic acids encoding them and methods of making and using them
In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared...
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7429474 |
2-O sulfatase compositions and methods of analyzing therewith
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7416876 |
N-carbobenzyloxy (N-CBZ)-deprotecting enzyme
This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications,...
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7416875 |
Cytotoxic ribonuclease variants
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the...
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7416865 |
Process for the preparation of dihydroxy esters and derivatives thereof
A process is provided for the preparation of a compound of formula (1)
wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The...
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7416856 |
High sensitivity assay for detection of nucleoside diphosphate production
The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as...
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7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
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7405070 |
Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme
Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior...
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7402414 |
Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol
A process for preparing the compound of formula II by reacting the compound of formula I with an enzyme that can hydrolyze the ester bond:
where * indicates a chiral center, R 1 and R 2 ...
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7402310 |
Deoxyribonuclease, gene encoding same and use thereof
This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic...
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7396824 |
2-O sulfatase nucleic acid compositions
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7396669 |
Mammalian endonucleases and methods of use
Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular...
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7396667 |
Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product
A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a...
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7390643 |
Geranyl diphosphate synthase molecules, and nucleic acid molecules encoding same
In one aspect, the present invention provides isolated nucleic acid molecules that each encode a geranyl diphosphate synthase protein, wherein each isolated nucleic acid molecule hybridizes to a...
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7384761 |
Methods of identifying an agent capable of interfering with Rad9 dephosphorylation
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host...
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7378254 |
Compositions and assays utilizing ADP or phosphate for detecting protein modulators
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods...
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7375091 |
HER-2/neu fusion proteins
The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and...
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7368270 |
Human phospholipases
The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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7358074 |
Human phosphatase RET31, and variants thereof
The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant...
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