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7592165 |
Process for the enzymatic preparation of an amide from a nitrile
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are...
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7590494 |
Drug design based on the structure of LTA4 hydrolase
The present invention relates to an isolated leukotriene A 4 (LTA 4 ) hydrolase, which LTA 4 hydrolase is present in its naturally occurring three dimensional form. It is the first...
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7566556 |
Enhancing enzyme thermostability by mixing with sorghum liquor waste
A composition containing a thermolabile protein admixed with a liquor waste. Also disclosed is a method of preparing such a composition which contains a protein with enhanced thermostability.
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7556956 |
Enzymes for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for...
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7553651 |
Crystal structure of SNAP-25 in complex with botulinum neurotoxin and uses thereof
The present invention provides a crystallized form of the E223Q Y365F mutant of the light chain of botulinum neurotoxin serotype A (BoNT/A) protein as well as the atomic structure of this mutant...
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7527959 |
EGVII endoglucanase and nucleic acids encoding the same
The present invention provides an endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7527936 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides,...
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7514067 |
Methods for tumor diagnosis and therapy
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
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7507568 |
Three dimensional coordinates of HPTPbeta
The crystal structures of catalytic domain of HPTPbeta, both ligand-bound and ligan-free are described. These structures are useful in computer aided drug design for identifying compounds that bind...
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7498157 |
Three-dimensional structure of dipeptidyl peptidase IV
A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the...
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7485294 |
Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
Forms of colonic delivery suited to be used orally and designed for colonic delivery of active ingredients selected from the group comprising enzymes capable of inactivating macrolide antibiotics...
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7482146 |
Phenylethanolamine-N-methyltransferase sequence variants
Isolated PNMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PNMT allozymes. Methods for determining if a...
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7455998 |
Methods for forming structurally defined organic molecules
Methods of forming organic molecules comprising contacting a hydrolase enzyme with an organic reactant are provided. Methods for forming an organosilicon molecule comprising contacting a hydrolase...
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7445918 |
Pullulanase variants and methods for preparing such variants with predetermined properties
The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity,...
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7442534 |
Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various...
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7442372 |
Delivery of therapeutic compounds to the brain and other tissues
The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human...
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7439034 |
Alginases, systems containing alginases and methods of cloning, purifying and/or utilizing alginases
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
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7435572 |
Methods and compositions for DNA manipulation
Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition....
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7435420 |
Dipeptidyl peptidase IV inhibitors for the treatment of anxiety
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression,...
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7429472 |
Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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7427498 |
Composition, methods and reagents for the synthesis of a soluble form of human PHEX
This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to...
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7425436 |
Covalent tethering of functional groups to proteins and substrates therefor
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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7422888 |
Thermotolerant ribonuclease H
Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
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7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
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7407779 |
Modification of solid 3-sn-phosphoglycerides
Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A 2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine,...
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7405070 |
Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme
Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior...
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7402406 |
Methods of evaluating phosphatase inhibitors
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using...
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7396667 |
Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product
A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a...
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7396533 |
Polypeptides and nucleic acids encoding same
DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid...
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7371366 |
GlcNAc phosphotransferase of the lysosomal targeting pathway
The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
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7368272 |
Expression of proteolytic enzymes in koji mold in the presence of carbon sources
The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the...
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7364848 |
Integrated microarray analysis
The present invention relates to methods for identifying analyte nucleic acids present in a sample comprising nucleic acid molecules, said method comprising the steps of: (a) providing a porous...
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7361495 |
Polypeptide from a cellulolytic fungus having cellulolytic enhancing activity
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7361494 |
Tetrahydropyrimidine dioxygenase gene, polypeptides encoded by said gene and method for producing the same
The present invention relates to enzymes having tetrahydropyrimidine dioxygenase activity, to the genes coding therefor, to the homologous and heterologous expression of these genes, to processes...
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7361335 |
Methods for using an elastase
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
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7354756 |
Intein-mediated cyclization of peptides
Methods of producing cyclic peptides and splicing intermediates of peptides in a looped conformation are disclosed. The methods utilize the trans-splicing ability of split inteins to catalyze...
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7351568 |
EGVI endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host...
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7335722 |
Peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
The invention discloses five peptides which can be used as angiotensin converting enzyme inhibitor. The subject invention also discloses a process for the preparation of the products having...
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7329527 |
Serine proteases from gram-positive microorganisms
The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the ...
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7329523 |
Phosphoserine phosphatase of coryneform bacteria and variants thereof
The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that...
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7320886 |
BGL4 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host...
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7320877 |
Dihydroorotase extracted from plants
The present invention relates to a DNA encoding a polypeptide with dihydroorotase (EC 3.5.2.3) activity. Also, the invention relates to the use of this nucleic acid for the generation of an assay...
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7312056 |
Enhancement of enzyme activity through purification and immobilization
An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and...
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7306936 |
Alpha-amylase variants
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the...
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7300775 |
Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids,...
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7297527 |
Highly productive α-amylases
The invention relates to mutant α-amylases that may be produced at high yield from recombinant microorganisms.
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7294761 |
Method for efficiently producing transgenic plant using auxin precursor
A method for producing a transgenic plant, which comprises: (A) introducing a vector into a plant cell, wherein the vector is a vector for gene introduction into a plant and comprises: a desired...
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7294705 |
Anti-PRO3580 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7294495 |
PR03580 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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