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7619059 |
Bimolecular optical probes
Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically...
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7618800 |
Glycerol kinase, which has high resistance against preservative
The disclosure relates to (i) a gene isolated from Cellulomonas sp.JCM2471, the gene encoding a new glycerol kinase and (ii) a method for preparing the glycerol kinase by gene recombination...
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7608434 |
Mutated Tn5 transposase proteins and the use thereof
Transposase proteins that are modified relative to and have higher transposase activities than the wild-type Tn5 transposase are disclosed. A transposase protein of the present invention differs...
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7598288 |
Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
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7595180 |
RNA-dependent RNA polymerase functioning preferably on a RNA matrix and promoter-dependent transcription process with said RNA-dependent RNA polymerase
RNA may be transcribed using a nucleotide reagent as the promoter. The reagent may enable RNA to be transcribed without sequence specification and without protein cofactors, by means of an RNA...
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7595179 |
Recombinant reverse transcriptases
The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and...
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7593820 |
Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof
The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a...
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7592161 |
Methods for analyzing the insertion capabilities of modified group II introns
The present invention provides a system and methods for analyzing the function of nucleotide integrases and modified group II introns. The system comprises a donor plasmid comprising a wild-type or...
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7588939 |
Nucleotide sequences encoding RAMOSA3 and sister of RAMOSA3 and methods of use for same
The invention relates to the isolation and characterization of a maize gene, RAMOSA3 (RA3), responsible for meristem development and inflorescence development including branching. The gene, gene...
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7585653 |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal...
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7584087 |
Structure of protein kinase C theta
A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
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7582461 |
Kinase and phosphatase assays
Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage...
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7569536 |
Method for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation...
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7569377 |
Method of heat-stabilizing α-glucan phosphorylase(GP)
An α-glucan phosphorylase having improved thermostability, which obtained by modifying natural α-glucan phosphorylase, and a method for producing this α-glucan phosphorylase having improved...
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7566559 |
Human cyclin-dependent kinase (hPNQALRE)
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for...
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7566550 |
Screening method for developing drugs against pathogenic microbes having two-component system
The present invention relates to a package of screening methods for developing drugs against pathogenic microbes having two-component system of DevR-DevS and/or DevR-Rv2027c and its homologues,...
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7566546 |
Modulators of angiogenesis and tumorigenesis
The present invention relates to regulation of angiogenesis and tumorigenesis. The invention further relates to methods for identifying and using agents, including small organic molecules,...
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7563781 |
Triazolopyrimidine derivatives
The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
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7563610 |
Crystalline composition of farsenyl pyrophosphate synthase (IspA)
Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.
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7560260 |
Compositions with polymerase activity
The invention provides novel compositions with polymerase activity and methods of using the compositions.
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7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
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7556958 |
Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof
A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus , and...
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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7541170 |
Nucleic acid modifying enzymes
This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a...
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7537920 |
Method for the production of polyunsaturated fatty acids
The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having...
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7534593 |
Crystals of glucokinase and methods of growing them
Crystalline forms of mammalian Glucokinase, ideally human liver isozyme source, of sufficient size and quality to obtain structural data by X-ray crystallography are presented. Methods of growing...
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7534589 |
Polymer grafting by polysaccharide synthases
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate synthase from Pasteurella multocida.
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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7521230 |
Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof
The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided....
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7521175 |
Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic...
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7514210 |
Compartmentalised self replication method for in vitro evolution of molecular libraries
We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a...
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7510858 |
IRAK 1c splice variant and its use
IRAK 1c [Interleukin-1 Receptor-Associated Kinase 1c] splice variants and their preparation and use are described. The splice variants may be used in drug screening assays and methods for...
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7507567 |
RNA polymerase mutants with increased thermostability
The present application relates to mutated RNA polymerases from bacteriophages that have increased stability, for example under high temperature conditions. Preferred mutated RNA polymerases...
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7507555 |
Probe for detecting and quantifying lipid second messenger and method of detecting and quantifying lipid second messenger using the same
The present invention provides probes for detection and quantification of a lipid second messenger, which comprises: a polypeptide specifically bound to the lipid second messenger; two chromophores...
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7504242 |
Process for the fermentative production of amino acids using coryneform bacteria in which OpcA gene expression is amplified
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
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7504228 |
Integrin linked kinase modulation of monocyte activation
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the...
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7494797 |
Recombinant terminal deoxynucleotidyl transferase with improved functionality
Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus, characterized in that the derivative in comparison to the native TdT is N-terminally truncated by up to 161 amino...
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7491523 |
Voltage-dependent calcium channel beta subunit functional core
The present invention relates to crystallized forms of a voltage dependent calcium channel β subunit functional core, methods of producing and methods of utilizing the same.
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7485712 |
Protein kinase (NPK-110)
The present invention relates to a DNA sequence encoding a novel neuronal protein kinase (NPK) which phosphorylates tau proteins as well as other microtubule associated proteins (MAPs) in positions...
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7482145 |
Deglycosylated enzymes for conjugates
By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the...
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7479385 |
Sugar kinases with expanded substrate specificity and their use
One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred...
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7476731 |
Variants of the alpha 1 subunit of human AMPK
Variants of the α subunit of AMPK, nucleic acids encoding such variants, and methods for their use are provided.
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7473773 |
Determination of hepatitis C virus genotype
The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for...
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7462475 |
Use of whole blood in PCR reactions
A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase.
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7459297 |
Active truncated form of the RNA polymerase of flavivirus
The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase...
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7459296 |
Hepatitis C virus NS3 helicase subdomain I
This invention provides fragments of HCV NS3 helicase, and crystalline compositions thereof, based on subdomains of HCV helicase protein. The protein fragments are stable, soluble, and structurally...
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7452705 |
N4 virion single-stranded DNA dependent RNA polymerase
A histidine-tagged, deletion mutant of bacteriophage N4-coded, virion RNA polymerase (mini-vRNAP) which is active has been developed. The his-tagged mini-vRNAP has been cloned under the control of...
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7452686 |
JNK inhibitors for the treatment of neurological disorders
The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This...
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7444273 |
Crystallization of aurora/LPL1P-related kinase
Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
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7442766 |
Pfu replication accessory factors and methods of use
This invention provides isolated polynucleotides that encode replication accessory factors. The invention also provides novel DNA replication accessory factors, which have been isolated and...
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