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7611875 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid...
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7611873 |
Method for producing L-methionine by fermentation
L-Methionine is produced by culturing a microorganism which is deficient in repressor of L-methionine biosynthesis system and/or enhanced intracellular homoserine transsuccinylase activity is...
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7608754 |
Double fructan beets
The present invention relates to fructan producing plants particularly to methods for the production of fructans having a low degree of polymerization. The invention is also directed to non-fructan...
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7608703 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7608702 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7608443 |
Lysophosphatidic acid acetyltransferases
An isolated nucleic acid fragment encoding an LPAAT isozyme is disclosed. Construction of a chimeric gene encoding all or a portion of the LPAAT isozyme, in sense or antisense orientation, wherein...
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7608442 |
β1,3-galactosyltransferase polypeptides from the LOS locus of C. jejuni
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a...
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7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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7608432 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7604976 |
Sequence-determined DNA fragments encoding glutamine amidotransferase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7604973 |
DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this...
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7604972 |
Nicotianamine synthase
A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing...
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7604971 |
Sequence-determined DNA fragments encoding UBIE/COQ5 methyltransferase family proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7604970 |
Variants of the PapM polypeptide of bacteria of the Streptomyces genus
The present invention relates to novel variants of the PapM polypeptide of bacteria of the Streptomyces genus which possess a substrate selectivity and/or an improved effectiveness compared to...
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7604968 |
Microorganisms for the recombinant production of resveratrol and other flavonoids
The invention provides methods and materials related to producing flavonoids as well as other organic compounds. For example, the invention provides isolated nucleic acids, polypeptides, host...
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7601889 |
Elongase gene and production of Δ9-polyunsaturated fatty acids
This invention relates to a new elongase gene having the sequence SEQ ID NO: 1 or its derivatives, to a gene construct comprising this sequence or its derivatives and to its use. The inventive...
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7601519 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7598068 |
Chondroitin polymerase and DNA encoding the same
A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and...
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7598065 |
S-adenosylmethionine-6-N-lysine-methyltransferase from Neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell
Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neurospora crassa , a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a...
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7595156 |
Genes for synthesis of FR-008 polyketides
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes...
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7588922 |
Nucleic acid molecules encoding enzymes having fructosyltransferase activity, and their use
Nucleic acid molecules are described which encode polypeptides having the enzymatic activity of a fructosyltransferase. Also, vectors, host cells and transgenic plants are described which contain...
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7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
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7582457 |
Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis
Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for...
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7579175 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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7575900 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7575895 |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
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7575885 |
Tyrosylprotein sulfotransferases and methods of use thereof
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been...
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7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
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7572614 |
Crystal structure of soluble glutaminyl cyclase
A crystalline structure of glutaminyl cyclase (QC). is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of...
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7572607 |
Polypeptides and biosynthetic pathways for the production of monatin and its precursors
Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided....
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7569376 |
Fucosyltransferase fusion protein
This invention provides recombinant glycosyltransferase fusion proteins having a desired level of expression and enzymatic activity (for example, acceptor substrate specificity or catalytic...
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7566557 |
Gene variants coding for proteins from the metabolic pathway of fine chemicals
The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7563589 |
Reconstituted histone methyltransferase complex and methods of identifying modulators thereof
The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3...
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7560252 |
Borrelidin-producing polyketide synthase and its use
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis...
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7557261 |
Modification of fructan biosynthesis
The present invention relates to the modification of fructan biosynthesis in plants and, more particularly, to enzymes involved in the fructan biosynthetic pathway and nucleic acids encoding such...
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7556947 |
Method for producing β-hydroxy amino acid and enzyme used therefor
A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene...
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7553650 |
Polynucleotide encoding a mutant transglutaminase
The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense ...
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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7544466 |
Ghrelin o-acyltransferase (GOAT) biochemical assay
Ghrelin is acylated by ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a...
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7541193 |
Caged sensors, regulators and compounds and uses thereof
A number of caged (e.g., photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense...
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7534934 |
Precise breeding
The present invention relates to a method for identifying and isolating native plant nucleic acid sequences that may function as T-DNAs or T-DNA border-like sequences, effecting the transfer of one...
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7534589 |
Polymer grafting by polysaccharide synthases
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate synthase from Pasteurella multocida.
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7531339 |
Glyphosate-N-acetyltransferase (GAT) genes
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable...
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7531338 |
Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each....
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7531337 |
Method of controlling acetylation of metabolic enzymes
A method for modulating the activity of an AMP-forming enzyme (AFE) is disclosed. The method is based upon the novel observation that the activity of these enzymes is controlled by acetylation of...
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7527963 |
Acetyl-CoA acyltransferase gene disrupted bacterium for producing polyhydroxyalkanoate and method for producing polyhydroxyalkanoate using the same
A method for producing a polyhydroxyalkanoate with improved productivity and composition is provided. Polyhydroxyalkanoate is produced by a bacterium for producing polyhydroxyalkanoate in which a...
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7527962 |
Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules,...
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7527954 |
Method for in vitro evolution of polypeptides
The invention relates to a method for the production and allocation of nucleic acids and polypeptides coded thereby. The method can be used for evolutionary selection of polypeptides in vitro. The...
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7527953 |
Genes from Propionibacterium freudenreichii encoding enzymes involved in vitamin B12 biosynthesis
Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway...
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