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6482622 |
Amylolytic enzyme variants
The inventors have discovered some striking, and not previously predicted structural similarities and differences between the structure of Novamyl and the reported structures of CGTases, and based...
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6479267 |
FY7 polymerase
A purified recombinant thermostable DNA polymerase polymerase which exhibits at least about 80% activity at salt concentations of 50 mM and greater, at least about 70% activity at salt...
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6471959 |
Human transferase
The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6472192 |
Cyclodextrin glycosyl transferases for producing &ggr -cyclodextrin
CGTases, which, when converting starch or starch-like substrates to CD, produce γ-CD to an increased extent and still exhibit at least 60% of the specific total CGTase activity of the starting...
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6472182 |
Process for producing transglutaminase by microorganism
The present invention provides a process for producing a transglutaminase, which comprises culturing microorganisms of any of the genus Micrococcus, Clostridium, Torulopsis, Rhizopus and Monascus...
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6465179 |
DNA encoding an arthropod chitin synthase
The present invention relates to nucleic acids comprising a nucleotide sequence encoding at least a portion of an enzyme which catalyzes the synthesis of chitin in arthropods, inhibitors directed...
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6465220 |
Glycosylation using GalNac-T4 transferase
The use of human polypeptide N-acetylgalactosaminytransferase T-4 (GalNAc-T4) to glycosylate substrates is disclosed. The action of GalNAc-T4 can complement the activities of GalNAc-T1, -T2 and...
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6465229 |
Plant caffeoyl-coa o-methyltransferase
This invention relates to an isolated nucleic acid fragment encoding a caffeoyl-CoA O-methyltransferase. The invention also relates to the construction of a chimeric gene encoding all or a portion...
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6462177 |
Mammalian blood loss-induced gene, kd312
Disclosed are nucleic acids encoding novel proteins, designated kd312. Also disclosed are amino acid sequences for kd312 polypeptides, methods for preparing kd312 polypeptides, and other related...
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6458574 |
Treatment of a α-galactosidase a deficiency
The invention provides highly purified α-Gal A, and various methods for purifying it; α-Gal A preparations with altered charge and methods for making those preparations; α-Gal A preparations...
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6458572 |
Phosphatidylglycerophosphate synthase from Staphylococcus aureus
The invention provides Phosphatidylglycerophosphate Synthase polypeptides from Staphylococcus aureus (“pgsA polypeptides”). Also provided are methods for utilizing pgsA polypeptides to screen...
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6455290 |
Tankyrase homolog protein (THP), nucleic acids, and methods related to the same
The present invention provides a human polypeptide homolog of human tankyrase protein (THP) and polynucleotides which identify and encode THP. In addition, the invention provides expression...
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6455289 |
Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same
Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence...
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6451537 |
Gene of rice dihydrodipicolinate synthase and DNA relating to the same
In accordance with this invention, there is provided a DNA sequence which can encode an enzyme protein functioning as the rice dihydrodipicolinate synthase (DHDPS). One example of the DNA sequence...
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6451571 |
Thymidine kinase mutants
The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino...
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6448037 |
PgsA
The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6448476 |
Plants and plant cells transformation to express an AMPA-N-acetyltransferase
The invention relates in general to plants, plant cells, methods of making, and methods of using plants and plant cells transformed to contain a DNA sequence encoding an AMPA-N-acetyltransferase,...
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6448056 |
Microbial xyloglucan endotransglycosylase (XET)
It has been found by a screening assay that XET activity is produced by an overwhelming array of phylogenetically dispersed microorganisms. Accordingly, the present invention relates to a...
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6444454 |
Method for increasing the gene expression of saccharose synthase
The invention relates to a method for increasing the gene expression of saccharose synthase. To this end the invention provides for the expression of the saccharose synthase gene to be placed under...
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6436657 |
Polynucleotides encoding aminomethyltransferases
This invention relates to an isolated nucleic acid fragment encoding a tetrahydrofolate metabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion...
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6436683 |
Human nucleic acid methylases
The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists,...
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6432708 |
Human choline acetyltransferase
Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods...
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6432913 |
Polypeptide of protein p140 and DNAs encoding it
The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the...
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6428971 |
Teichoic acid enzymes and assays
This invention discloses a novel substrate and assay for the TAP enzyme. In addition novel DNA, proteins and peptides from genes and proteins associated with bacterial teichoic acid biosynthetic...
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6428993 |
Transglutaminase from oomycetes
The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes. Unprecedented high-level expression is achievable by...
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6423519 |
Compositions and methods for inhibiting fungal growth
The present invention relates to compositions and methods for inhibiting fungal growth. In particular, the present invention relates to methods for use as anti-fungal agents of inhibitors, and...
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6416987 |
Mutants of thymidylate synthase and uses thereof
The present invention provides a mutated human TS, said mutated synthase differing from wild type TS at amino acid residue 49, amino acid residue 52, amino acid residue 108, amino acid residue 221...
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6416755 |
Human beta-alanine-pyruvate aminotransferase
The invention provides a human beta-alanine-pyruvate aminotransferase (HAPA) and polynucleotides which identify and encode HAPA. The invention also provides expression vectors, host cells,...
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6416988 |
Beta-1,3-galactosyltransferase homologs
The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are...
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6413751 |
DNA adenine methyltransferases and uses thereof
The present invention relates to the isolation and sequencing of a novel class of methyltransferase genes, including the methyltransferase gene from Rhizobium meliloti, Agrobacterium tumefaciens,...
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6410293 |
DNA fragments containing biotin biosynthetase gene and use of the same
A DNA fragment containing a gene concerned in biotin biosynthesis and derived from a microorganism belonging to the genus Sphingomonas, a plasmid containing said DNA fragment, and a...
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6403350 |
Method for rapidly obtaining enzyme crystals with desirable morphologies
The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then...
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6399321 |
Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT
The present invention relates to a method for determining the effect of a test sample on UGGT activity. The method comprises the steps of: a) exposing an acceptor substrate of UGGT such as acid...
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6399358 |
Human gene encoding human chondroitin 6-sulfotransferase
Genes and polypeptides encoded thereby of human chondroitin 6-sulfotransferase are provided. Vectors and host cells comprising these genes and transgenic animals capable of expressing them are also...
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6395525 |
Geranyl diphosphate synthase genes
An isolated recombinant protein comprising the amino acid sequence shown in SEQ ID No: 1 is disclosed. A preferred embodiment of the invention is a recombinant protein having the amino acid...
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6395524 |
Thermostable polymerases having altered fidelity and method of identifying and using same
The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at...
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6395468 |
Human phosphatidylinositol synthase
The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors...
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6395539 |
Composition and methods for bioremediation
Compositions and methods for the degradation of compounds contained in a liquid or solid waste stream are described. Genes encoding toluene-degrading enzymes are described. The enzymes have...
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6391602 |
MSP-18 protein and nucleic acid molecules and uses therefor
Novel MSP-18 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length MSP-18 proteins, the invention further provides isolated MSP-18 fusion proteins,...
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6391603 |
Genes of purine biosynthesis from Ashbya gossypii and the use thereof in microbial riboflavin synthesis
Genes of purine biosynthesis from Ashbya gossypii are used in microbial riboflavin synthesis.
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6391604 |
Thermostable enzyme having phosphatidylethanolamine N-methyltransferase activity
A thermostable phosphatidylethanolamine N-methyltransferase and a process for producing the enzyme are provided. A host cell is transformed with an expression vector containing DNA encoding a...
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6391594 |
Modified modular PKS with retained scaffold
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The...
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6379722 |
Human S-adenosyl-L-methionine methyltransferase
The invention provides a human S-adenosyl-L-methionine methyltransferase (SAM-MT) and polynucleotides which identify and encode SAM-MT. The invention also provides expression vectors, host cells,...
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6379664 |
Composition and method for the prevention and treatment of oxidative damage in ocular tissues
Thioltransferase and derivatives thereof are provided. Methods of treating or preventing cataract formation comprising administering thioltransferase or a derivative thereof are also provided....
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6376475 |
Control of immune responses by modulating activity of glycosyltransferases
The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated...
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6372466 |
C-4 specific sulfotransferase
A galactosaminoglycan 4-sulfotransferase having an activity of transferring a sulfate group from a sulfate group donor to a hydroxyl group at the C-4 position of galactosamine residue of a...
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6372457 |
Process and materials for production of glucosamine
The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified...
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6368831 |
Treatment of hyperproliferative disorders
A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a...
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6365800 |
Transgenic crops accumulating fructose polymers and methods for their production
A method for producing fructose polymers of various lengths through expression of plant-derived FTF genes in transgenic monocot plants is disclosed. Also disclosed are transgenic monocot plants...
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6361985 |
Beta-1,3-galactosyltransferase homolog, ZNSSP6
The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are...
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