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6770465 |
Engineering B-ketoacyl ACP synthase for novel substrate specificity
Methods of altering substrate specificity of beta-ketoacyl-ACP synthase, and engineered beta-ketoacyl-ACP synthases so produced are provided. DNA sequences and constructs for expression of...
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6762041 |
Method for isotope labeling of protein with enzyme
The present invention provides a method for isotopically labeling a functional group possessed by an amino acid residue of a protein. The present invention also provides a protein whose functional...
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6762046 |
Polypeptide having β-fructofuranosidase activity
A polypeptide having β-fructofuranosidase activity is obtained by the expression of a microbial gene, which polypeptide contains the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 in whole or...
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6759219 |
Methods for the biosynthesis of polyesters
Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids,...
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6753411 |
Protection-of-telomere-1 (POT-1) proteins
A protein identified in humans and Schizosaccharomyces pombe , Pot1 p , binds single-stranded telomeric DNA and both stabilizes chromosome ends and regulates telomerase activity. Compounds that...
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6750027 |
Human ubiquitin-conjugating enzyme homologs
The invention provides human ubiquitin-conjugating enzyme homologs (UCEH) and polynucleotides which identify and encode UCEH. The invention also provides expression vectors, host cells, antibodies,...
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6746837 |
Multiple drug resistance gene atrD of aspergillus nidulans
The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans . Vectors and transformed host cells comprising the multiple drug...
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6743606 |
Processive sugar transferase
The invention relates to a protein which presents identical or different catalytically active domains of glycosyltransferases and has a processive action. In particular, the same protein is...
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6740509 |
Method for the production of mucin-type glycopeptide
Methods for the production of a mucin-type glycopeptide comprising a transglycosylation using a sugar acceptor such as peptide and a sugar donor as an oligosaccharide with an...
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6737256 |
Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the...
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6734002 |
Nucleotide sequences coding for the chrS protein
The invention provides nucleotide sequences from Coryneform bacteria coding for the ChrS protein and a process for the fermentative preparation of amino acids using bacteria in which the ChrS...
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6730502 |
Fructosyltransferases
The present invention describes two novel proteins having fructosyltransferase activity. Both enzymes are derived from lactobacilli, which are food-grade micro-organisms with the Generally...
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6727083 |
Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof
DNA encoding a novel protein from Mycobacterium aurum SC-S423 capable of converting acetophenone to an optically active 1-phenylethlamine in the presence of a racemic mixture of sec-butylamine is...
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6727082 |
Assays and reagents for identifying anti-fungal agents, and uses related thereto
The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal...
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6723544 |
Biotin biosynthetic genes
The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
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6723542 |
Isolated human helicase enzymes
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6723543 |
Mutant kanamycin nucleotidyltransferases from S. aureus
It is desirable to have selective markers suitable for screening of thermophilic bacteria such as Thermus thermophilus. T. thermophilus are good research materials for investigating the...
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6723540 |
Manufacture of xylitol using recombinant microbial hosts
Novel methods for the synthesis of xylitol are described.
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6713283 |
Tyrosylprotein sulfotransferases
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding the enzymes have been...
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6713295 |
Isolated human UDP-glycosyltransferase proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present...
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6709834 |
Lipopolysaccharide α-2,3 sialytransferase of campylobacter jejuni and its uses
The structure and specificity of a recombinant α2,3-sialyltransferase from Campylobacter spp., is disclosed. Also provided are methods for using the α2,3-sialyltransferase in the production of...
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6706508 |
Ornithine carbamoyltransferase
The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant...
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6703230 |
47174, a novel human glycosyltransferase and uses thereof
The invention provides isolated nucleic acids molecules, designated 47174 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense...
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6703213 |
Substrate analogs for MurG, methods of making same and assays using same
General methods for monitoring the activity of MurG, a GlcNAc transferase involved in bacterial cell wall biosynthesis, is disclosed. More particularly, the synthesis of simplified substrate...
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6699705 |
Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a...
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6699689 |
Mass production method of antimicrobial peptide and DNA construct and expression system thereof
The present invention relates to DNA constructs that can produce antimicrobial materials efficiently from microorganisms and the preparation method thereof. The present invention also relates to...
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6699469 |
Materials and methods for treating or preventing oxalate-related disease
This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons and/or domestic or zoological...
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6699699 |
Mutated penicillin expandases
A mutated expandase enzyme having higher activity on penicillin G is provided to produce phenylacetyl-7-aminodeacetoxycephalosporanic acid (7-ADCA), which mutated expandase enzyme has one or more...
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6696279 |
Purified and isolated Mat II β subunit nucleic acids and polypeptides and therapeutic and screening methods using same
MAT II β subunit proteins and cDNAs encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated...
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6696280 |
Candida geranylgeranyl-protein transferase polypetide, compositions and methods related thereto
The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal...
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6692947 |
Human transferase proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6689593 |
Production of farnesol and geranylgeraniol
The invention provides a biological method of producing farnesol or geranylgeraniol.
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6689592 |
Process for the enzymatic production of D-pantothenic acid and/or its salts
A process for the enzymatic production of D-pantothenic acid and/or its salts or feedstuffs additives containing the latter by fermentation of microorganisms of the family Enterobacteriaceae, in...
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6682915 |
Process for the fermentative preparation of D-pantothenic acid and/or its salts
A method for the fermentative preparation of D-pantothenic acid and/or its salts or feedstuff additives containing these. Said method comprising, fermentation of Escherichia coli microorganisms...
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6682919 |
FabH
The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6682918 |
Bacterial sucrose synthase compositions and methods of use
The present invention provides isolated and purified polynucleotides that encode bacterial polypeptides that participate in the utilization of sucrose. Isolated bacterial sucrose synthase...
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6680186 |
Nucleotide sequences which encode plsC gene
The present invention relates to polynucleotides corresponding to the plsC gene and which encode 1-acyl-SN-glycerol-3-phosphate acyltransferase, methods of producing L-amino acids, and methods of...
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6673586 |
Steroid hormone receptor interacting protein kinase
The present invention features a novel p21-activated kinase that interacts with steroid hormone receptors, the steroid hormone receptor interacting p21-activated kinase (PAK SI ). In general, the...
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6670160 |
α1,2-fucosyltransferase
A bacterial α1,2-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,2-fucosyltransferase polypeptide, and active fragment thereof, which can...
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6670161 |
Compositions and methods for template-dependent enzymatic synthesis of nucleic acid
The human DNA polymerase α catalytic polypeptide has been functionally over-expressed by a recombinant baculovirus in insect cells at >1000 fold higher levels than that found in cultured normal...
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6670143 |
Method of screening compounds that inhibit lysophosphatidic acid acyltransferase
Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl...
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6664084 |
Isolated nucleic acid molecules encoding human glucuronyltransferase proteins, and related products and processes
The present invention provides amino acid sequences of human glucuronyltransferase proteins and nucleic acid sequences encoding these glucuronyltransferase proteins. The present invention provides...
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6664444 |
Transgenic plants presenting a modified inulin producing profile
A method is disclosed for producing a transgenic plant with a modified inulin producing profile comprising in its genome a combination of one or more expressible 1-SST enzyme encoding genes and one...
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6660510 |
Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom
The invention provides a DNA molecule encoding transglutaminase of Streptoverticillium ladakanum, the encoded transglutaminase and the use of the transglutaminase in industrial process.
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6660502 |
Process for processing sucrose into glucose and fructose
The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from...
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6656743 |
Human choline acetyltransferase
Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods...
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6649387 |
Enzymatic oxidative deamination process
The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin...
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6642036 |
Sinapoylglucose:malate sinapoyltransferase form malate conjugates from benozic acid glucosides
A gene has been isolated from Arabidopsis encoding sinapoylglucose:malate sinapoyltransferase (SMT). SMT is responsible for the substitution of a glucose moiety on aromatic acid glucosides with a...
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6638753 |
Nucleotide sequences which code for the cma gene
The invention relates to a genetically modified coryneform bacterium, the cma gene of which is amplified, and an isolated polynucleotide which codes for cyclopropane-mycolic acid synthase from...
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6638526 |
Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EO X PO Y wherein EO is ethylene oxide, PO is...
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