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5834262 |
Oxidation of glycolic acid to glyoxylic acid using a microbial cell transformant as catalyst
An improved process for preparing glyoxylic acid comprising using the enzyme glycolate oxidase in the form of permeabilized microbial cell transformants selected from Aspergillus nidulans,...
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5834273 |
Heat-stable and water soluble modified enzymes
A modified enzyme obtained by modifying an enzyme such as a hydrogen peroxide-generating enzyme, ascorbate oxidase, etc. with a polysaccharide, polyamino acid or synthetic polymer having a...
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5830673 |
Bioassay of selenium
The invention relates to a plasmid carrying a selenium-specifying DNA seqce of the E. coli fdhF gene upstream of the E. coli lac'Z gene which permits the incorporation of selenocystein into...
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5807735 |
Solvent-resistant microorganisms
The present invention includes microorganisms that are resistant to non-aqueous solvents. In addition, the organisms of interest are able to grow and/or carry out various organic (e.g. hydrocarbon)...
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5807926 |
Immobilized cofactor-dependent enzymes
An oxido-reducto synthesis is carried out in a liquid medium with enzymatic transformation of a substrate with an oxido-reducto cofactor dependent enzyme in the presence of a cofactor for the...
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5804047 |
Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme
An enzyme sensor system capable of quantitatively determining a particular component contained in a biological sample in a rapid and easy manner is disclosed. More particularly, an electrically...
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5801024 |
Oxidoreductase from filamentous fungi, DNA coding therefor and cells transformed with said DNA
Disclosed is a new gene which codes for a NADPH cytochrome P450 oxidoreductase from filamentous fungi. Also disclosed are a recombinant DNA molecule which comprises at least a part of that gene, an...
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5798234 |
Method for the directed modification of enzymes, modified enzymes and their use
Enzymes with modified substrate specificity and methods of obtaining same by the steps of a) determining the structure of two or more enzymes in the same group, b) comparing the structure of the...
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5798235 |
Gene encoding bacterial acetoacetylco a reductase
The present invention is a method for controlling biopolymer synthesis by determining the genetics and enzymology of polyhydroxybutyrate (PHB) biosynthesis at the molecular level. The purified...
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5795761 |
Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
Mutants of 2,5-diketo-D-gluconic acid reductase A an enzyme used to produce 2-keto-L-gluconic acid, a precursor of ascorbic acid (vitamin C), are prepared by site-directed mutagenesis. These...
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5792461 |
Citrus peel extract as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase inhibitor
A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises administering citrus peel extract thereto.
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5789395 |
Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit...
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5783414 |
Expression system, integration vector and cell transformed by this integration vector
The invention relates to an expression system which is usable for the extracellular production of glucose oxidase, which comprises the sequence of a promoter, the glucose oxidase secretion signal...
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5776742 |
Aldehyde dehydrogenase enzyme
An aldehyde dehydrogenase having the physico-chemical properties: molecular weight: 91,000±5,000; substrate specificity:active on aldehyde compounds; inhibition: by Cu 2 +, Zn 2 +, Ni 2 + and...
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5770410 |
Chiral synthesis with modified enzymes
A method for modifying the specificity or efficiency of an enzyme, while retaining its catalytic activity, is disclosed. The method is characterized by selecting an enzyme, the tertiary structure...
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5766925 |
Method of producing L-lysine
A coryneform bacterium having high L-lysine productivity is provided by integrating a gene coding for aspartokinase originating from coryneform bacteria with desensitized feedback inhibition by...
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5766874 |
Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol
A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is...
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5763236 |
Method for producing ketone or aldehyde using an alcohol dehydrogenase of Candida Parapsilosis
The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida...
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5759837 |
Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues Inhibition of fatty acid synthesis is selectively toxic to...
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5747301 |
D-sorbitol dehydrogenase
A D-sorbitol dehydrogenase in homogenous form, which catalyzes the oxidation of D-sorbitol to L-sorbose, has a molecular structure consisting of homologous subunits of molecular weight...
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5747078 |
Longterm antimicrobial activity obtained by sustained release of hydrogen peroxide
Methods for long-term preservation of food products using a lactoperoxidase system. Long-term preservation is achieved by controlled generation of hydrogen peroxide as a substrate for the...
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5744342 |
Protein having heat-resistant malate dehydrogenase activity
A novel protein having a heat-resistant malate dehydrogenase activity, a DNA fragment having a gene encoding said protein, a recombinant vector having said DNA fragment, a transformant transformed...
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5741687 |
Sorbitol oxidase reagent from xanthomonas
The sorbitol oxidase of the present invention catalyzes the reaction in which D-sorbitol is oxidized D-glucose and hydrogen peroxide.
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5741688 |
Alkaline glucose oxidase obtained from cladosporium oxysporum
A glucose oxidase obtained from a Cladosporium oxysporum strain, designated as CBS 163.94, characterized by a pH-optimum in he range pH 6-7, having more than 75% of maximum activity at pH 8,...
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5738878 |
Process for making intrinsic inhibitors of aldose reductase
An intrinsic aldose reductase inhibitor is isolated and purified from mammalian cells, such as rat or human kidney cells. The intrinsic aldose reductase inhibitor may be incorporated into...
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5728539 |
Enzymatic methods for measurement of minute amounts of copper
An accurate and effective measurement of copper in subject samples is rendered possible even for minute amounts of copper, by converting copper-bonded hologalactose oxidase to the apo-form by...
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5726045 |
Materials and methods for converting DNA to CO-DNA
Materials and methods for conversion of traditional DNA to CO-DNA are presented. Such materials and methods are useful to inhibit cell division and to monitor conversion of DNA to CO-DNA.
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5712139 |
Pyranose oxidase, pyranose oxidase gene, novel recombinant DNA and process for producing pyranose oxidase
The invention relates to a novel pyranose oxidase, a pyranose oxidase gene, and a recombinant DNA, as well as a process for producing the pyranose oxidase by use of a microorganism carrying said...
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5693490 |
Production of glycolate oxidase in methylotrophic yeast
Methylotrophic yeast have been transformed with a heterologous gene encoding glycolate oxidase. The transformed methylotrophic yeast are useful as a catalyst for transforming glycolate to glyoxylate.
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5686275 |
Synthesis of homochiral 2-hydroxy acids
A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R'...
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5683897 |
Enzymatic process for the production of dihydroxyacetone phosphate from glycerophosphate and its use in enzymatic aldol additions
The invention concerns a process for the production of dihydroxyacetone phosphate (DHAP) by enzymatic oxidation of glycerophosphate in the presence of glycerophosphate oxidase and an H 2 O 2 ...
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5663063 |
Method for producing polyester biopolymers
A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the...
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5656471 |
Lactate oxidase with an improved thermal stability and gene of the same
A lactate oxidase (LOD15, LOD1, LOD16) shows an enzymatic activity under a reaction represented by "L-lactate+oxygen➝pyruvic acid+hydrogen peroxide". A DNA molecule comprises nucleotide sequences...
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5639950 |
Nucleotide sequence encoding for bifunctional enzyme for proline production
The invention is directed to the production of plants containing a cDNA clone encoding a bifunctional enzyme, delta 1 -pyrroline-5-carboxylate synthetase, hereinafter P5CS, with both...
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5639631 |
Stable reagent for ferric ion complex indicator systems
The invention is a stable reagent used in assay systems that form a colored ferric ion complex, such as Prussian Blue. Such reagents are useful for the detection or measurement of an analyte from a...
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5614374 |
Glycerol dehydrogenase, process for its production and its use
Pyrroloquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following properties:...
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5602018 |
Hypoglycosylated recombinant glucose oxidases
Hypoglycosylated recombinant glucose oxidase with a molecular weight of ca. 68-80 kDa, a specific activity of ca. 200 U/mg unit of weight, a carbohydrate portion of ca. 12% which is obtainable by...
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5589349 |
Method for enzymatic analysis and reagant therefor
A method of enzymatic analysis utilizing a color-development signal amplification system associated with enzymatic cycling of NAD-NADH interconversion in the presence of dehydrogenase and its...
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5563324 |
Transgenic plants with altered polyol content
Transgenic plants have been produced which have been engineered to produce physiologically significant levels of sugar alcohols, or polyols, which is not natively produced by plants of the species....
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5560936 |
Intrinsic inhibitors of aldose reductase
An intrinsic aldose reductase inhibitor is isolated and purified from mammalian cells, such as rat or human kidney cells. The intrinsic aldose reductase inhibitor may be incorporated into...
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5545519 |
Electrolytic analytical methods
Enzyme electrodes having the enzyme enclosed within liposomes supported on, or in a membrane and immobilized therein are provided. The liposomes may be made using lipids and conveniently by...
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5545554 |
Lactobacillus bulgaricus having decreased acid production and/or improved aroma and flavor production
The present invention concerns Lactobacillus bulgaricus wherein the lactate dehydrogenase activity is lower than 50%, preferably lower than 10%, of the lactate dehydrogenase activity of...
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5541094 |
Glyoxylic acid/aminomethylphosphonic acid mixtures prepared using a microbial transformant
An improved enzymatic process for reacting glycolic acid and oxygen in an aqueous solution in the presence of aminomethylphosphonic acid wherein the improvement comprises using a microbial cell...
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5529906 |
Analytical system or kit for phosphatase
A system or kit for analysis of phosphatase comprising a reagent I containing NADP or NADPH as a main component, and a reagent II containing components for color-development signal amplification...
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5525481 |
Enzymatic Reagents for ethanol assay containing diamino compounds
An enzymatic assay assemblage for ethanol determination is provided. A diamino compound acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay...
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5523223 |
Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters
A keto ester reductase capable of being used in an NADH-dependent enzymatic reaction for converting β, γ and δ ketonic acid esters into the corresponding optically active β, γ and δ...
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RE35247 |
Biocatalytic production of phenolic resins with ramped peroxide addition
A process for preparing a phenolic resin which comprises preparing a reaction medium containing a phenol and a peroxidase enzyme and adding a solution of a peroxide to said medium, said peroxide...
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5510104 |
Method for killing or inhabiting the growth of sporulating microorganisms with haloperoxidase-containing compositions
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or...
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5491085 |
Method of recovering peroxidase from seed hulls using a freeze-thaw technique
Peroxidase can be recovered from seed hulls in an improved method using a freeze-thaw technique. First, the seed hulls are comminuted, placed into water and homogenized. Next, the homogenate is...
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5491078 |
Leach solution containing glucose, galactose, catalase, glucose oxidase, galactose oxidase, ascorbic acid and water soluble metal cyanides and halides
A leach solution comprises water, glucose and glucose oxidase. The oxidase acts upon the glucose to produce gluconic acid and hydrogen peroxide. The leach solution reacts with mineral elements and...
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