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6448052 |
Carbonyl reductase enzyme and methods for its use
An enzyme having carbonyl reduction activity of reducing a carbonyl compound asymmetrically to produce an optically active alcohol, a DNA coding the enzyme, a plasmid having the DNA, a transformant...
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6440688 |
Enzymatic cofactor cycling using soluble pyridine nucleotide transhydrogenase
The present invention pertains to an enzymatic reaction involving a pyridine nucleotide cofactor, wherein an enzyme is used that has a sequence of greater than 70% identity to SEQ ID NO: 2 and is...
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6432688 |
Amino alcohol dehydrogenase converts keto alcohol to amino alcohol and amino alcohol to keto alcohol
A purified amino alcohol dehydrogenase which reductively converts a keto alcohol into an amino alcohol and oxidatively converts an amino alcohol into a keto alcohol is disclosed. The enzyme is...
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6426204 |
Method for detecting candida infection
A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is...
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6423518 |
Design and production of mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency
Methods for producing mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency are provided. Also provided are mutant 2,5-diketo-D-gluconic acid reductase enzymes with...
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6413765 |
Genetically modified lactic acid bacteria having modified diacetyl reductase activities
Genetically modified lactic acid bacteria having a reduced or lacking or enhanced diacetyl reductase activity, acetoin reductase activity and/or butanediol dehydrogenase activity are provided. Such...
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6413750 |
(R)-specific alcohol dehydrogenases from lactobacillus with improved catalytic activity using an NAD&plus substrate
In a method for improving the NADH specificity of preferred NADPH-dependent dehydrogenases, the alkalinity of the enzyme is reduced in the coenzyme docking area by an appropriate change of the...
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6410265 |
Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina
This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina . The putative efflux gene is useful for probing an organism's efflux system to gain an...
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6409770 |
Bleaching and washing agents with enzyme bleaching system
A bleaching detergent composition comprising an enzyme having amino alcohol oxidase activity, a substrate for said enzyme, and a bleach catalyst or activator, a method of bleaching fabric stains...
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6410253 |
Cholesterol oxidase
A process for producing cholesterol oxidase from a recombinant microorganism, the microorganism itself and its recombinant plasmid are disclosed. The cholesterol oxidase has a particular amino acid...
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6403350 |
Method for rapidly obtaining enzyme crystals with desirable morphologies
The present invention provides a crystallization process wherein a starting temperature is selected such that a desirable crystal morphology (e.g., square) is obtained. A temperature shift is then...
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6399340 |
Vector derivatives of gluconobacter plasmid pF4
A DNA derived from plasmid pF4, which contains a region involved in the control of autonomous replication in a bacterial cell belonging to the genus Gluconobactor, with or without a part of the...
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6399324 |
Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from Streptomyces avermitilis
The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel...
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6399344 |
Isolated proteins having retinol dehydrogenase activity, and which associate with retinol binding receptors
Isolated membrane associated proteins which have a molecular weight of from about 30 kD to about 36 kilodaltons as determined by SDS-PAGE, are disclosed. The proteins have cis retinol dehydrogenase...
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6399339 |
Method for the enantioselective reduction of 3,5-dioxocarboxylic acids, their salts and their esters
The invention relates to a method for the enantioselective reduction of 3,5-dioxocarboxylic acid derivatives and their syntheses. According to the invention, compounds of formula (4) are reacted...
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6395502 |
Method and means for modulating PGE synthase activity
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
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6391602 |
MSP-18 protein and nucleic acid molecules and uses therefor
Novel MSP-18 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length MSP-18 proteins, the invention further provides isolated MSP-18 fusion proteins,...
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6391599 |
Sham-sensitive terminal oxidase gene from xylose-fermenting yeast
Disclosed is a SHAM-sensitive terminal oxidase (STO) gene from the xylose-fermenting yeast Pichia stipitis . Also disclosed is a mutant of Pichia stipitis in which the STO gene natively present...
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6372463 |
Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as...
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6362315 |
Process to control the molecular weight and polydispersity of substituted polyphenols and polyaromatic amines by enzymatic synthesis in organic solvents, microemulsions, and biphasic systems
A process of controlling the molecular weight and dispersity of poly(p-ethylphenol) and poly(m-cresol) synthesized enzymatically by varying the composition of the reaction medium. Polymers with low...
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6352847 |
Ammonia elimination liquid reagent
The invention provides an ammonia elimination reagent in solution, comprising a thermo-resistant isocitrate dehydrogenase with prominent stability under conditions at high alkaline pHs. For...
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6350601 |
Enzyme composition for use as a clinical diagnostic reagent
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline...
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6348339 |
Enzymes involved in degradation of branched-chain amino acids
This invention relates to an isolated nucleic acid fragment encoding a branched-chain amino acid degradation enzymes. The invention also relates to the construction of a chimeric gene encoding all...
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6346405 |
ARO1 multifunctional polypeptide of Candida albicans
The invention provides ARO1 polypeptides and DNA (RNA) encoding such ARO1 and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such...
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6340582 |
Process for preparing xylitol
A method for producing xylitol by allowing a microorganism belonging to the Gluconobacter oxydans or Acetobacter xylinum and having a D-arabitol dehydrogenase activity and a D-xylulose...
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6337199 |
Membrane-bound gluconate dehydrogenase, gene sequence encoding the same and production of 2-keto-D-gluconate using transformed recombinant E-coli
There is disclosed a novel membrane-bound GADH from Erwinia cypripedii ATCC29267, which is useful for the production of 2KDG at high yields under the condition free of intracellular metabolism....
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6326178 |
Method for synthesizing a composite of a conductive macromolecule and a protein
Disclosed herein is a method for synthesizing a composite of a conductive macromolecule and a protein component. The method utilizes, as the protein component, a protein composite consisting of...
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6309866 |
6-phosphogluconate dehydrogenase
The invention provides 6-phosphogluconate dehydrogenase polypeptides and polynucleotides encoding 6-phosphogluconate dehydrogenase polypeptides and methods for producing such polypeptides by...
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6303357 |
L-α-glycerophosphate oxidase gene, recombinant DNA, and method for producing modified L-α-glycerophosphate oxidase gene
This invention provides an L-α-glycerophosphate oxidase (GPO) having excellent properties such as stability, heat resistance and reactivity. A recombinant GPO obtained by replacing an amino acid...
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6303326 |
Insect salivary enzyme triggers systemic resistance
The present invention includes the characterization of the major salivary protein or enzyme of the corn earworm Helicoverpa zea for triggering resistance to bacterial blight and frogeye leafspot in...
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6291229 |
Gram-positive alkaliphilic microorganisms
The present invention provides novel aerobic, Gram-positive alkaliphilic bacteria which have been isolated from in and around alkaline soda lakes. These alkaliphiles have been analyzed according to...
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6284506 |
3-Hydroxy-3-methylglutaryl-CoA reductase polynucleotides in isoprenoid production
The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate (i.e., HMG-CoA...
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6277612 |
Polypeptides having galactose oxidase activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having galactose oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid...
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6268189 |
Fungal lactate dehydrogenase gene and constructs for the expression thereof
A fungal Ldh protein and a gene have been isolated from Rhizopus oryzae. Host organisms transformed with expression vectors containing this gene produce optically pure, or enhanced levels of...
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6258573 |
Method of producing L-serine by fermentation
Disclosed is a coryneform bacterium having resistance to azaserine or β-(2-thienyl)-DL-alanine and having L-serine productivity. Also, disclosed are D-3-phosphoglycerate dehydrogenase derived from...
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6258209 |
Multi-component system for modifying, degrading or bleaching lignin, lignin-containing materials or similar substances
Multi-component system for modifying, degrading or bleaching lignin, lignin-containing materials or similar substances, includes (a) if appropriate at least one oxidation catalyst; (b) at least one...
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6255093 |
Recombinant microbial 3-hydroxybutyrate dehydrogenase a process for its production and the use thereof
DNA molecule comprising a structural gene which codes for a bacterial protein with the enzymatic activity of 3-hydroxybutyrate dehydrogenase (3-HBDH), a recombinant DNA containing the DNA molecule,...
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6255092 |
Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof
The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida...
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6248576 |
Histidinol dehydrogenase
The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also...
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6242232 |
Purified Coprinus laccases and nucleic acids encoding same
The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors,...
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6242233 |
Aldehyde dehydrogenase
A new aldehyde dehydrogenase having the physico-chemical properties: molecular weight: 150,000±6,000 or 230,000±9,000; substrate specificity:active on aldehyde compounds;...
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6232060 |
Assay system for anti-stress agents
Methods and compositions are provided for screening compounds for anti-stress activity. A rat hepatoma-derived cell line is employed, which is particularly responsive to mitochondrial function...
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6225099 |
Alcohol dehydrogenase and its use for the enzymatic production of chiral hydroxy compounds
Stable microbial enzyme with alcohol dehydrogenase activity having an activity maximum at ca. 50° C., process for its isolation and its use for the enantioselective reduction/oxidation of organic...
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6218169 |
Aromatic amino acid catabolism enzymes
This invention relates to an isolated nucleic acid fragment encoding an aromatic amino acid catabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a...
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6204040 |
Gluconobacter suboxydans sorbitol dehydrogenase, genes and methods of use thereof
The invention relates to the fields of molecular biology, bacteriology and industrial fermentation. More specifically, the invention provides isolated nucleic acid molecules encoding the three...
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6204039 |
Plant isocitrate dehydrogenase homologs
This invention relates to an isolated nucleic acid fragment encoding an isocitrate dehydrogenase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6201110 |
Polypeptide with reduced respiratory allergenicity
The invention relates to modified polypeptides with reduced respiratory allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer...
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6197562 |
L-sorbose dehydrogenase and novel L-sorbosone dehydrogenase obtained from gluconobacter oxydans T-100
A novel L-sorbose dehydrogenase (SDH) and a novel L-sorbosone dehydrogenase both derived from Gluconobacter oxydans T-100, a DNA which encodes the SDH and/or SNDH, an expression vector which...
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6171837 |
Mouse and human 9-cis-retinol dehydrogenase
This invention provides an isolated nucleic acid molecule (SEQ ID NO:1) encoding a human 9-cis-retinol dehydrogenase. Also provided is a 9-cis-retinol dehydrogenase encoded by the isolated nucleic...
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6168935 |
Preparation of optically active alcohol substituted with one or more halogen atoms
An optically active alcohol substituted with one or more halogen atoms, such as optically active 4-halo-3-hydroxybutyrate esters, is efficiently synthesized by using a secondary alcohol...
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