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7622287 |
Myceliophthora thermophila laccase variants
The present invention relates to a method of designing laccase mutants with increased oxidation potential and/or changed pH optimum and/or altered mediator pathway and/or altered O 2 /OH −...
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7622283 |
Methods for synthesizing mevalonate
Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a...
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7622282 |
Biosynthesis of isopentenyl pyrophosphate
Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a...
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7615364 |
Polypeptide having activity of unsaturating W3-fatty acid, polynucleotide coding for the polypeptide and use thereof
The present invention provides a polypeptide having a wide substrate specificity and having a ω3 fatty acid desaturation activity, which makes efficiently unsaturated bond at ω3 position, and a...
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7611876 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid...
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7608702 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7608441 |
Sequence-determined DNA fragments encoding sterol desaturase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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7608421 |
Method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof in transgenic organisms
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts....
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7605245 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7601522 |
PUFA polyketide synthase systems and uses thereof
Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana , and biologically...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7592166 |
Enone reductase gene and microbial production of levodione
Disclosed is an isolated DNA comprising a nucleotide sequence coding for an enzyme having enone reductase activity wherein the enzyme is characterized by the following physico-chemical properties:...
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7592163 |
Highly active xylose reductase from Neurospora crassa
A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was...
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7588931 |
High arachidonic acid producing strains of Yarrowia lipolytica
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are...
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7588924 |
Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate...
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7588758 |
COX-2 function and wound healing
The invention relates to compositions and methods for enhancing bone healing, bone formation and wound healing. More specifically, it relates to the use of cyclooxygenase 2 (COX-2) following bone...
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7582458 |
Fermentation processes and compositions
The present invention provides improved fermentation processes, including for use in an ethanol production process. The improved fermentation processes include applying at least one fatty acid...
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7582457 |
Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis
Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for...
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7579176 |
Method for the production of polyhydroxyalkanoic acid
Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (PHA), from substrates which cannot be used as a source of carbon and/or...
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7575910 |
Method for producing L-fuculose and method for producing L-fucose
The present invention provides a method for producing L-fuculose and L-fucose which is suitable as an industrial method. L-Fuculose is synthesized from L-fucitol in the presence of a...
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7575909 |
Oxidoreductase from pichia capsulata
The invention relates to a NADH-dependent oxidoreductase obtained from yeasts, for example, of the genus Pichia , more particularly from Pichia capsulata . The oxidoreductace used in an enzymatic...
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7575906 |
Catalase decomposition of hydrogen peroxide in surfactants
A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the...
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7575892 |
Expression vector encoding a triterpene hydroxylase polypeptide
Soyasapogenol B is biosynthesized via two steps of hydroxylation reaction of its precursor β-amyrin. However, the gene of the hydroxylase concerned in this reaction has not been revealed....
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7572616 |
Alternative oxidase and uses thereof
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX)...
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7566553 |
Microorganism of Escherichia Sp, or Corynebacterium Sp, comprising foreign NADP dependent glyceraldehyde-3-phosphate dehydrogenase gene and method for producing L-lysine using the same
Provided are an Escherichia species microorganism and Corynebacterium species microorganism that are transformed with a foreign NADP dependent glyceraldehydes-3-phosphate dehydrogenase gene and...
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7563609 |
Mutant 2,5-diketo-L-gluconic acid reductases
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
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7560245 |
Luciferase and methods for measuring intracellular ATP using the same
The present invention relates to luciferase having resistance to a surfactant and a method for measuring intracellular ATP which is characterized in that the luciferase having resistance to a...
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7556949 |
Δ17 desaturase and its use in making polyunsaturated fatty acids
The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to...
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7556937 |
Method for producing ergosta-5,7-dienol and/or biosynthetic intermediate and/or secondary products thereof in transgenic organisms
The present invention relates to a method for the production of ergosta-5,7-dienol and/or its biosynthetic intermediates and/or metabolites by culturing genetically modified organisms, and to the...
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7553648 |
Cytochrome P450 monooxygenases consisting of thermophilic bacteria
The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genus Thermus sp., to nucleotide sequences encoding them, to the recombinant production...
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7550563 |
Method for the purification of a non-immunoglobulin protein comprising an immunoglobulin-like (Ig-like) domain
The present invention relates to a method for the purification of non-immunoglobulin proteins comprising one or more immunoglobulin-like (Ig-like) domain.
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7550286 |
Docosahexaenoic acid producing strains of Yarrowia lipolytica
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil...
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7550277 |
D-amino acid dehydrogenase and method of making D-amino acids
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of, e.g., a...
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7547532 |
Three-dimensional structure of prostaglandin D synthase and utilization thereof
A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D 2 . Crystal of a...
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7547524 |
Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and...
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7544494 |
Vitamin C from sorbosone
The present invention relates to a process for the production of vitamin C from L sorbosone using an aldehyde dehydrogenase which is isolated from Gluconobacter oxydans DSM 4025 (FERM BP-3812),...
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7541168 |
Recombinant cyclopentanone monooxygenase [cpmo]
Cyclopentanone 1,2-monooxygenase (CPMO) from Comamonas (previously Pseudomonas ) sp. strain NCIMB 9872 carries out the second step of a degradation pathway that allows the bacterium to use...
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7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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7531336 |
Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of...
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7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
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7531333 |
Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve...
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7531329 |
Carbonyl reductase, gene thereof and method of using the same
The present invention provides a novel polypeptide efficiently forming (R)-N-benzyl-3-pyrrolidinol, a polynucleotide coding for said polypeptide, and use of the same. The present invention relates...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7524666 |
Reductase gene and use thereof
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
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7524664 |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
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7517676 |
Human cyclooxygenase-3 enzyme and uses thereof
The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or...
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7517675 |
Oxidation of carbohydrates by means of peroxidases and nitroxy radicals
A method of oxidising carbohydrates and/or carbohydrate derivatives having primary alcohol groups comprising contacting a reaction medium containing said carbohydrates and/or carbohydrate...
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7514250 |
Coenzyme-binding glucose dehydrogenase
The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has...
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