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7153666 |
Methods and compositions for determination of glycated proteins
This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits...
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7150870 |
Anti-tumor agent
The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD...
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7148046 |
Crystal structure of cytochrome P450
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds...
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7144717 |
Oxidizing enzymes
Disclosed herein are phenol oxidizing enzymes obtainable from species of Stachybotrys which are useful in modifying the color associated with dyes and colored compounds, as well as in anti-dye...
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7141401 |
COX1-interacting proteins and use thereof
Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying...
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7135290 |
Methods and compositions for evolving hydrogenase genes
The invention provides methods and compositions for engineering microbes to generate Hydrogen. Some methods of the invention involve recoding of hydrogenase genes followed by subjecting the recoded...
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7135318 |
Modified reductase and its gene
There are disclosed a reductase having good heat stability, which resulted in decrease in reaction time and improvement of reaction efficiency. Specifically, disclosed is an enzyme having an amino...
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7135316 |
Escherichia coli having accession No. PTA 1579 and its use to produce polyhydroxybutyrate
The present invention provides a novel genetically modified Escherichia coli JM109 bearing accession number PTA 1579, containing the gene coding for poly-beta-hydroxybutyrate synthesis and a...
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7132268 |
Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve...
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7128904 |
Material containing metal ion ligand complex producing nitric oxide in contact with blood
Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g.,...
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7125697 |
Luciferase and photoprotein
The present invention provides a polynucleotide or polynucleotides encoding Oplophorus luciferase which is composed of 19 kDa and 35 kDa proteins, or the 19 kDa photoprotein, the recombinant...
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7118898 |
Rhodococcus bacterium, nitrilase gene, nitrylhydratase gene and amidase gene from Rhondococcus bacterium, and process for producing carboxylic acids by using them
The present invention relates to a novel Rhodococcus bacterium and to a process of hydrolyzing a cyano group of a nitrile compound using a novel Rhodococcus bacterium to produce the...
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7115403 |
Directed evolution of galactose oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantageously produced...
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7112432 |
Process for producing cis-3-hydroxy-L-proline
An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of...
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7108998 |
Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from ...
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7109009 |
Regulatory region of the CYP52A2A gene from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7109004 |
Process for reducing an alpha-keto ester
A process for preparing (R)-hydroxy ester (II)
from alpha-keto ester I
comprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enzyme and non-ketoreductase enzyme...
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7109008 |
L-glutamate oxidase
The present invention provides a novel L-glutamate oxidase, a gene encoding the enzyme, and a method for producing the enzyme. By use of a gene encoding the enzyme, L-glutamate oxidase can be...
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7105296 |
Genes encoding Baeyer-Villiger monooxygenases
Genes have been isolated from a variety of bacteria encoding Baeyer-Villiger monooxygenase activity. The genes and their products are useful for the conversion of ketones to the corresponding...
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7101694 |
Genes encoding proteins capable of regenerating luciferin, recombinant DNA and process for producing protein capable of regenerating luciferin
The present invention relates to: an isolated or synthesized gene, which encodes a protein comprising the amino acid sequence represented by SEQ ID NO: 2, an isolated or synthesized gene, which...
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7098010 |
Directed evolution of oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantagoeusly produced...
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7098011 |
Nucleic acid sequences encoding isoflavone synthase
This invention relates to an isolated nucleic acid sequence encoding isoflavone synthase. The invention also relates to the construction of chimeric sequences encoding all or a substantial portion...
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7091016 |
Carbonyl reductase of Kluyveromyces marxianus and its isolation and purification method
Carbonyl reductase (CR) of a yeast strain, Kluyveromyces marxianus , and its isolation and purification method thereof is provided. The reduction reaction by the reductase obtained in the present...
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7091031 |
Carotenoid hydroxylase enzymes
A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously...
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7087403 |
Biological production of tetradehydrolycopene
Mutant phytoene desaturase genes are provided encoding polypeptides having the ability to convert a phytoene desaturase substrate to tetradehydrolycopene. Both in vivo and in vitro methods are...
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7083960 |
Production of a highly active, soluble form of the cytochrome P450 reductase (CPR A) from Candida tropicalis
The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal...
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7083961 |
Crystal structures of T. foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof
The invention provides a crystalline complex containing T. foetus IMPDH in complex with inosine monophosphate (IMP), the complex specified by disclosed atomic coordinates. Also provided are...
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7083962 |
Carbonyl reductases, polynucleotides comprising DNA encoding the same, methods for producing the same, and methods for producing optically active alcohol utilizing the same
An objective of the present invention is to provide methods for efficiently producing (S)-1-(3,4-dimethoxyphenyl)-2-propanol at a high optical purity. Another objective is to provide novel...
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7081350 |
Methods for identifying ecdysteroid synthesis inhibitors using the drosophila P450 enzyme shade
The invention relates to methods and materials useful for identifying inhibitors of ecdysteroid biosynthetic enzymes, specifically the Drosophila P450 enzyme, shade. These methods and materials...
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7074604 |
Bioproduction of astaxanthin using mutant carotenoid ketolase and carotenoid hydroxylase genes
Protein engineered nucleic acid fragments encoding a CrtO ketolase and a CrtZ hydroxylase are provided with increased astaxanthin synthesis activity. Methods using the present nucleic acid...
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7067285 |
Desaturase genes and uses thereof
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e.,...
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7067296 |
Methods and means for modulating PGE synthase activity
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
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7067275 |
Bioanalytical measuring method for determining catalases and peroxidases, as well as conjugates, substrates, activators and inhibitors thereof
A bioanalytical method for determining catalases and peroxidases using europium ions.
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7063956 |
Fermentative carotenoid production
Novel proteins of microorganism E-396 (FERM BP-4283) and the DNA sequences which encode these proteins have been discovered to provide an improved biosynthetic pathway from farnesyl pyrophosphate...
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7063972 |
Cytochrome P450 monooxygenase CYP52A2A from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7063955 |
Method for production of asymmetric carotenoids
Genes have been isolated from Rhodococcus and Deinococcus which encode a specific lycopene β-cyclase capable of converting acyclic carotenoids with at least one ψ-end group to the...
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7060435 |
Genotyping cytochrome expression
There is disclosed a method of identifying subjects having a high or low drug metabolising phenotype associated with cytochrome CYP3A5 expression, which method comprises screening genomic DNA from...
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7056713 |
Urate oxidase
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are...
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7049115 |
Genes encoding denitrification enzymes
This invention relates to the isolation of nucleic acid fragments from Methylamons sp. that encode enzymes involved in denitrification. The enzymes arc useful in denitrification reactions and for...
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7049483 |
Transgenic bioluminescent plants
Transgenic plants are created having incorporated into them a luciferase enzyme gene and a corresponding luciferin substrate gene. These genes are regulated such that for a certain amount of time...
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7049113 |
Gene encoding protein capable of regenerating luciferin, recombinant DNA and process for producing protein capable of regenerating luciferin
The present invention relates to:
an isolated or synthesized gene, which encodes a protein comprising the amino acid sequence represented by SEQ ID NO: 2, an isolated or synthesized gene,...
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7049111 |
Process for producing HMG-CoA reductase inhibitor
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus , which has an activity of hydroxylating a compound represented by the formula (I-a):
...
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7049112 |
Cytochrome P450 monooxygenase CYP52A2B from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7045600 |
Modification of collagenous materials and medical treatment, diagnosis and monitoring of fibrotic conditions
The present invention relates to the gene PLOD2 which codes for telopeptide lysyl hydroxylase (TLH). This enzyme converts telopeptidyl Lys into telopeptidyl Hyl, that can subsequently be converted...
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7045324 |
Tocopherol associated protein and uses thereof
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides...
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7045612 |
Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an...
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7041479 |
Enhanced in vitro synthesis of active proteins containing disulfide bonds
Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions,...
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7041471 |
Carotene hydroxylase and method for producing xanthophyll derivatives
The present invention relates to proteins which have an enzymatic activity for converting β-carotene into zeaxanthin or canthaxanthin into astaxanthin, to nucleic acids which encode these...
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7037709 |
Nucleotide sequence which encodes a flavin monooxygenase, the corresponding protein and their uses in the spheres of diagnosis and therapy
The nucleotide and polypeptide sequences of two novel human flavin-containing monooxygenase (FMO) enzymes are presented: hFMO2 and hFMOx. Vectors and host cells for cloning and/or expression of...
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7037697 |
Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD and use of the said SOD in cosmetic, food, and pharmaceutical compositions
The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase extracted from the plant Potentilla atrosanguinea Lodd. Var. areyrophylla, said isozyme having the...
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