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5556778 |
Crystalline Inha Enzyme-NADH Complex
The crystallized complex of NADH and Inha enzyme from Mycobacterium tuberculosis is presented. Methods of designing inhibitors to the Inha enzyme and subsequent treatment with those inhibitors of...
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5554522 |
Dihydrodipicolinate reductase crystals and three dimensional structure
This invention relates to dihydrodipicolinate reductase crystals and to methods of growing said crystals. This invention is further directed to the utilization of said crystals to determine the...
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5543298 |
Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizable compounds and preparation thereof
The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I)...
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5541108 |
Gluconobacter oxydans strains
A process for producing 2-keto-L-gulonic acid which comprises converting L-sorbose and/or D-sorbitol into 2-keto-L-gulonic acid with the aid of a microorganism or its cell free extract, said...
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5540911 |
Methods of use of human manganese superoxide dismutase
This invention provides plasmids for expression of human superoxide dismutase of analogs thereof. The invention further provides a method of producing enzymatically active human MnSOD or an analog...
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5539093 |
DNA sequences encoding enzymes useful in carotenoid biosynthesis
DNA sequences isolated from Nicotiana species (e.g., Nicotiana benthamiana and Nicotiana tabacum) have SEQ ID NOS: 1, 3, 5 and 7. The DNA sequences encode polypeptides having enzymatic activity for...
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5536654 |
Process for the production and extraction of thermostable superoxide-dismutases from a photosynthetic microorganism culture
Process for the production and extraction of thermostable super-oxide-dismutases from a photosynthetic microorganism cell. The thermostable superoxide-dismutase production and extraction process...
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5529915 |
Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin
Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active...
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5529909 |
Tyrosinase-activator protein fusion enzyme
The present invention relates to a nucleic acid sequence that encodes a fusion enzyme of tyrosinase and a tyrosinase activator protein. Further, the present invention also relates to the amino acid...
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5529926 |
Cloning and expression of DNA encoding a ripening form of a polypeptide having sulfhydryl oxidase activity
The invention relates to recombinant DNA technology for the production of an enzyme having sulfhydryl oxidase ("SOX") activity. This SOX-enzyme can be used where the oxidation of free sulfhydryl...
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5529906 |
Analytical system or kit for phosphatase
A system or kit for analysis of phosphatase comprising a reagent I containing NADP or NADPH as a main component, and a reagent II containing components for color-development signal amplification...
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5525496 |
DNA sequence encoding sterol Δ14 reductase
A gene encoding Saccharomyces cerevisiae sterol Δ14 reductase of the ergosterol biosynthetic pathway is isolated and cloned by selecting strains carrying sequences on a 2μ based vector for...
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5523223 |
Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters
A keto ester reductase capable of being used in an NADH-dependent enzymatic reaction for converting β, γ and δ ketonic acid esters into the corresponding optically active β, γ and δ...
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5516674 |
Insecticide resistance associated cytochrome 450
Disclosed are microbial cells useful for degrading insecticides and chlorinated organics and for the production of a protein which degrades insecticides and chlorinated organics, which microbial...
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5514574 |
Method of producing flavine nucleotides
Flavine nucleotides, which are useful as ingredients of nutrient compositions, raw materials for various pharmaceutical products, biochemical research reagents and so on, are produced from flavine...
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5512479 |
Method of degrading volatile organochlorides and remediation thereof
A process for degrading volatile organic contaminants such as trichloroethylene. and remediating volatile organic contaminant contaminated media using trichloroethylene induced toluene...
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5510104 |
Method for killing or inhabiting the growth of sporulating microorganisms with haloperoxidase-containing compositions
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or...
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5506138 |
Recombinant vaccinia virus encoding cytochromes P-450
The present invention is related to the construction and application of vaccinia virus containing DNA sequences for encoding and efficient expression of enzymatically active cytochrome P-450...
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5503988 |
Process for producing a cholesterol-reduced substance
The present invention relates to a process for producing a cholesterol-reduced substance obtained by converting cholesterol in a substance to epicholesterol, as well as to a novel cholesterol...
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5500351 |
Biosensors for detecting metal ions capable of being reduced by reductase enzymes
A biosensor for detecting metal ions of elements such as Hg, Cr, As, Tc, Cu, Ag, Se, V, Mo and U which are capable of being reduced to metal by a reductase enzyme. The reductase enzyme is contained...
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5491085 |
Method of recovering peroxidase from seed hulls using a freeze-thaw technique
Peroxidase can be recovered from seed hulls in an improved method using a freeze-thaw technique. First, the seed hulls are comminuted, placed into water and homogenized. Next, the homogenate is...
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5491084 |
Uses of green-fluorescent protein
This invention provides a cell comprising a DNA molecule having a regulatory element from a gene, other than a gene encoding a green-fluorescent protein operatively linked to a DNA sequence...
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5487987 |
Synthesis of adipic acid from biomass-derived carbon sources
A method is provided for producing adipic acid. The method comprises the steps of culturing a cell transformant capable of converting a carbon source to catechol for a period of time sufficient to...
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5484724 |
DNA encoding GLSI
The DNA encoding glucan synthesis gene 1 (GLS1) is cloned and used in an in vitro assay to screen for compounds that modulate 1,3β-D glucan synthase activity.
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5484723 |
Flavin reductase gene from Vibrio fischeri
A flavin reductase gene is provided having the nucleotide sequence of SEQ ID NO:1, wherein the sequence is displayed in numbered triplets of capital letters, which numbers proceed sequentially from...
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5478723 |
Method and apparatus for determining the role of cytochrome P450 and related enzymes in the metabolism of drugs and other chemicals
A method and apparatus for determining the enzyme or enzymes in the human body which metabolize a particular drug. Microsomes are obtained from each of several donors. The microsome for one donor...
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5468631 |
Gene encoding enzyme having flavin reducing activity and nitroreductase activity
The present invention succeeds in isolating a gene encoding an enzyme having an FMN reducing activity and a nitroreductase activity derived from luminous bacteria Vibrio fischeri (ATCC 7744),...
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5468630 |
cDNA clone for human inducible nitric oxide synthase and process for preparing same
A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human...
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5466600 |
Use of carbon monoxide dehydrogenase for bioremediation of toxic compounds
Toxic chlorinated compounds and nitro-aromatic compounds are rendered more environmentally friendly via a bioremediation process which employs carbon monoxide dehydrogenase, a microorganism...
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5466590 |
Constitutive expression of P450soy and ferredoxin-soy in Streptomyces
The present invention provides a method of making a recombinant organism capable of oxidizing organic chemicals by constitutive production of proteins capable of performing oxidation. A recombinant...
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5466589 |
Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same
The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a...
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5460949 |
Method and composition for increasing the accumulation of squalene and specific sterols in yeast
A method of increasing the accumulation of squalene and specific sterols in yeast comprising increasing the expression level of a structural gene encoding a polypeptide having HMG-CoA reductase...
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5459063 |
Plasmodium falciparum ribonucleotide reductase DNA
This invention relates to the ribonucleotide reductase of Plasmodium falciparum (Pf RR), to the subunits of Pf RR (Pf R1 and Pf R2), and to compounds comprising peptides derived from the Pf R2...
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5457042 |
Sod polypeptide analogs
A novel analog of human superoxide dismutase which comprises the non-acetylated, non-glycosylated form of natural human superoxide dismutase having the ser-met amino acid sequence attached to the...
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5455029 |
Therapeutic compositions comprising a mixture of human CuZn superoxide dismutase analogs
An improved plasmid for the production of superoxide dismutase on an analog thereof which upon introduction into a suitable host containing the thermolabile repressor C I renders the host capable...
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5453374 |
Trigonopsis transformant producing D-amino acid oxidase
A Trigonopsis variabilis transformed with a recombinant DNA containing a D-amino acid oxidase gene capable of expressing in Trigonopsis variabilis is provided. A process for transforming...
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5451402 |
Method for killing yeast and sporular microorganisms with haloperoxidase-containing compositions
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or...
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5451515 |
Production and recovery of tyrosinase from melanin-synthesizing bacteria
The present invention relates to the discovery of a new bacteria of the genus Alteromonas which has been found to attract oyster larvae by the production of compounds involved in melanin synthesis....
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5449613 |
Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent
A method for reacting an enzyme in a non-aqueous organic solvent is disclosed. The method comprises preparing a lyophilizate of a salt which activates the enzyme and an enzyme wherein the...
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5441887 |
Rapid degradation of halogenated hydrocarbons by soluble methane monooxygenase
A method is disclosed for degradation of a halogenated hydrocarbon compound such as trichloroethylene (TCE) which utilizes a soluble methane monooxygenase or a bacterium comprising the...
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5441885 |
Bacterial strains for bioremediation
The present invention provides a recombinant plasmid adapted for transformation of a host microorganism, the plasmid comprising a plasmid vector into which a polydeoxyribonucleotide segment that...
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5436004 |
Administration of cholesterol reductase to humans
Cholesterol reductase is administered to humans to convert cholesterol to coprostanol in the small intestine thus decreasing the bloodstream cholesterol level.
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5436159 |
Chimeric fused monooxygenase of cytochrome P-450 and NADPH-cytochrome P-450 reductase
The present invention provides a chimeric enzyme gene which codes for a monooxygenase having both monooxygenase activity derived from cytochrome P-450 and reducing power supplying ability derived...
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5432071 |
Variant E1 protein gene for pyruvate dehydrogenase complex and variant E1 protein of pyruvate dehydrogenase complex
The present invention relates to variant E 1 protein of pyruvate dehydrogenase complex of high activity in which arginine at the 146-position is replaced by proline in the amino acid sequence of...
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5424196 |
Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
Transformation of Cephalosporin C or its derivatives and salts into 7-aminocephalosporanic acid or its derivatives by an enzymatic two stage process with enzymes immobilized on a solid matrix.
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5420008 |
Assay method and assay reagent for serum iron or unsaturated iron binding capacity
The present invention measures serum iron by liberating iron from transferrin under acid conditions, and contacting a test sample with a reaction system which utilizes at least aconitase, a...
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5420028 |
Truncated human cholesterol 7α-hydroxylase, method of production and use thereof
A catalytically active, truncated human cholesterol 7α-hydroxylase (CYP7) is provided. The truncated human CYP7 can be made recombinantly and thus recovered in relatively large amounts. Vectors...
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5420027 |
Methods and compositions for the expression of biologically active fusion proteins comprising a eukaryotic cytochrome P450 fused to a reductase in bacteria
Disclosed are methods and compositions for effecting bacterial expression of eukaryotic cytochrome P450 enzymes and fusion proteins comprising a eukaryotic P450 domain fused to a reductase enzyme...
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5418155 |
Isolated Renilla luciferase and method of use thereof
Genetic material encoding luciferase from the marine coelenterate Renilla has been isolated and characterized. This genetic material allows the production of peptides for use as labels in...
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5416012 |
Process for producing NADH oxidase
A process for producing an NADH oxidase which comprises culturing alkalophilic, facultative anaerobic NADH oxidase-producing bacteria having the optimum growth pH in an alkaline region in medium...
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