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6171809 |
Method and compositions for detecting luciferase biological samples
The presence of renilla luciferase alone or both renilla luciferase and firefly luciferase is detected by adding reagent mixture(s) to a biological sample and producing glow luminescence having a...
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6162626 |
Thermostable glutamate dehydrogenase and process for producing the same
The present invention provides a process for mass producing recombinant, thermostable GLDH at a low cost. The invention also provides a process for mass producing recombinant, thermostable GLDH at...
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6159733 |
Method for photoinactivating malignant cells
The present invention provides a method for photoinactivating malignant cells in a cell sample. The method comprises incubating the cell sample with a concentration of Pc 4 effective to cause a...
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6156886 |
Cytochrome bd type quinol oxidase gene of Brevibacterium lactofermentum
Oligonucleotides are synthesized based on amino acid sequences of the N-terminus of subunit I, and the N-terminus of subunit II of cytochrome bd type quinol oxidase of Brevibacterium flavum, PCR is...
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6150130 |
DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls
Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of...
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6150513 |
Polyketide synthase enzymes and recombinant DNA constructs therefor
Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the neuroimmunophilin FK-520 polyketide. Recombinant DNA...
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6150149 |
Basidiomycete fungus-derived cytochrome P450 genes
The present invention provides: 1. A basidiomycete fungus-derived cytochrome P450 gene; 2. A vector comprising the cytochrome P450 of 1; 3. A transformant which is characterized in that...
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6146862 |
Thermostable diaphorase gene
The present invention provides a gene derived from a thermophilic Bacillus, comprising the nucleotide sequence of SEQ ID No.2 and encoding a thermostable diaphorase comprising the amino acid...
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6146863 |
Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase
The invention provides hcd polypeptides and polynucleotides encoding Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase (hcd) polypeptides and methods for producing such polypeptides by...
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6143543 |
Enzyme system comprising ferulic acid esterase from Aspergillus
An enzyme system is described that is useful for preparing food and feed. One enzyme of that system is obtainable from Aspergillus. That enzyme has the following characteristics: a MW of from 29...
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6143538 |
Fatty acyl-CoA reductase
A bacterial gene which encodes an enzyme that is an acyl-CoA reductase. The acyl-CoA reductase is able to chemically reduce acyl-CoAs to their corresponding alcohols, via aldehyde intermediates.
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6136578 |
Storage-stable liquid formulation comprising a laccase
The present invention relates to a storage-stable liquid formulation comprising a laccase comprising (i) a laccase, (ii) at least one polyalcohol, which formulation has a pH which is more alkaline...
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6132712 |
Superoxide dismutase stabilized with fragments of casein and pharmaceutical compositions incorporating same
A stabilized superoxide dismutase (SOD) peptide is described in which SOD is protected against premature proteolytic degradation by fragments of casein. The stabilized SOD is achieved by mixing the...
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6133016 |
Sphingomonas biodesulfurization catalyst
The invention relates to a novel microorganism, designated Sphingomonas sp. strain AD109, which is capable of selectively desulfurizing dibenzothiophene. The invention also includes isolated...
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6132983 |
Luciferases
Proteins are provided having luciferase activity with greater heat stability than wildtype luciferases by replacing the glutamate equivalent to that at position 354 of Photinus pyralis luciferase...
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6130077 |
Human cytochrome P450
The invention provides a human cytochrome P450 (HUCYP) and polynucleotides which identify and encode HUCYP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6127157 |
Coating material
The present invention provides a coating suitable for coating woods, and the coating is obtained by dissolving proanthocyanidine into water or a water-containing alcohol.
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6117661 |
Mutant mono-oxygenase cytochrome P450cam
A mutant of the mono-oxygenase cytochrome P450cam in which the cysteine residue at position 334 is removed.
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6117670 |
Pyrrolnitrin biosynthesis genes and uses thereof
The present invention is directed to the production of pyrrolnitrin in a host via recombinant expression of the polypeptides needed to biologically synthesize pyrrolnitrin. Genes isolated from P....
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6114509 |
Polypeptide with reduced allergenicity
The invention relates to modified polypeptides with reduced allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a...
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6107070 |
Human manganese superoxide dismutase proteins
Human manganese superoxide dismutase (hMn SOD) having catalytic activity which differs from natural hMn SOD is disclosed. The hMn SOD of the invention exhibits reduced or no product inhibition...
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6107068 |
Coenzyme A disulfide reductase, and inhibitors thereof useful as antimicrobial agents
An isolated and purified Coenzyme A disulfide reductase (CoADR) is provided. Oligonucleotides encoding the CoADR, vectors and host cells containing such oligonucleotides are also provided. In...
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6107069 |
Recombinant kynurenine-3-hydroxylase enzyme and process for its preparation
The present invention provides an isolated polynucleotide encoding for the kynurenine-3-hydrolase (Kyn-3-OHase) and methods of transiently expressing thereof.
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6103230 |
Methods for promoting wound healing and treating transplant-associated vasculopathy
The present invention provides a method of promoting the closure of a wound in a patient. This method involves transferring exogenous iNOS to the region of the wound whereby a product of iNOS is...
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6102690 |
Recombinant organisms capable of fermenting cellobiose
This invention relates to a recombinant microorganism which expresses pyruvate decarboxylase, alcohol dehydrogenase, Klebsiella phospho-β-glucosidase and Klebsiella (phosphoenolpyruvate-dependent...
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6100091 |
Modified acyl-ACP desaturase
Disclosed is a methods for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid...
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6100074 |
Mutant mono-oxygenase cytochrome P-450 .sub.cam
A mutant of the mono-oxygenase cytochrome P-450 cam in which the tyrosine residue at position 96 and/or the cysteine residue at positon 334 is replaced by the residue of any amino acid except...
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6096876 |
1-α-hydroxylase materials and methods
The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D1 α-Hydrdoxylase and polypeptides encoded thereby. It encompasses antibodies to the...
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6090603 |
Method for producing enzymes and, respectively, enzyme complexes
A method of producing enzymes in which plant seeds are subjected to a softening process and a germination process in an aqueous environment and wherein a substance is added to the aqueous...
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6090597 |
Method of producing L-lysine
A coryneform bacterium in which a DNA coding for a diaminopimelate decarboxylase and a DNA coding for a diaminopimelate dehydrogenase are enhanced is cultivated in a medium to allow L-lysine to be...
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6083708 |
Polypeptide: dendrimer complexes
Compositions are disclosed, comprising dendrimers to which a first polypeptide is controllably coupled. Such polypeptide-dendrimer compositions are effective for controllably coupling a second...
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6074859 |
Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein
According to the present invention, there can be provided a bioluminescent protein, luciferase excellent in thermostability etc. and with high catalytic efficiency.
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6066481 |
Crystallization of a protein with a sulphur salt
The present invention relates to a method for crystallization of a protein obtained from a protein-containing solution which involves (a) treating the protein-containing solution with a salt...
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6063606 |
Retinoid metabolizing protein
Amino acid sequences and corresponding nucelic acid sequence of retinoid metabolizing protein found in zebrafish and human are described.
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6054123 |
Haemophilus influenzae dimethylsulphoxide reductase enzyme
Purified and isolated nucleic acid molecules are provided which encode a dimethylsulfoxide reductase enzyme of a strain of Haemophilus or an individual subunit or a fragment or an analog of the...
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6048850 |
Method of inhibiting prostaglandin synthesis in a human host
The invention relates to the gene encoding the mammalian prostaglandin H synthase-2 and its product. More specifically, the invention relates to the diagnosis of aberrant PGHS-2 gene or gene...
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6046044 |
Cisplatin resistance proteins
Isolated nucleic acids which can confer on a cell at least a 5-fold increase in cisplatin resistance relative to a cisplatin sensitive cell are disclosed. The nucleic acids of the invention can...
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6046041 |
Method for producing marine-derived compounds and novel compounds produced therefrom
A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g.,...
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6043075 |
Endoglucanase
An endoglucanase obtainable from Dictyoglomus exhibiting optimum activity at a temperature above 85° C. is disclosed.
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6040164 |
Nucleic acids encoding nuclear Dbf2-related (Ndr) kinases
The current invention describes the identification of a novel widely-expressed human and D. melanogaster serine/threonine protein kinase (designated nuclear, Dbf2-related kinase, or Ndr; previously...
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6033889 |
Gene sequence of Aquifex pyrophilus superoxide dismutase and protein expressed in Escherichia coli
Gene sequences of superoxide dismutase of Aquifex pyrophilus which is one of hyperthermophile microorganism and protein expressed therefrom are provided, wherein the protein is used as a necessary...
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6030611 |
Therapeutic SOD compositions and uses thereof
Improved methods for production of recombinant human superoxide dismutase and analogs thereof have been developed. Such superoxide dismutase or analogs may be used to catalyze the reduction of...
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6025172 |
Isolation and sequencing of the hazel FAD2-Ngene
The invention relates to the isolation from hazel (Corylus avellana L.) of the FAD2-N gene coding for the Δ12 desaturase enzyme of the microsomal fraction and, in particular, provides the...
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6017724 |
Oxidoreductase and method for preparing 3-(p-hydroxyphenyl)-2-propenol derivatives or the like using the enzyme
The present invention relates to a novel enzyme which is derived from bacterial cells of a strain belonging to the genus Pseudomonas fluorescens and which catalyzes a reaction for oxidizing...
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6008006 |
Determination of glycated proteins
The amount of glycated proteins in a sample can be quantified by reacting the sample with first a reagent which is a combination of a protease and a peroxidase and second with a ketoamine oxidase....
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6004789 |
Process for obtaining acyloins, pyruvate decarboxylases suitable therefor and their production and DNA sequence of the PDC gene coding them
A process for obtaining a pyruvate decarboxylase by isolation from a producer organism. The pyruvate decarboxylase is capable of forming (R)-(-)-phenylacetylcarbinole (I) in ≥95% enantiomer unit...
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6001353 |
20α-alpha-hydroxy steroid dehydrogenase related material and methods
The present invention relates generally to methods of inducing contraceptive or abortive effects via modulation of levels of circulating hormones via administration of an enzyme, pharmaceutical...
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5994077 |
Flourescence-based isolation of differentially induced genes
Regulatory elements (e.g. promoters) activated by a stimulus are isolated by a FACS-based method. Preferably, a library of random fragments representative of a target (e.g. bacterial) genome are...
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5989881 |
Nucleic acid molecules encoding delta-5,7-sterol, delta-7 reductase from arabidopsis thaliana
A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of...
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5985632 |
Peptide amidase from xanthomonas
A plant peptide amidase from the flavedo of oranges is known; this can be obtained only in small quantities and is seasonal. The proposed new enzymes are microbial peptide amidases which can be...
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