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6281017 |
1-deoxy-d-xylulose-5-phosphate reductoisomerases and method of use
The present invention relates to isolated DNA sequences which code for the expression of plant 1-deoxy-D-xylulose-5-phosphate reductoisomerase protein, such as the sequence presented in SEQ ID NO:1...
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6280976 |
Nucleic acids encoding polypeptides having cellobiose dehydrogenase activity
The present invention relates to isolated nucleic acid sequences encoding polypeptides having cellobiose dehydrogenase activity. The invention also relates to nucleic acid constructs, vectors, and...
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6277611 |
Laccase mutants
The present invention relates to a method of designing laccase mutants with improved stability properties, which method is based on the hitherto unknown three-dimensional structure of Coprinus...
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6277417 |
Method of inhibiting 5α-reductase with astaxanthin
A method for inhibiting the activity of the enzyme 5α-reductase in a human subject is provided which comprises administering to the subject a composition comprising the carotenoid astaxanthin....
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6277622 |
Synthetic polynucleotides
This invention relates to synthetic polynucleotides which encode lysyl oxidase, lysyl oxidase like molecules or variants of these species. The synthetic polynucleotides of the invention permit the...
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6274359 |
25-hydroxyvitamin D3-1α-hydroxylase and DNA encoding the hydroxylase
The present invention relates to a polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such...
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6274138 |
Human mitochondrial malate dehydrogenase
The invention provides a human mitochondrial malate dehydrogenase (MT-MDH) and polynucleotides which identify and encode MT-MDH. The invention also provides expression vectors, host cells,...
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6274372 |
Rhodococcus flavin reductase complementing DszA and DszC activity
The invention provides a novel flavin reductase, which has been isolated from Rhodococcus strain sp. IGTS8 and purified to homogeneity. The flavin reductase is of use in the biocatalytic...
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6271031 |
Quinolinate metabolism enzymes
This invention relates to an isolated nucleic acid fragment encoding a quinolinate metabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6271014 |
Mammalian proteinases; related reagents and methods
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
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6268192 |
Delta 1-pyrroline-5-carboxylate reductase homolog
The invention provides a human delta 1-pyrroline-5-carboxylate reductase homolog (P5CRH) and polynucleotides which identify and encode P5CRH. The invention also provides expression vectors, host...
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6268138 |
Retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
This invention provides viral and retroviral vectors which comprises a nucleic acid molecule encoding a human cytosolic aldehyde dehydrogenase or a glutamylcysteine synthetase or combinations...
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6265177 |
Enzyme assay for mutant firefly luciferase
Enzymes and methods suitable for assaying ATP, and specific application for such assays are described and claimed. In particular, there is described a recombinant mutant luciferase having a...
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6265178 |
Assay for determining oxazolidinone antibiotics having minimum monoamine oxidase inhibitory activity
Anti-microbial oxazolidinone antibiotics are provided having formula I and formula II wherein R 1 is methyl, ethyl, cyclopropyl, or dichloromethyl; R 2 and R 3 are independently hydrogen or...
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6261780 |
Quantitative analysis of biochemical compound utilizing electrochemical reaction
A method for quantitatively analyzing a biochemical compound such as glucose or cholesterol is performed by bringing the biochemical compound into contact with double stranded DNA fragments which...
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6261814 |
Carboxylic acid reductase, and methods of using same
The present invention is directed to a novel, biologically-derived carboxylic acid reductase, also referred to herein as an aryl-aldehyde oxidoreductase, that has been isolated and purified from...
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6258209 |
Multi-component system for modifying, degrading or bleaching lignin, lignin-containing materials or similar substances
Multi-component system for modifying, degrading or bleaching lignin, lignin-containing materials or similar substances, includes (a) if appropriate at least one oxidation catalyst; (b) at least one...
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6255092 |
Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof
The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida...
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6247995 |
Bioluminescent novelty items
Systems and apparatus for generating bioluminescence, and combinations of these systems and apparatus with inanimate articles of manufacture to produce novelty items are provided. These novelty...
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6248575 |
Nucleic acids encoding polypeptides having L-amino acid oxidase activity
The present invention relates to isolated nucleic acid sequences encoding polypeptides having L-amino acid oxidase activity. The invention also relates to nucleic acid constructs, vectors, and host...
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6242232 |
Purified Coprinus laccases and nucleic acids encoding same
The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors,...
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6242234 |
Mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases
The invention relates to new mutants of formate dehydrogenase from Candida boidinii, new gene sequences encoding these and use of the new formate dehydrogenases. The wild type FDH used hitherto in...
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6242256 |
Ornithine biosynthesis enzymes
This invention relates to an isolated nucleic acid fragment encoding an ornithine biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6235485 |
Heliothis virescens-specific and Helicoverpa zea-specific monoclonal antibodies and insect identification method
Immunoassays useful for distinguishing between the insect pests Heliothis virescens and Helicoverpa zea are disclosed. These immunoassays employ either Heliothis virescens-specific monoclonal...
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6235519 |
Gene involved in thiophene biotransformation from nocardia asteroides KGB1
The present invention relates to an isolated nucleic acid molecule which encodes one or more of the enzymes which catalyze one or more steps in the desulfurization of thiophene, or a homologue or...
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6225099 |
Alcohol dehydrogenase and its use for the enzymatic production of chiral hydroxy compounds
Stable microbial enzyme with alcohol dehydrogenase activity having an activity maximum at ca. 50° C., process for its isolation and its use for the enantioselective reduction/oxidation of organic...
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6225098 |
UDP-N-acetylenolpyruvyglucosamine reductase
The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6218169 |
Aromatic amino acid catabolism enzymes
This invention relates to an isolated nucleic acid fragment encoding an aromatic amino acid catabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a...
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6218170 |
Laccase mutants
The present invention relates to laccase mutants with increased oxidation potential and/or changed pH optimum and/or altered mediator pathway and/or altered O 2 /OH - pathway.
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6218158 |
Biotransformation of fatty substrates
This invention relates to a process for enzymic oxidation of a fatty acid to produce an oxidation product in the presence of water and oxygen wherein the fatty acid, water and enzyme for the...
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6214575 |
β-carotene hydroxylase gene
The present invention provides a β-carotene hydroxylase and a DNA coding for the enzyme. The DNA of the invention codes for the following recombinant protein (a) or (b): (a) a protein...
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6214339 |
Di-enzymatic treatment of outer ear infection in dogs and cats
Otitis externa is treated in dogs and cats by administering to the outer ear of the infected animal a dosage, effective to alleviate the symptoms of the infection, of a substantially non-aqueous,...
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6214364 |
Materials and methods for pest control
The subject invention concerns methods and compositions for the selective control of pest. The method involves the administration of an enzyme that disrupts an ecdysteroid metabolic pathway wherein...
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6210895 |
Ho-1 as a diagnostic and prognostic test for dementing diseases
The invention relates to a method for predicting the onset of, diagnosing, and/or prognosticating dementing diseases. The method comprises determining the concentration of heme oxygenase-1 (HO-1)...
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6210930 |
Process for preparing doxorubicin
The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated....
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6207430 |
Nucleic acids encoding polypeptides having laccase activity
The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors,...
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6200767 |
ATP eliminator and the process for determining biological cells
The present invention provides a process for eliminating effectively ATP in a sample, using adenosine phosphate deaminase alone or in combination with at least one enzyme from the group consisting...
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6201110 |
Polypeptide with reduced respiratory allergenicity
The invention relates to modified polypeptides with reduced respiratory allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer...
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6197562 |
L-sorbose dehydrogenase and novel L-sorbosone dehydrogenase obtained from gluconobacter oxydans T-100
A novel L-sorbose dehydrogenase (SDH) and a novel L-sorbosone dehydrogenase both derived from Gluconobacter oxydans T-100, a DNA which encodes the SDH and/or SNDH, an expression vector which...
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6194185 |
Recombinant materials and methods for production of limonene hydroxylases
cDNA encoding (-)-limonene-6-hydroxylase from spearmint and (-)-limonene-3-hydroxylase from peppermint have been isolated and sequenced, and the corresponding amino acid sequences have been...
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6190881 |
Ribonucleotide diphosphate reductase, nrdF, of streptococcus pneumoniae
The invention provides nrdF polypeptides and polynucleotides encoding nrdF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6190658 |
Genetically modified manganese superoxide dismutase for treating oxidative damage
This invention discloses a genetically modified manganese superoxide dismutase nucleic acid molecule and protein. Also disclosed are recombinant molecules, recombinant cells, therapeutic...
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6187574 |
Process for producing the enzyme D-amino acid oxidase of Rhodotorula gracilis in host cells
Process for producing the enzyme D-amino acid oxydase of Rhodotorula gracilis in host cells. The process for the expression of the enzyme comprises isolating the complementary DNA corresponding to...
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6184014 |
Bacterial polyphenol oxidase from bacillus for use in oxidation of colored substances
The present invention provides polyphenol oxidases from bacteria, particularly from the genus Bacillus including, without limitation, B. licheniformis, B. natto, and B. sphaericus, In some...
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6180361 |
Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase and deacetylcephalosporin C synthetase
The present invention provides DNA compounds that encode the expandase/hydroxylase enzyme of Cephalosporium acremonium. The compounds can be used to construct recombinant DNA expression vectors for...
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6174682 |
Thioredoxin family active site molecules and uses therefor
Novel thioredoxin family active site molecules, designated MP-4 polypeptides, proteins, and nucleic acid molecules, are disclosed. In addition to isolated, full-length MP-4 proteins, the invention...
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6174712 |
Agents for inducing flower bud formation
An agent for inducing flower bud formation in plants comprising an unsaturated fatty acid having an oxo group and a hydroxy group, a hydroperoxy group, or an oxo group, a hydroxy group, and a...
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6171808 |
Mutant luciferases
Proteins are provided having luciferase activity with lower K m than wild-type luciferases by altering the amino acid residue at position 270 of the wild-type to an amino acid other than...
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6171809 |
Method and compositions for detecting luciferase biological samples
The presence of renilla luciferase alone or both renilla luciferase and firefly luciferase is detected by adding reagent mixture(s) to a biological sample and producing glow luminescence having a...
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6162626 |
Thermostable glutamate dehydrogenase and process for producing the same
The present invention provides a process for mass producing recombinant, thermostable GLDH at a low cost. The invention also provides a process for mass producing recombinant, thermostable GLDH at...
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