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7611701 |
Preparation of phytase-containing granulates for use in animal feed
A process for the preparation of an enzyme-containing granulate is disclosed where an aqueous enzyme-containing liquid is mixed with an edible carbohydrate-based solid carrier, such as starch,...
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7592167 |
Functional peptide fiber, production thereof and method for recovering peptide chains
This invention provides a functional peptide fiber which comprises a plurality of peptide structure units each containing at least one peptide chain, wherein peptide chains contained in each...
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7566556 |
Enhancing enzyme thermostability by mixing with sorghum liquor waste
A composition containing a thermolabile protein admixed with a liquor waste. Also disclosed is a method of preparing such a composition which contains a protein with enhanced thermostability.
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7524663 |
Covalently reactive transition state analogs and methods of use thereof
Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
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7507585 |
Methods and systems for indentifying and monitoring S-nitrosothiols in biological samples
The present invention describes methods and kits for determining the level of S-nitrosothiols in biological fluid samples. The method includes separating tissue or cellular matter from the...
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7507540 |
Catalytic anti-factor VIII allo-antibodies
A method is disclosed of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor...
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7482162 |
Determination of vitamin D metabolite and displacement from plasma or serum binding proteins
We disclose methods for measuring vitamin D metabolite in plasma or serum samples. The methods comprise a step of adding to the plasma or serum samples a non-competitive displacement agent...
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7482145 |
Deglycosylated enzymes for conjugates
By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the...
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7456000 |
Deactivation of linking moieties in antibody-enzyme conjugates
In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises...
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7419811 |
Use of specifically engineered enzymes to enhance the efficacy of prodrugs
The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with enhanced activity towards nucleoside analogs used in cancer chemotherapy, and delivering...
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7419600 |
Method for purifying a branched water-soluble polymer
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure
wherein Z is a moiety that can be activated for attachment to biologically active molecules...
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7416869 |
Enzyme delivery systems, application in water based products
Aqueous enzyme delivery systems as well as aqueous cosmetics and personal care products were provided which comprise at least one stabile enzyme and a polyglycerol containing at least 15 carbons....
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7413884 |
Immunological control of β-amyloid levels in vivo
Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using...
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7413739 |
Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
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7410755 |
ADP detection using an enzyme-coupled reaction
Methods and compositions are provided for determining ADP in the presence of ATP. These comprise including among the assay reagents at least one of the correcting components creatine phosphokinase...
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7393698 |
Magnetic fine particles and process for producing the same
The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of...
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7354750 |
Methods for separating molecules
The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals...
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7351586 |
Method of making stable calibrators or controls for measuring human natriuretic peptides
The present invention relates methods for making stable calibrators and controls that can be used in ligand-binding assays.
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7345149 |
Cysteine substitution variants of beta interferon
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7341720 |
Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
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7338770 |
Human procalcitonin and the preparation and use thereof
The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide...
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7335741 |
Means for use in diagnostics and/or therapy
The present invention relates to a specific reagent for the detection of the CD30 molecule, whereby this reagent is suitable in particular for the diagnosis of lymphomas.
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7335717 |
Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives
The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica,...
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7329528 |
Enzyme multimer and process of producing same
An enzyme multimer is provided which comprises a plurality of monomer units including a first monomer unit having enzymatic activity and a second monomer unit having enzymatic activity, wherein...
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7329516 |
Methods for increasing protein polyethylene glycol (PEG) conjugation
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein...
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7323167 |
Method of treatment with modified arginine deiminase
The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
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7312056 |
Enhancement of enzyme activity through purification and immobilization
An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and...
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7304016 |
Compositions for separating molecules
The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.
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7300779 |
Preparation of a granule containing protein, corn starch and sugar layered on an inert particle
Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed...
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7282567 |
Monoclonal antibody hPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding...
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7273736 |
Method for preparing an enzyme containing granule
The invention relates processes for producing enzyme containing granules having an enzyme containing core and a shell coating the core wherein the preparation of the core and application of the...
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7247462 |
Coated enzyme-containing catalyst
An enzymatic catalyst in the granular form which is non-dispersible in water comprising an inner core provided with a coating which coating comprises an enzymatic material characterised in that the...
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7238786 |
Monoclonal antibody cPAM4
This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more...
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7232888 |
Antibodies against tumor surface antigens
The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity...
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7229810 |
Polymer conjugates of proteinases
Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under...
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7220842 |
Immunoassays for buprenorphine and norbuprenorphine
Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination...
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7217796 |
Neutralizing human anti-IGFR antibody
The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing...
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7217795 |
Tumor suppressor designated TS10q23.3
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene...
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7205136 |
Catalytic antibodies
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal...
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7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
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7202346 |
Antibodies to non-shed Muc1 and Muc16, and uses thereof
The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody...
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7195925 |
Polymer having an upper critical solution temperature
The invention relates to a stimulus-responding polymer obtained by polymerizing at least a monomer represented by a general formula (1) and a monomer represented by a general formula (2), and a...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7195889 |
Process for stabilizing enzymes with phosphine or phosphite compounds
The invention relates to processes for stabilizing the activity of an enzyme, comprising mixing a phosphine or phosphite with an oxidoreductase enzyme.
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7186797 |
Polypeptide conjugates with extended circulating half-lives
The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is...
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RE39497 |
Storage of materials
A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be...
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7172907 |
Cyanine dye labelling reagents with meso-substitution
Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1):
in which groups R 3 and R 4 are attached to...
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7172905 |
Polypeptide immobilization
A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula:
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7172760 |
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to...
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7169590 |
Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization
The present invention relates to a method of efficiently producing reduced coenzyme Q 10 having excellent qualities which is useful as an ingredient in foods, functional nutritive foods, specific...
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